Malgorzata Gajdzis1, Stamatios Theocharis2,3, Jerzy Klijanienko3, Nathalie Cassoux4, Sophie Gardrat5, Piotr Donizy6, Radoslaw Kaczmarek1, Pawel Gajdzis3,6. 1. Department of Ophthalmology, Wroclaw Medical University, 50-556 Wroclaw, Poland. 2. First Department of Pathology, National and Kapodistrian University of Athens, 15772 Athens, Greece. 3. Department of Pathology, Curie Institute, 75005 Paris, France. 4. Department of Ophthalmology, Institut Curie, 75005 Paris, France. 5. Department of Biopathology, Institut Curie, PSL Research University, 75005 Paris, France. 6. Department of Pathomorphology and Oncological Cytology, Wroclaw Medical University, 50-556 Wroclaw, Poland.
Abstract
BACKGROUND: Uveal melanoma is the most common primary intraocular malignancy in adults. In advanced cases, the prognosis is very poor. Thus far, no effective methods of pharmacotherapy of this cancer have been found. The aim of the study was to evaluate the expression of PARP-1, the best-known member of the family of poly(ADP-ribose) polymerases, in uveal melanoma and its associations with clinicopathological parameters, overall survival, and disease-free survival. METHODS: The study included 91 patients who underwent enucleation due to uveal melanoma. PARP-1 expression was assessed by immunohistochemistry. RESULTS: High PARP-1 expression was associated with more frequent chromosome 3 loss, higher histopathological grade, bigger tumor size, and absence of intrascleral extension. High PARP-1 expression was associated with shorter overall survival time and disease-free survival time. CONCLUSIONS: The above findings indicate that high expression of PARP-1 can be considered as an unfavorable prognostic factor in uveal melanoma.
BACKGROUND:Uveal melanoma is the most common primary intraocular malignancy in adults. In advanced cases, the prognosis is very poor. Thus far, no effective methods of pharmacotherapy of this cancer have been found. The aim of the study was to evaluate the expression of PARP-1, the best-known member of the family of poly(ADP-ribose) polymerases, in uveal melanoma and its associations with clinicopathological parameters, overall survival, and disease-free survival. METHODS: The study included 91 patients who underwent enucleation due to uveal melanoma. PARP-1 expression was assessed by immunohistochemistry. RESULTS: High PARP-1 expression was associated with more frequent chromosome 3 loss, higher histopathological grade, bigger tumor size, and absence of intrascleral extension. High PARP-1 expression was associated with shorter overall survival time and disease-free survival time. CONCLUSIONS: The above findings indicate that high expression of PARP-1 can be considered as an unfavorable prognostic factor in uveal melanoma.
Authors: Gyula Timinszky; Susanne Till; Paul O Hassa; Michael Hothorn; Georg Kustatscher; Bianca Nijmeijer; Julien Colombelli; Matthias Altmeyer; Ernst H K Stelzer; Klaus Scheffzek; Michael O Hottiger; Andreas G Ladurner Journal: Nat Struct Mol Biol Date: 2009-08-13 Impact factor: 15.369
Authors: Dragana Ahel; Zuzana Horejsí; Nicola Wiechens; Sophie E Polo; Elisa Garcia-Wilson; Ivan Ahel; Helen Flynn; Mark Skehel; Stephen C West; Stephen P Jackson; Tom Owen-Hughes; Simon J Boulton Journal: Science Date: 2009-08-06 Impact factor: 47.728
Authors: M Salemi; A Galia; F Fraggetta; C La Corte; P Pepe; S La Vignera; G Improta; P Bosco; A E Calogero Journal: Eur J Histochem Date: 2013-04-15 Impact factor: 3.188
Authors: Yuko Nakagawa; Anna S Sedukhina; Naoki Okamoto; Satoi Nagasawa; Nao Suzuki; Tomohiko Ohta; Hiroyoshi Hattori; Marta Roche-Molina; Ana J Narváez; Anand D Jeyasekharan; Juan A Bernal; Ko Sato Journal: Oncotarget Date: 2015-02-28
Authors: Piotr Donizy; Cheng-Lin Wu; Jason Mull; Masakazu Fujimoto; Agata Chłopik; Yan Peng; Sara C Shalin; M Angelica Selim; Susana Puig; Maria-Teresa Fernandez-Figueras; Christopher R Shea; Wojciech Biernat; Janusz Ryś; Andrzej Marszalek; Mai P Hoang Journal: Cells Date: 2020-05-05 Impact factor: 6.600