Francesco Petrella1,2, Monica Casiraghi1, Davide Radice3, Andrea Cara1, Gabriele Maffeis1, Elena Prisciandaro1, Stefania Rizzo4,5, Lorenzo Spaggiari1,2. 1. Department of Thoracic Surgery, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy. 2. Department of Oncology and Hemato-Oncology, Università degli Studi di Milano, 20141 Milan, Italy. 3. Department of Biostatistics, IEO European Institute of Oncology IRCCS, 20141 Milan, Italy. 4. Department of Radiology, Ente Ospedaliero Cantonale (EOC) Istituto di Imaging della Svizzera Italiana (IIMSI), 6903 Lugano, Switzerland. 5. Università della Svizzera Italiana, 6903 Lugano, Switzerland.
Abstract
BACKGROUND: The ratio of hemoglobin to red cell distribution width (HRR) has been described as an effective prognostic factor in several types of cancer. The aim of this study was to investigate the prognostic role of preoperative HRR in resected-lung-adenocarcinoma patients. METHODS: We enrolled 342 consecutive patients. Age, sex, surgical resection, adjuvant treatments, pathological stage, preoperative hemoglobin, red cell distribution width, and their ratio were recorded for each patient. RESULTS: Mean age was 66 years (SD: 9.0). There were 163 females (47.1%); 169 patients (49.4%) had tumors at stage I, 71 (20.8%) at stage II, and 102 (29.8%) at stage III. In total, 318 patients (93.0%) underwent lobectomy, and 24 (7.0%) pneumonectomy. Disease-free survival multivariable analysis disclosed an increased hazard ratio (HR) of relapse for preoperative HRR lower than 1.01 (HR = 2.20, 95%CI: (1.30-3.72), p = 0.004), as well as for N1 single-node (HR = 2.55, 95%CI: (1.33-4.90), p = 0.005) and multiple-level lymph node involvement compared to N0 for both N1 (HR = 9.16, 95%CI:(3.65-23.0), p < 0.001) and N2 (HR = 10.5, 95%CI:(3.44-32.2, p < 0.001). CONCLUSION: Pre-operative HRR is an effective prognostic factor of disease-free survival in resected-lung-adenocarcinoma patients, together with the level of pathologic node involvement.
BACKGROUND: The ratio of hemoglobin to red cell distribution width (HRR) has been described as an effective prognostic factor in several types of cancer. The aim of this study was to investigate the prognostic role of preoperative HRR in resected-lung-adenocarcinomapatients. METHODS: We enrolled 342 consecutive patients. Age, sex, surgical resection, adjuvant treatments, pathological stage, preoperative hemoglobin, red cell distribution width, and their ratio were recorded for each patient. RESULTS: Mean age was 66 years (SD: 9.0). There were 163 females (47.1%); 169 patients (49.4%) had tumors at stage I, 71 (20.8%) at stage II, and 102 (29.8%) at stage III. In total, 318 patients (93.0%) underwent lobectomy, and 24 (7.0%) pneumonectomy. Disease-free survival multivariable analysis disclosed an increased hazard ratio (HR) of relapse for preoperative HRR lower than 1.01 (HR = 2.20, 95%CI: (1.30-3.72), p = 0.004), as well as for N1 single-node (HR = 2.55, 95%CI: (1.33-4.90), p = 0.005) and multiple-level lymph node involvement compared to N0 for both N1 (HR = 9.16, 95%CI:(3.65-23.0), p < 0.001) and N2 (HR = 10.5, 95%CI:(3.44-32.2, p < 0.001). CONCLUSION: Pre-operative HRR is an effective prognostic factor of disease-free survival in resected-lung-adenocarcinomapatients, together with the level of pathologic node involvement.
Entities:
Keywords:
disease-free survival; hemoglobin/red blood cell distribution width ratio (HRR); lung adenocarcinoma
Authors: Jelena Ivanovic; Ahmed Al-Hussaini; Derar Al-Shehab; Jennifer Threader; Patrick James Villeneuve; Tim Ramsay; Donna E Maziak; Sebastian Gilbert; Farid M Shamji; R Sudhir Sundaresan; Andrew J E Seely Journal: Ann Thorac Surg Date: 2011-02 Impact factor: 4.330
Authors: Julia Riedl; Florian Posch; Oliver Königsbrügge; Felix Lötsch; Eva-Maria Reitter; Ernst Eigenbauer; Christine Marosi; Ilse Schwarzinger; Christoph Zielinski; Ingrid Pabinger; Cihan Ay Journal: PLoS One Date: 2014-10-27 Impact factor: 3.240