Vitória Paixão1, Ewin B Almeida1, Jonatas B Amaral1, Tamaris Roseira1,2, Fernanda R Monteiro1,2, Roberta Foster1,2, Adriane Sperandio2, Marcelo Rossi1, Gislene R Amirato1, Carlos A F Santos3, Renier S Pires4, Fabyano B Leal5, Edison L Durigon5,6, Danielle B L Oliveira5,7, Rodolfo P Vieira8,9,10, Mauro Vaisberg1, Juliana M B Santos10, André L L Bachi1,4,8. 1. Department of Otorhinolaryngology, ENT Lab, Federal University of São Paulo (UNIFESP), São Paulo 04021-001, Brazil. 2. Method Faculty of São Paulo (FAMESP), São Paulo 04046-200, Brazil. 3. Department of Medicine, Geriatry, Paulista School of Medicine (EPM), São Paulo 04023-062, Brazil. 4. Post-Graduation Program in Health Science, Santo Amaro University (UNISA), São Paulo 04743-030, Brazil. 5. Institute of Biomedical Science, University of São Paulo (USP), São Paulo 05508-060, Brazil. 6. Scientific Platform Pasteur, University of São Paulo (USP), São Paulo 05508-060, Brazil. 7. Hospital Israelita Albert Einstein, São Paulo 05652-900, Brazil. 8. Brazilian Institute of Teaching and Research in Pulmonary and Exercise Immunology (IBEPIPE), São Paulo 12245-520, Brazil. 9. Post-Graduation Program in Bioengineering and Biomedical Engineering, Universidade Brasil, São Paulo 15600-000, Brazil. 10. Post-Graduation Program in Science of Human and Rehabilitation, Federal University of São Paulo (UNIFESP), Santos 11015-020, Brazil.
Abstract
BACKGROUND: Although glutamine is able to improve the immune response, its action in the upper airway immunity against the influenza virus vaccine remains unclear. Therefore, we aimed to evaluate the L-glutamine supplementation effect on the mucosal immune/inflammatory response of elderly subjects vaccinated against the influenza virus. METHODS: Saliva sampling from 83 physically active elderly volunteers were collected pre- and 30 days after influenza virus vaccination and supplementation with L-glutamine (Gln, n = 42) or placebo (PL, n = 41). RESULTS: Gln group showed higher salivary levels of interleukin (IL)-17, total secretory immunoglobulin A (SIgA), and specific-SIgA post-vaccination than values found pre-vaccination and in the PL group post-vaccination. Whereas higher salivary levels of IL-6 and IL-10 were observed post-vaccination in the Gln group, IL-37 levels were lower post-vaccination in both groups than the values pre-vaccination. Tumor necrosis factor (TNF)-α levels were unchanged. Positive correlations between IL-6 and IL-10 were found in all volunteer groups pre- and post-vaccination and also between IL-17 and IL-6 or IL-10 in the Gln group post-vaccination. A negative correlation between IL-37 and IL-10 was found pre- and post-vaccination in the PL group. CONCLUSION: Gln supplementation was able to modulate salivary cytokine profile and increase SIgA levels, both total and specific to the influenza virus vaccine, in physically active elderly subjects.
BACKGROUND: Although glutamine is able to improve the immune response, its action in the upper airway immunity against the influenza virus vaccine remains unclear. Therefore, we aimed to evaluate the L-glutamine supplementation effect on the mucosal immune/inflammatory response of elderly subjects vaccinated against the influenza virus. METHODS: Saliva sampling from 83 physically active elderly volunteers were collected pre- and 30 days after influenza virus vaccination and supplementation with L-glutamine (Gln, n = 42) or placebo (PL, n = 41). RESULTS:Gln group showed higher salivary levels of interleukin (IL)-17, total secretory immunoglobulin A (SIgA), and specific-SIgA post-vaccination than values found pre-vaccination and in the PL group post-vaccination. Whereas higher salivary levels of IL-6 and IL-10 were observed post-vaccination in the Gln group, IL-37 levels were lower post-vaccination in both groups than the values pre-vaccination. Tumor necrosis factor (TNF)-α levels were unchanged. Positive correlations between IL-6 and IL-10 were found in all volunteer groups pre- and post-vaccination and also between IL-17 and IL-6 or IL-10 in the Gln group post-vaccination. A negative correlation between IL-37 and IL-10 was found pre- and post-vaccination in the PL group. CONCLUSION:Gln supplementation was able to modulate salivary cytokine profile and increase SIgA levels, both total and specific to the influenza virus vaccine, in physically active elderly subjects.
Authors: Jerrald L Rector; Jennifer B Dowd; Adrian Loerbroks; Victoria E Burns; Paul A Moss; Marc N Jarczok; Tobias Stalder; Kristina Hoffman; Joachim E Fischer; Jos A Bosch Journal: Brain Behav Immun Date: 2014-01-26 Impact factor: 7.217
Authors: Hiromasa Hamada; Maria de la Luz Garcia-Hernandez; Joyce B Reome; Sara K Misra; Tara M Strutt; Kai K McKinstry; Andrea M Cooper; Susan L Swain; Richard W Dutton Journal: J Immunol Date: 2009-03-15 Impact factor: 5.422
Authors: Eduardo S Felismino; Juliana M B Santos; Marcelo Rossi; Carlos A F Santos; Edison L Durigon; Danielle B L Oliveira; Luciano M Thomazelli; Fernanda R Monteiro; Adriane Sperandio; Juliana S Apostólico; Carolina N França; Jonatas B Amaral; Gislene R Amirato; Rodolfo P Vieira; Mauro Vaisberg; André L L Bachi Journal: Front Immunol Date: 2021-10-12 Impact factor: 7.561
Authors: Adriana Caldo-Silva; Guilherme Eustáquio Furtado; Matheus Uba Chupel; André L L Bachi; Marcelo P de Barros; Rafael Neves; Emanuele Marzetti; Alain Massart; Ana Maria Teixeira Journal: Nutrients Date: 2021-03-28 Impact factor: 5.717