Literature DB >> 33574607

Intratumoral heterogeneity in cancer progression and response to immunotherapy.

Ilio Vitale1,2, Efrat Shema3, Sherene Loi4,5, Lorenzo Galluzzi6,7,8,9,10.   

Abstract

Most (if not all) tumors emerge and progress under a strong evolutionary pressure imposed by trophic, metabolic, immunological, and therapeutic factors. The relative impact of these factors on tumor evolution changes over space and time, ultimately favoring the establishment of a neoplastic microenvironment that exhibits considerable genetic, phenotypic, and behavioral heterogeneity in all its components. Here, we discuss the main sources of intratumoral heterogeneity and its impact on the natural history of the disease, including sensitivity to treatment, as we delineate potential strategies to target such a detrimental feature of aggressive malignancies.

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Year:  2021        PMID： 33574607     DOI： 10.1038/s41591-021-01233-9

Source DB:  PubMed          Journal:  Nat Med        ISSN： 1078-8956            Impact factor:   87.241


  163 in total

1.  Clonal evolution of glioblastoma under therapy.

Authors:  Jiguang Wang; Emanuela Cazzato; Erik Ladewig; Veronique Frattini; Daniel I S Rosenbloom; Sakellarios Zairis; Francesco Abate; Zhaoqi Liu; Oliver Elliott; Yong-Jae Shin; Jin-Ku Lee; In-Hee Lee; Woong-Yang Park; Marica Eoli; Andrew J Blumberg; Anna Lasorella; Do-Hyun Nam; Gaetano Finocchiaro; Antonio Iavarone; Raul Rabadan
Journal:  Nat Genet       Date:  2016-06-06       Impact factor: 38.330

Review 2.  Mutational and Antigenic Landscape in Tumor Progression and Cancer Immunotherapy.

Authors:  Ilio Vitale; Antonella Sistigu; Gwenola Manic; Nils-Petter Rudqvist; Zlatko Trajanoski; Lorenzo Galluzzi
Journal:  Trends Cell Biol       Date:  2019-02-11       Impact factor: 20.808

3.  High-throughput single-cell ChIP-seq identifies heterogeneity of chromatin states in breast cancer.

Authors:  Kevin Grosselin; Adeline Durand; Justine Marsolier; Adeline Poitou; Elisabetta Marangoni; Fariba Nemati; Ahmed Dahmani; Sonia Lameiras; Fabien Reyal; Olivia Frenoy; Yannick Pousse; Marcel Reichen; Adam Woolfe; Colin Brenan; Andrew D Griffiths; Céline Vallot; Annabelle Gérard
Journal:  Nat Genet       Date:  2019-05-31       Impact factor: 38.330

4.  Single-Cell Transcriptome Analysis Reveals Disease-Defining T-cell Subsets in the Tumor Microenvironment of Classic Hodgkin Lymphoma.

Authors:  Tomohiro Aoki; Lauren C Chong; Katsuyoshi Takata; Katy Milne; Monirath Hav; Anthony Colombo; Elizabeth A Chavez; Michael Nissen; Xuehai Wang; Tomoko Miyata-Takata; Vivian Lam; Elena Viganò; Bruce W Woolcock; Adèle Telenius; Michael Y Li; Shannon Healy; Chanel Ghesquiere; Daniel Kos; Talia Goodyear; Johanna Veldman; Allen W Zhang; Jubin Kim; Saeed Saberi; Jiarui Ding; Pedro Farinha; Andrew P Weng; Kerry J Savage; David W Scott; Gerald Krystal; Brad H Nelson; Anja Mottok; Akil Merchant; Sohrab P Shah; Christian Steidl
Journal:  Cancer Discov       Date:  2019-12-19       Impact factor: 39.397

5.  Single-Cell RNA-Seq Reveals AML Hierarchies Relevant to Disease Progression and Immunity.

Authors:  Peter van Galen; Volker Hovestadt; Marc H Wadsworth Ii; Travis K Hughes; Gabriel K Griffin; Sofia Battaglia; Julia A Verga; Jason Stephansky; Timothy J Pastika; Jennifer Lombardi Story; Geraldine S Pinkus; Olga Pozdnyakova; Ilene Galinsky; Richard M Stone; Timothy A Graubert; Alex K Shalek; Jon C Aster; Andrew A Lane; Bradley E Bernstein
Journal:  Cell       Date:  2019-02-28       Impact factor: 41.582

Review 6.  Epigenetic plasticity and the hallmarks of cancer.

Authors:  William A Flavahan; Elizabeth Gaskell; Bradley E Bernstein
Journal:  Science       Date:  2017-07-21       Impact factor: 47.728

7.  Fibroblast Heterogeneity and Immunosuppressive Environment in Human Breast Cancer.

Authors:  Ana Costa; Yann Kieffer; Alix Scholer-Dahirel; Floriane Pelon; Brigitte Bourachot; Melissa Cardon; Philemon Sirven; Ilaria Magagna; Laetitia Fuhrmann; Charles Bernard; Claire Bonneau; Maria Kondratova; Inna Kuperstein; Andrei Zinovyev; Anne-Marie Givel; Maria-Carla Parrini; Vassili Soumelis; Anne Vincent-Salomon; Fatima Mechta-Grigoriou
Journal:  Cancer Cell       Date:  2018-02-15       Impact factor: 31.743

8.  Dysfunctional CD8 T Cells Form a Proliferative, Dynamically Regulated Compartment within Human Melanoma.

Authors:  Hanjie Li; Anne M van der Leun; Ido Yofe; Yaniv Lubling; Dikla Gelbard-Solodkin; Alexander C J van Akkooi; Marlous van den Braber; Elisa A Rozeman; John B A G Haanen; Christian U Blank; Hugo M Horlings; Eyal David; Yael Baran; Akhiad Bercovich; Aviezer Lifshitz; Ton N Schumacher; Amos Tanay; Ido Amit
Journal:  Cell       Date:  2018-12-27       Impact factor: 41.582

9.  Non-Genetic Intra-Tumor Heterogeneity Is a Major Predictor of Phenotypic Heterogeneity and Ongoing Evolutionary Dynamics in Lung Tumors.

Authors:  Anchal Sharma; Elise Merritt; Xiaoju Hu; Angelique Cruz; Chuan Jiang; Halle Sarkodie; Zhan Zhou; Jyoti Malhotra; Gregory M Riedlinger; Subhajyoti De
Journal:  Cell Rep       Date:  2019-11-19       Impact factor: 9.423

10.  Deciphering the genomic, epigenomic, and transcriptomic landscapes of pre-invasive lung cancer lesions.

Authors:  Vitor H Teixeira; Christodoulos P Pipinikas; Adam Pennycuick; Henry Lee-Six; Deepak Chandrasekharan; Jennifer Beane; Tiffany J Morris; Anna Karpathakis; Andrew Feber; Charles E Breeze; Paschalis Ntolios; Robert E Hynds; Mary Falzon; Arrigo Capitanio; Bernadette Carroll; Pascal F Durrenberger; Georgia Hardavella; James M Brown; Andy G Lynch; Henry Farmery; Dirk S Paul; Rachel C Chambers; Nicholas McGranahan; Neal Navani; Ricky M Thakrar; Charles Swanton; Stephan Beck; Phillip Jeremy George; Avrum Spira; Peter J Campbell; Christina Thirlwell; Sam M Janes
Journal:  Nat Med       Date:  2019-01-21       Impact factor: 53.440
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  88 in total

1.  Targeting NAD metabolism regulates extracellular adenosine levels to improve the cytotoxicity of CD8+ effector T cells in the tumor microenvironment of gastric cancer.

Authors:  Han-Yuan Liu; Fu-Hui Wang; Jian-Ming Liang; Yuan-Yuan Xiang; Shu-Hao Liu; Shi-Wei Zhang; Cheng-Ming Zhu; Yu-Long He; Chang-Hua Zhang
Journal:  J Cancer Res Clin Oncol       Date:  2022-07-01       Impact factor: 4.553

2.  D2HGDH-mediated D2HG catabolism enhances the anti-tumor activities of CAR-T cells in an immunosuppressive microenvironment.

Authors:  Quanjun Yang; Juan Hao; Mengyi Chi; Yaxian Wang; Jie Li; Jinlu Huang; Jianping Zhang; Mengqi Zhang; Jin Lu; Shumin Zhou; Ting Yuan; Zan Shen; Shuier Zheng; Cheng Guo
Journal:  Mol Ther       Date:  2022-01-07       Impact factor: 11.454

Review 3.  Targeting oncogene and non-oncogene addiction to inflame the tumour microenvironment.

Authors:  Giulia Petroni; Aitziber Buqué; Lisa M Coussens; Lorenzo Galluzzi
Journal:  Nat Rev Drug Discov       Date:  2022-03-15       Impact factor: 84.694

Review 4.  Radiotherapy as a tool to elicit clinically actionable signalling pathways in cancer.

Authors:  Giulia Petroni; Lewis C Cantley; Laura Santambrogio; Silvia C Formenti; Lorenzo Galluzzi
Journal:  Nat Rev Clin Oncol       Date:  2021-11-24       Impact factor: 66.675

5.  Spatial distribution and functional analysis define the action pathway of Tim-3/Tim-3 ligands in tumor development.

Authors:  Tixiao Wang; Jie Zhang; Na Li; Mengzhen Li; Shuaiya Ma; Siyu Tan; Xiaowei Guo; Zehua Wang; Zhuanchang Wu; Lifen Gao; Chunhong Ma; Xiaohong Liang
Journal:  Mol Ther       Date:  2021-11-19       Impact factor: 11.454

6.  Clinical significance and immunogenomic landscape analysis of glycolysis-associated prognostic model to guide clinical therapy in hepatocellular carcinoma.

Authors:  Qingshan Chen; Leilei Bao; Yueying Huang; Lei Lv; Guoqing Zhang; Yi Chen
Journal:  J Gastrointest Oncol       Date:  2022-06

7.  PKCλ/ι inhibition activates an ULK2-mediated interferon response to repress tumorigenesis.

Authors:  Juan F Linares; Xiao Zhang; Anxo Martinez-Ordoñez; Angeles Duran; Hiroto Kinoshita; Hiroaki Kasashima; Naoko Nakanishi; Yuki Nakanishi; Ryan Carelli; Luca Cappelli; Esperanza Arias; Masakazu Yashiro; Masaichi Ohira; Sanjay Patel; Giorgio Inghirami; Massimo Loda; Ana Maria Cuervo; Maria T Diaz-Meco; Jorge Moscat
Journal:  Mol Cell       Date:  2021-09-23       Impact factor: 17.970

Review 8.  The Mesangial cell - the glomerular stromal cell.

Authors:  Shimrit Avraham; Ben Korin; Jun-Jae Chung; Leif Oxburgh; Andrey S Shaw
Journal:  Nat Rev Nephrol       Date:  2021-09-10       Impact factor: 28.314

9.  Single-cell atlas of tumor cell evolution in response to therapy in hepatocellular carcinoma and intrahepatic cholangiocarcinoma.

Authors:  Lichun Ma; Limin Wang; Subreen A Khatib; Ching-Wen Chang; Sophia Heinrich; Dana A Dominguez; Marshonna Forgues; Julián Candia; Maria O Hernandez; Michael Kelly; Yongmei Zhao; Bao Tran; Jonathan M Hernandez; Jeremy L Davis; David E Kleiner; Bradford J Wood; Tim F Greten; Xin Wei Wang
Journal:  J Hepatol       Date:  2021-06-30       Impact factor: 25.083

Review 10.  Immune Microenvironment and Genetics in Malignant Pleural Mesothelioma.

Authors:  Benjamin Wadowski; Raphael Bueno; Assunta De Rienzo
Journal:  Front Oncol       Date:  2021-06-11       Impact factor: 6.244
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