María I Fontalba-Romero1, Soledad Lopez-Enriquez2,3, Ana Lago-Sampedro1,3, Eva García-Escobar1,3,4, Ricardo L Pastori5, Juan Domínguez-Bendala5, Silvia Álvarez-Cubela5, Sergio Valdes1,3,4, Gemma Rojo1,3,4, Eduardo Garcia-Fuentes3,6, María T Labajos-Manzanares7, Sara García-Serrano1,3,4. 1. Unidad de Gestión Clínica de Endocrinología y Nutrición, Hospital Regional Universitario, 29010 Málaga, Spain. 2. Departamento de Bioquímica Médica, Biología Molecular e Inmunología, Facultad de Medicina, Universidad de Sevilla, 41009 Sevilla, Spain. 3. Instituto de Investigación Biomédica de Málaga-IBIMA, 29010 Málaga, Spain. 4. CIBER de Diabetes y Enfermedades Metabólicas (CIBERDEM), 29009 Málaga, Spain. 5. Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL 33136, USA. 6. Unidad de Gestión Clínica de Aparato Digestivo, Hospital Universitario Virgen de la Victoria, 29010 Málaga, Spain. 7. Faculty of Health Sciences, School of Medicine, University of Málaga, 29071 Málaga, Spain.
Abstract
BACKGROUND: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). METHODS: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. RESULTS: There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). CONCLUSIONS: There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food.
BACKGROUND: The Mediterranean diet (MD) could be involved in the regulation of different miRNAs related to metabolic syndrome (MS). METHODS: We analyzed the serum level of mir-let7a-5p, mir-21, mir-590, mir-107 and mir-192 in patients with morbid obesity and its association with the MD and MS. RESULTS: There is an association between the adherence to MD and higher serum levels of mir-590. Mir-590 was lower in those patients who consumed >2 commercial pastries/week. Mir-let7a was lower in those who consumed ≥1 sweetened drinks, in those who consumed ≥3 pieces of fruit/day and in those who consumed less red than white meat. A lower mir-590 and mir-let7a, and a higher mir-192 level, were found in patients who met the high-density lipoprotein cholesterol (HDL) criterion of MS. A higher mir-192 was found in those patients who met the triglyceride criterion of MS and in those with type 2 diabetes (T2DM). CONCLUSIONS: There is an association between specific serum levels of miRNAs and the amount and kind of food intake related to MD. Mir-590 was positively associated with a healthy metabolic profile and type of diet, while mir-192 was positively associated with a worse metabolic profile. These associations could be suggestive of a possible modulation of these miRNAs by food.
Authors: P Gnagnarella; D Dragà; A M Misotti; S Sieri; L Spaggiari; E Cassano; F Baldini; L Soldati; P Maisonneuve Journal: Nutr Metab Cardiovasc Dis Date: 2018-06-18 Impact factor: 4.222
Authors: Marcelina Párrizas; Laura Brugnara; Yaiza Esteban; Alba González-Franquesa; Sílvia Canivell; Serafín Murillo; Elizabeth Gordillo-Bastidas; Roser Cussó; Joan A Cadefau; Pablo M García-Roves; Joan-Marc Servitja; Anna Novials Journal: J Clin Endocrinol Metab Date: 2014-12-22 Impact factor: 5.958