Literature DB >> 33578859

Heparin-Induced Thrombocytopenia: A Review of New Concepts in Pathogenesis, Diagnosis, and Management.

Matteo Marchetti1,2, Maxime G Zermatten1, Debora Bertaggia Calderara1, Alessandro Aliotta1, Lorenzo Alberio1.   

Abstract

Knowledge on heparin-induced thrombocytopenia keeps increasing. Recent progress on diagnosis and management as well as several discoveries concerning its pathogenesis have been made. However, many aspects of heparin-induced thrombocytopenia remain partly unknown, and exact application of these new insights still need to be addressed. This article reviews the main new concepts in pathogenesis, diagnosis, and management of heparin-induced thrombocytopenia.

Entities:  

Keywords:  Bayesian diagnostic thinking; diagnosis; heparin-induced thrombocytopenia (HIT); immune PF4/heparin/antibody complexes; intravenous immunoglobulins (IVIG); management; new concepts; pathogenesis; therapeutic plasma exchange

Year:  2021        PMID： 33578859      PMCID： PMC7916628          DOI： 10.3390/jcm10040683

Source DB:  PubMed          Journal:  J Clin Med        ISSN： 2077-0383            Impact factor:   4.241


  98 in total

1.  5B9, a monoclonal antiplatelet factor 4/heparin IgG with a human Fc fragment that mimics heparin-induced thrombocytopenia antibodies.

Authors:  C Kizlik-Masson; C Vayne; S E McKenzie; A Poupon; Y Zhou; G Champier; C Pouplard; Y Gruel; J Rollin
Journal:  J Thromb Haemost       Date:  2017-09-04       Impact factor: 5.824

2.  Plasma exchange for heparin-induced thrombocytopenia in patients on extracorporeal circuits: A challenging case and a survey of the field.

Authors:  Joseph H Cho; Megan Parilla; Angela Treml; Geoffrey D Wool
Journal:  J Clin Apher       Date:  2018-11-08       Impact factor: 2.821

3.  Use of IV Immunoglobulin G in Heparin-Induced Thrombocytopenia Patients Is Not Associated With Increased Rates of Thrombosis: A Population-Based Study.

Authors:  Binod Dhakal; Lisa Rein; Aniko Szabo; Anand Padmanabhan
Journal:  Chest       Date:  2020-03-26       Impact factor: 9.410

4.  A comparative study of platelet factor 4-enhanced platelet activation assays for the diagnosis of heparin-induced thrombocytopenia.

Authors:  Julian G Rubino; Donald M Arnold; Theodore E Warkentin; James W Smith; John G Kelton; Ishac Nazy
Journal:  J Thromb Haemost       Date:  2021-02-19       Impact factor: 5.824

5.  Induction of monocyte tissue factor expression by antibodies to heparin-platelet factor 4 complexes developed in heparin-induced thrombocytopenia.

Authors:  C Pouplard; S Iochmann; B Renard; O Herault; P Colombat; J Amiral; Y Gruel
Journal:  Blood       Date:  2001-05-15       Impact factor: 22.113

6.  Endothelial cell damage in heparin-induced thrombocytopenia.

Authors:  Simon J Davidson; Paul Wadham; Louise Rogers; John F Burman
Journal:  Blood Coagul Fibrinolysis       Date:  2007-06       Impact factor: 1.276

7.  The homozygous FcgammaRIIIa-158V genotype is a risk factor for heparin-induced thrombocytopenia in patients with antibodies to heparin-platelet factor 4 complexes.

Authors:  Yves Gruel; Claire Pouplard; Dominique Lasne; Charlotte Magdelaine-Beuzelin; Chloé Charroing; Hervé Watier
Journal:  Blood       Date:  2004-06-10       Impact factor: 22.113

8.  Sera from patients with heparin-induced thrombocytopenia generate platelet-derived microparticles with procoagulant activity: an explanation for the thrombotic complications of heparin-induced thrombocytopenia.

Authors:  T E Warkentin; C P Hayward; L K Boshkov; A V Santos; J A Sheppard; A P Bode; J G Kelton
Journal:  Blood       Date:  1994-12-01       Impact factor: 22.113

Review 9.  Diagnostic accuracy of rapid immunoassays for heparin-induced thrombocytopenia. A systematic review and meta-analysis.

Authors:  Lova Sun; Phyllis A Gimotty; Suvasini Lakshmanan; Adam Cuker
Journal:  Thromb Haemost       Date:  2016-01-14       Impact factor: 5.249

10.  Combination of two complementary automated rapid assays for diagnosis of heparin-induced thrombocytopenia (HIT).

Authors:  Theodore E Warkentin; Jo-Ann I Sheppard; James W Smith; Na Li; Jane C Moore; Donald M Arnold; Ishac Nazy
Journal:  J Thromb Haemost       Date:  2020-04-27       Impact factor: 5.824
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  8 in total

1.  Delayed-onset heparin-induced thrombocytopenia complicated with saddle embolus.

Authors:  Faezeh Sadat Naji; Mahan Shafie; Mahbod Issaiy; Narjes Zarei Jalalabadi; Samaneh Parsa
Journal:  Clin Case Rep       Date:  2022-07-19

Review 2.  The clinical correlates of vaccine-induced immune thrombotic thrombocytopenia after immunisation with adenovirus vector-based SARS-CoV-2 vaccines.

Authors:  Eleanor R Gaunt; Neil A Mabbott
Journal:  Immunother Adv       Date:  2021-08-17

Review 3.  Is complement the culprit behind COVID-19 vaccine-related adverse reactions?

Authors:  Dimitrios C Mastellos; Panagiotis Skendros; John D Lambris
Journal:  J Clin Invest       Date:  2021-06-01       Impact factor: 19.456

Review 4.  Platelet factor 4 polyanion immune complexes: heparin induced thrombocytopenia and vaccine-induced immune thrombotic thrombocytopenia.

Authors:  Payel Datta; Fuming Zhang; Jonathan S Dordick; Robert J Linhardt
Journal:  Thromb J       Date:  2021-09-15

5.  A case of thrombocytopenia and multiple thromboses after vaccination with ChAdOx1 nCoV-19 against SARS-CoV-2.

Authors:  Anne Louise Tølbøll Sørensen; Magalie Rolland; Jacob Hartmann; Zitta Barrella Harboe; Casper Roed; Tomas Ø Jensen; Lilian Kolte; Daniel El Fassi; Jens Hillingsø; Aneta Radziwon-Balicka; Robert Sebastian Soyka; Klaus Hansen; Nikolai Kirkby; Jens P Goetze; Mikkel Gybel-Brask; Eva Birgitte Leinøe; Anne-Mette Hvas; Peter Kampmann; Jakob Stensballe
Journal:  Blood Adv       Date:  2021-06-22

6.  Cutaneous thrombosis associated with skin necrosis following Oxford-AstraZeneca COVID-19 vaccination.

Authors:  R Ramessur; N Saffar; B Czako; A Agarwal; K Batta
Journal:  Clin Exp Dermatol       Date:  2021-07-29       Impact factor: 4.481

7.  Autoimmune screening before adenovirus vector-based DNA vaccine in women may avoid underuse for all the subjects.

Authors:  Maria Giulia Mosconi; Francesco Caso; Giorgio Maraziti; Christine Kremer; Luisa Costa; Raffaele Scarpa; Roberto Giacomelli; Valeria Caso
Journal:  Neurol Sci       Date:  2021-12       Impact factor: 3.307

8.  Identification of Heparin-Induced Thrombocytopenia in Surgical Critically Ill Patients by Using the HIT Expert Probability Score: An Observational Pilot Study.

Authors:  Guillaume Besch; Dejan Ilic; Marc Ginet; Clément d'Audigier; Philippe Nguyen; David Ferreira; Emmanuel Samain; Guillaume Mourey; Sebastien Pili-Floury
Journal:  J Clin Med       Date:  2022-03-10       Impact factor: 4.241
  8 in total

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