| Literature DB >> 33575259 |
Ya Zhang1,2, Sicong Xu1,2, Gang Xu1,2, Yueying Gao1,2, Si Li1,2, Ke Zhang1,2, Zhanyu Tian1,2, Jing Guo1,2, Xia Li1,2, Juan Xu1,2, Yongsheng Li1,2.
Abstract
N6-methyladenosine (m6A) plays critical roles in human development and cancer progression. However, our knowledge regarding the dynamic expression of m6A regulators during human tissue development is still lacking. Here, we comprehensively analyzed the dynamic expression alterations of m6A regulators during seven tissue development and eight cancer types. We found that m6A regulators globally exhibited decreased expression during development. In addition, IGF2BP1/2/3 (insulinlike growth factor 2 MRNA-binding protein 1/2/3) exhibited reverse expression pattern in cancer progression, suggesting an oncofetal reprogramming in cancer. The expressions of IGF2BP1/2/3 were regulated by genome alterations, particularly copy number amplification in cancer. Clinical association analysis revealed that higher expressions of IGF2BP1/2/3 were associated with worse survival of cancer patients. Finally, we found that genes significantly correlated with IGF2BP1/2/3 were significantly enriched in cancer hallmark-related pathways. In summary, dynamic expression analysis will guide both mechanistic and therapeutic roles of m6A regulators during tissue development and cancer progression.Entities:
Keywords: cancer; gene experession; m6A regulators; survival; tissue development
Year: 2021 PMID： 33575259 PMCID： PMC7870680 DOI： 10.3389/fcell.2020.629030
Source DB: PubMed Journal: Front Cell Dev Biol ISSN： 2296-634X