| Literature DB >> 33576072 |
Nikoo Hossein-Khannazer1, Zeineb Zian2, Joaira Bakkach2, Ali N Kamali3,4, Ramin Hosseinzadeh5, Abubakar Umar Anka6, Reza Yazdani7, Gholamreza Azizi8.
Abstract
T helper 22 (Th22) cell populations are a newly identified subset of CD4+ T cells that primarily mediate biological effects on the epithelial barrier through interleukin (IL)-22. Although, new studies showed that both Th22 and IL-22 are closely associated with the pathogenesis of inflammatory, autoimmune and allergic disease as well as malignancies. In this review, we aim to describe the development and characteristics of Th22 cells as well as their roles in the immunopathogenesis of immune-related disorders and cancer.Entities:
Keywords: T helper 22 cell; allergic disease; autoimmune disease; inflammatory disease; malignancy
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Year: 2021 PMID： 33576072 DOI： 10.1111/sji.13030
Source DB: PubMed Journal: Scand J Immunol ISSN： 0300-9475 Impact factor: 3.487