Literature DB >> 33576904

Cathelicidin ΔPb-CATH4 derived from Python bivittatus accelerates the healing of Staphylococcus aureus-infected wounds in mice.

Soundrarajan Nagasundarapandian1, Hye-Sun Cho1, Somasundaram Prathap1, Mingue Kang1, Munjeong Choi1, Yunjung Lee1, Hyoim Jeon1, Hyuk Song1, Jin-Hoi Kim1, Chankyu Park2.   

Abstract

The effects of ΔPb-CATH4, a cathelicidin derived from Python bivittatus, were evaluated against Staphylococcus aureus-infected wounds in mice. These effects were comparable to those of classical antibiotics. ΔPb-CATH4 was resistant to bacterial protease but not to porcine trypsin. A reduction in the level of inflammatory cytokines and an increase in the migration of immune cells was observed in vitro. Thus, ΔPb-CATH4 can promote wound healing by controlling infections including those caused by multidrug-resistant bacteria via its immunomodulatory effects.

Entities:  

Keywords:  Antimicrobial peptides; Immunomodulation; Pb-CATH4; Protease stability; Wound healing

Year:  2021        PMID： 33576904     DOI： 10.1007/s00726-021-02948-2

Source DB:  PubMed          Journal:  Amino Acids        ISSN： 0939-4451            Impact factor:   3.520


  21 in total

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Authors:  R S Howell-Jones; M J Wilson; K E Hill; A J Howard; P E Price; D W Thomas
Journal:  J Antimicrob Chemother       Date:  2005-01-13       Impact factor: 5.790

2.  In vitro and in vivo wound healing-promoting activities of human cathelicidin LL-37.

Authors:  Marta Carretero; María J Escámez; Marta García; Blanca Duarte; Almudena Holguín; Luisa Retamosa; Jose L Jorcano; Marcela Del Río; Fernando Larcher
Journal:  J Invest Dermatol       Date:  2007-09-13       Impact factor: 8.551

Review 3.  Antimicrobial peptides as potential anti-biofilm agents against multidrug-resistant bacteria.

Authors:  Pooi Yin Chung; Ramona Khanum
Journal:  J Microbiol Immunol Infect       Date:  2017-06-26       Impact factor: 4.399

4.  In vitro tests and ethnopharmacological investigations: wound healing as an example.

Authors:  P J Houghton; P J Hylands; A Y Mensah; A Hensel; A M Deters
Journal:  J Ethnopharmacol       Date:  2005-08-22       Impact factor: 4.360

5.  The quality of pediatric burn scars is improved by early administration of basic fibroblast growth factor.

Authors:  Sadanori Akita; Kozo Akino; Toshifumi Imaizumi; Katsumi Tanaka; Kuniaki Anraku; Hiroki Yano; Akiyoshi Hirano
Journal:  J Burn Care Res       Date:  2006 May-Jun       Impact factor: 1.845

6.  Chlamydia trachomatis co-opts the FGF2 signaling pathway to enhance infection.

Authors:  Jung Hwa Kim; Shaobo Jiang; Cherilyn A Elwell; Joanne N Engel
Journal:  PLoS Pathog       Date:  2011-10-06       Impact factor: 6.823

7.  The cathelicidin anti-microbial peptide LL-37 is involved in re-epithelialization of human skin wounds and is lacking in chronic ulcer epithelium.

Authors:  Johan D Heilborn; Margareta Frohm Nilsson; Gunnar Kratz; Günther Weber; Ole Sørensen; Niels Borregaard; Mona Ståhle-Bäckdahl
Journal:  J Invest Dermatol       Date:  2003-03       Impact factor: 8.551

8.  Temporins A and B stimulate migration of HaCaT keratinocytes and kill intracellular Staphylococcus aureus.

Authors:  Antonio Di Grazia; Vincenzo Luca; Li-Av T Segev-Zarko; Yechiel Shai; Maria Luisa Mangoni
Journal:  Antimicrob Agents Chemother       Date:  2014-02-10       Impact factor: 5.191

9.  Zika Virus Replication Is Substantially Inhibited by Novel Favipiravir and Interferon Alpha Combination Regimens.

Authors:  Camilly P Pires de Mello; Xun Tao; Tae Hwan Kim; Jürgen B Bulitta; Jaime L Rodriquez; Justin J Pomeroy; Ashley N Brown
Journal:  Antimicrob Agents Chemother       Date:  2017-12-21       Impact factor: 5.191

Review 10.  Immunology of Wound Healing.

Authors:  Samantha Ellis; Elaine J Lin; Danielle Tartar
Journal:  Curr Dermatol Rep       Date:  2018-09-28
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  1 in total

1.  Genomewide Analysis and Biological Characterization of Cathelicidins with Potent Antimicrobial Activity and Low Cytotoxicity from Three Bat Species.

Authors:  Munjeong Choi; Hye-Sun Cho; Byeongyong Ahn; Somasundaram Prathap; Soundrarajan Nagasundarapandian; Chankyu Park
Journal:  Antibiotics (Basel)       Date:  2022-07-22
  1 in total

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