Lisette Jansen1, Andrea van Steenis2, Annette A van den Berg-Huysmans3, Sica T Wiggers-de Bruine4, Monique Rijken2, Linda S de Vries2, Robert R J M Vermeiren5, Cacha M P C D Peeters-Scholte4, Sylke J Steggerda2. 1. Department of Medical Psychology, Leiden University Medical Center, Leiden, the Netherlands; Curium-LUMC Department of Child and Adolescent Psychiatry, Leiden, the Netherlands. Electronic address: l.jansen.psy@lumc.nl. 2. Department of Neonatology, Leiden University Medical Center, Leiden, the Netherlands. 3. Department of Radiology, Leiden University Medical Center, Leiden, the Netherlands. 4. Department of Neurology, Leiden University Medical Center, Leiden, the Netherlands. 5. Curium-LUMC Department of Child and Adolescent Psychiatry, Leiden, the Netherlands.
Abstract
OBJECTIVE: To assess associations between neonatal brain injury assessed by magnetic resonance imaging and cognitive, motor, and behavioral outcomes at 2 and 10 years of age, in a longitudinal cohort of children born very preterm. STUDY DESIGN: There were 112 children born at <32 weeks of gestation who participated in a longitudinal prospective study on brain injury and neurodevelopmental outcome. Using the Kidokoro score, neonatal brain injury and altered brain growth in white matter, cortical and deep gray matter, and the cerebellum were assessed. Cognitive, motor, and behavioral outcomes were assessed during follow-up visits at both 2 (corrected) and 10 years of age. RESULTS: After adjusting for perinatal factors and level of maternal education, the global brain abnormality score was associated with cognition (B = -1.306; P = .005), motor skills (B = -3.176; P < .001), and behavior (B = 0.666; P = .005) at 2 years of age, but was not associated with cognition at 10 years of age. In the subgroup of children with a moderate-severe global brain abnormality score, magnetic resonance imaging was independently associated with cognitive impairment at 10 years of age. For children with milder forms of brain injury, only birth weight and level of maternal education were associated with cognitive outcomes. CONCLUSIONS: Neonatal brain injury, assessed by a standardized scoring system, was associated with short-term neurodevelopmental outcomes, but only with motor skills and behavior in childhood. Environmental factors, such as level of maternal education, become more important for cognitive development as children grow older, especially for children with relatively mild neonatal brain injury.
OBJECTIVE: To assess associations between neonatal brain injury assessed by magnetic resonance imaging and cognitive, motor, and behavioral outcomes at 2 and 10 years of age, in a longitudinal cohort of children born very preterm. STUDY DESIGN: There were 112 children born at <32 weeks of gestation who participated in a longitudinal prospective study on brain injury and neurodevelopmental outcome. Using the Kidokoro score, neonatal brain injury and altered brain growth in white matter, cortical and deep gray matter, and the cerebellum were assessed. Cognitive, motor, and behavioral outcomes were assessed during follow-up visits at both 2 (corrected) and 10 years of age. RESULTS: After adjusting for perinatal factors and level of maternal education, the global brain abnormality score was associated with cognition (B = -1.306; P = .005), motor skills (B = -3.176; P < .001), and behavior (B = 0.666; P = .005) at 2 years of age, but was not associated with cognition at 10 years of age. In the subgroup of children with a moderate-severe global brain abnormality score, magnetic resonance imaging was independently associated with cognitive impairment at 10 years of age. For children with milder forms of brain injury, only birth weight and level of maternal education were associated with cognitive outcomes. CONCLUSIONS:Neonatal brain injury, assessed by a standardized scoring system, was associated with short-term neurodevelopmental outcomes, but only with motor skills and behavior in childhood. Environmental factors, such as level of maternal education, become more important for cognitive development as children grow older, especially for children with relatively mild neonatal brain injury.
Authors: Mountasser M Al-Mouqdad; Dima Z Jamjoom; Ayman T Abdalgader; Waleed S Ameen; Thanaa M Khalil; Yasmeen S Asfour; Maha R Al-Anazi; Suzan S Asfour Journal: Pediatr Nephrol Date: 2022-03-31 Impact factor: 3.651
Authors: V A A Beunders; J A Roelants; J Suurland; J Dudink; P Govaert; R M C Swarte; M M A Kouwenberg-Raets; I K M Reiss; K F M Joosten; M J Vermeulen Journal: AJNR Am J Neuroradiol Date: 2022-03-24 Impact factor: 3.825