Literature DB >> 3357755

Vasoactive intestinal polypeptide alters GH3/B6 pituitary cell excitability.

B Hedlund1, B Dufy, L Barker.   

Abstract

The effects of the prolactin secretagogue vasoactive intestinal peptide (VIP) on the membrane excitability of clonal prolactin-secreting (GH3/B6) cells were studied using the whole-cell configuration of the patch recording technique. Submicromolar concentrations of VIP affected membrane excitability in more than half the cells tested, increasing the frequency of spontaneous Ca2+-dependent action potentials and prolonging individual action potentials, as well as changing their rheobase. Under voltage clamp, VIP induced changes in several voltage-sensitive conductances at both instantaneous and steady-state times. Some of these changes in membrane excitability may be related to VIP's stimulatory effects on prolactin secretion.

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Year:  1988        PMID： 3357755     DOI： 10.1007/bf00582311

Source DB:  PubMed          Journal:  Pflugers Arch        ISSN： 0031-6768            Impact factor:   3.657


  16 in total

1.  Membrane effects of thyrotropin-releasing hormone and estrogen shown by intracellular recording from pituitary cells.

Authors:  B Dufy; J D Vincent; H Fleury; P Du Pasquier; D Gourdji; A Tixier-Vidal
Journal:  Science       Date:  1979-05-04       Impact factor: 47.728

2.  Afterhyperpolarization and the control of repetitive firing in spinal neurones of the cat.

Authors:  B Gustafsson
Journal:  Acta Physiol Scand Suppl       Date:  1974

3.  Vasoactive intestinal peptide (VIP) stimulates prolactin (PRL) release and cAMP production in a rat pituitary cell line (GH3/B6). Additive effects of VIP and TRH on PRL release.

Authors:  D Gourdji; D Bataille; N Vauclin; D Grouselle; G Rosselin; A Tixier-Vidal
Journal:  FEBS Lett       Date:  1979-08-01       Impact factor: 4.124

4.  Improved patch-clamp techniques for high-resolution current recording from cells and cell-free membrane patches.

Authors:  O P Hamill; A Marty; E Neher; B Sakmann; F J Sigworth
Journal:  Pflugers Arch       Date:  1981-08       Impact factor: 3.657

5.  Membrane potential changes caused by thyrotropin-releasing hormone in the clonal GH3 cell and their relationship to secretion of pituitary hormone.

Authors:  S Ozawa; N Kimura
Journal:  Proc Natl Acad Sci U S A       Date:  1979-11       Impact factor: 11.205

6.  Thyrotropin-releasing hormone mobilizes Ca2+ from endoplasmic reticulum and mitochondria of GH3 pituitary cells: characterization of cellular Ca2+ pools by a method based on digitonin permeabilization.

Authors:  S A Ronning; G A Heatley; T F Martin
Journal:  Proc Natl Acad Sci U S A       Date:  1982-10       Impact factor: 11.205

7.  Calcium-activated and voltage-dependent potassium conductances in clonal pituitary cells.

Authors:  B Dufy; J L Barker
Journal:  Life Sci       Date:  1982-05-31       Impact factor: 5.037

8.  Adenylate cyclase of rat pituitary gland: stimulation by vasoactive intestinal polypeptide (VIP).

Authors:  C Borghi; S Nicosia; A Giachetti; S I Said
Journal:  FEBS Lett       Date:  1979-12-15       Impact factor: 4.124

9.  In GH3 pituitary cells, acetylcholine and vasoactive intestinal peptide antagonistically modulate adenylate cyclase, cyclic AMP content, and prolactin secretion.

Authors:  P Onali; C Eva; M C Olianas; J P Schwartz; E Costa
Journal:  Mol Pharmacol       Date:  1983-09       Impact factor: 4.436

10.  Regulation of Ca2+-dependent cyclic AMP accumulation and Ca2+ metabolism in intact pituitary tumor cells by modulators of prolactin production.

Authors:  M A Brostrom; C O Brostrom; L A Brotman; S S Green
Journal:  Mol Pharmacol       Date:  1983-03       Impact factor: 4.436
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  4 in total

Review 1.  VIP as a cell-growth and differentiation neuromodulator role in neurodevelopment.

Authors:  J M Muller; V Lelievre; L Becq-Giraudon; A C Meunier
Journal:  Mol Neurobiol       Date:  1995 Apr-Jun       Impact factor: 5.590

2.  An inward-rectifying K+ current in clonal rat pituitary cells and its modulation by thyrotrophin-releasing hormone.

Authors:  C K Bauer; W Meyerhof; J R Schwarz
Journal:  J Physiol       Date:  1990-10       Impact factor: 5.182

3.  Different G proteins are involved in the biphasic response of clonal rat pituitary cells to thyrotropin-releasing hormone.

Authors:  C K Bauer; I Davison; I Kubasov; J R Schwarz; W T Mason
Journal:  Pflugers Arch       Date:  1994-08       Impact factor: 3.657

Review 4.  VIP: molecular biology and neurobiological function.

Authors:  I Gozes; D E Brenneman
Journal:  Mol Neurobiol       Date:  1989       Impact factor: 5.590
  4 in total

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