Literature DB >> 33578948

Human Induced Pluripotent Stem Cell-Derived Exosomes as a New Therapeutic Strategy for Various Diseases.

Aline Yen Ling Wang1.   

Abstract

Recently, an increasing number of studies have demonstrated that induced pluripotent stem cells (iPSCs) and iPSC-derived cells display therapeutic effects, mainly via the paracrine mechanism in addition to their transdifferentiation ability. Exosomes have emerged as an important paracrine factor for iPSCs to repair injured cells through the delivery of bioactive components. Animal reports of iPSC-derived exosomes on various disease models are increasing, such as in heart, limb, liver, skin, bone, eye and neurological disease and so forth. This review aims to summarize the therapeutic effects of iPSC-derived exosomes on various disease models and their properties, such as angiogenesis, cell proliferation and anti-apoptosis, with the hopes of improving their potential role in clinical applications and functional restoration.

Entities:  

Keywords:  cell-free regenerative medicine; exosome; induced pluripotent stem cells

Mesh：

Year:  2021        PMID： 33578948      PMCID： PMC7916646          DOI： 10.3390/ijms22041769

Source DB:  PubMed          Journal:  Int J Mol Sci        ISSN： 1422-0067            Impact factor:   5.923


  102 in total

1.  Human plasma membrane-derived vesicles halt proliferation and induce differentiation of THP-1 acute monocytic leukemia cells.

Authors:  Ephraim A Ansa-Addo; Sigrun Lange; Dan Stratton; Samuel Antwi-Baffour; Igor Cestari; Marcel I Ramirez; Maria V McCrossan; Jameel M Inal
Journal:  J Immunol       Date:  2010-10-04       Impact factor: 5.422

2.  Toward tailored exosomes: the exosomal tetraspanin web contributes to target cell selection.

Authors:  Sanyukta Rana; Shijing Yue; Daniela Stadel; Margot Zöller
Journal:  Int J Biochem Cell Biol       Date:  2012-06-19       Impact factor: 5.085

Review 3.  Overview of skin aging and photoaging.

Authors:  Yolanda Rosi Helfrich; Dana L Sachs; John J Voorhees
Journal:  Dermatol Nurs       Date:  2008-06

Review 4.  Induced pluripotent stem cell-derived extracellular vesicles: A novel approach for cell-free regenerative medicine.

Authors:  Behnaz Taheri; Masoud Soleimani; Sedigheh Fekri Aval; Elaheh Esmaeili; Zahra Bazi; Nosratollah Zarghami
Journal:  J Cell Physiol       Date:  2018-11-27       Impact factor: 6.384

Review 5.  Extracellular membrane vesicles as a mechanism of cell-to-cell communication: advantages and disadvantages.

Authors:  Giuseppina Turturici; Rosaria Tinnirello; Gabriella Sconzo; Fabiana Geraci
Journal:  Am J Physiol Cell Physiol       Date:  2014-01-22       Impact factor: 4.249

Review 6.  Human Pluripotent Stem Cell-Derived Extracellular Vesicles: Characteristics and Applications.

Authors:  Richard Jeske; Julie Bejoy; Mark Marzano; Yan Li
Journal:  Tissue Eng Part B Rev       Date:  2020-01-16       Impact factor: 6.389

Review 7.  Exosomes for targeted siRNA delivery across biological barriers.

Authors:  Samir El Andaloussi; Samira Lakhal; Imre Mäger; Matthew J A Wood
Journal:  Adv Drug Deliv Rev       Date:  2012-08-18       Impact factor: 15.470

8.  Large Cardiac Muscle Patches Engineered From Human Induced-Pluripotent Stem Cell-Derived Cardiac Cells Improve Recovery From Myocardial Infarction in Swine.

Authors:  Ling Gao; Zachery R Gregorich; Wuqiang Zhu; Saidulu Mattapally; Yasin Oduk; Xi Lou; Ramaswamy Kannappan; Anton V Borovjagin; Gregory P Walcott; Andrew E Pollard; Vladimir G Fast; Xinyang Hu; Steven G Lloyd; Ying Ge; Jianyi Zhang
Journal:  Circulation       Date:  2017-12-12       Impact factor: 29.690

9.  Extracellular Vesicles Released by Human Induced-Pluripotent Stem Cell-Derived Cardiomyocytes Promote Angiogenesis.

Authors:  Julie A Dougherty; Naresh Kumar; Mohammad Noor; Mark G Angelos; Mohsin Khan; Chun-An Chen; Mahmood Khan
Journal:  Front Physiol       Date:  2018-12-14       Impact factor: 4.566

Review 10.  iPSC-Derived Liver Organoids: A Journey from Drug Screening, to Disease Modeling, Arriving to Regenerative Medicine.

Authors:  Cristina Olgasi; Alessia Cucci; Antonia Follenzi
Journal:  Int J Mol Sci       Date:  2020-08-27       Impact factor: 5.923
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  3 in total

Review 1.  An insight into the iPSCs-derived two-dimensional culture and three-dimensional organoid models for neurodegenerative disorders.

Authors:  Anushka Bhargava; Ana M Sandoval Castellanos; Sonali Shah; Ke Ning
Journal:  Interface Focus       Date:  2022-08-12       Impact factor: 4.661

2.  Safety and biodistribution of exosomes derived from human induced pluripotent stem cells.

Authors:  Zhewei Gu; Zhiyu Yin; Pengbo Song; Ying Wu; Ying He; Maoshu Zhu; Zhengxin Wu; Sicheng Zhao; Hongri Huang; Huihuang Wang; Cailing Tong; Zhongquan Qi
Journal:  Front Bioeng Biotechnol       Date:  2022-08-26

Review 3.  iPSCs in NK Cell Manufacturing and NKEV Development.

Authors:  Nicholas Boyd-Gibbins; Peter Karagiannis; Do Won Hwang; Shin-Il Kim
Journal:  Front Immunol       Date:  2022-07-08       Impact factor: 8.786
  3 in total

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