Literature DB >> 33572369

Diagnosing Burn Wounds Infection: The Practice Gap & Advances with MolecuLight Bacterial Imaging.

Nawras Farhan1, Steven Jeffery2.   

Abstract

Burn injuries constitute a critical economic burden on healthcare infrastructures worldwide. They are often associated with high mortality rates due to severe complications. Infection is the most common complication, highlighting the importance of prompt and precise diagnosis in order to prevent detrimental consequences and to optimize patient outcomes. Here we examine the current standard of care for diagnosing infection in both burn and chronic wounds followed by an investigation into the research surrounding a relatively new technique for bacterial detection, fluorescence imaging. With five years of published research on bacterial fluorescence imaging (MolecuLight i:X device), we have summarized and analysed the validity of the procedure and compared it to the current standard of care; clinical assessment and microbiological analysis. We highlight the benefits that could be obtained through the use of this technology as well as the limitations and the feasibility of incorporating this novel procedure into the standard of care.

Entities:  

Keywords:  MolecuLight i:X; bacteria; burns; fluorescence; imaging; wounds

Year:  2021        PMID: 33572369      PMCID: PMC7916143          DOI: 10.3390/diagnostics11020268

Source DB:  PubMed          Journal:  Diagnostics (Basel)        ISSN: 2075-4418


  61 in total

Review 1.  Chronic Wound Biofilms: Pathogenesis and Potential Therapies.

Authors:  Allie Clinton; Tammy Carter
Journal:  Lab Med       Date:  2015

2.  Optimising the design of a broad-band light source for the treatment of skin.

Authors:  Marc Clement; Gwenaelle Daniel; Mario Trelles
Journal:  J Cosmet Laser Ther       Date:  2005-12       Impact factor: 2.247

3.  Does this patient have an infection of a chronic wound?

Authors:  Madhuri Reddy; Sudeep S Gill; Wei Wu; Sunila R Kalkar; Paula A Rochon
Journal:  JAMA       Date:  2012-02-08       Impact factor: 56.272

4.  Using a hand-held black-light source instead of a Wood's lamp.

Authors:  Feroze Kaliyadan; Joel Kuruvilla
Journal:  J Am Acad Dermatol       Date:  2015-06       Impact factor: 11.527

5.  Wood lamp examination.

Authors:  David Ponka; Faisal Baddar
Journal:  Can Fam Physician       Date:  2012-09       Impact factor: 3.275

6.  Facial follicular porphyrin fluorescence: correlation with age and density of Propionibacterium acnes.

Authors:  K J McGinley; G F Webster; J J Leyden
Journal:  Br J Dermatol       Date:  1980-04       Impact factor: 9.302

7.  Utility of MolecuLight i:X for Managing Bacterial Burden in Pediatric Burns.

Authors:  Nawras Farhan; Steven Jeffery
Journal:  J Burn Care Res       Date:  2020-02-19       Impact factor: 1.845

8.  Comparison of chronic wound culture techniques: swab versus curetted tissue for microbial recovery.

Authors:  Maria Elisa Smith; Natanya Robinowitz; Patrick Chaulk; Kristine Johnson
Journal:  Br J Community Nurs       Date:  2014-09

9.  Use of a bacterial fluorescence imaging device: wound measurement, bacterial detection and targeted debridement.

Authors:  Rose Raizman; Danielle Dunham; Liis Lindvere-Teene; Laura M Jones; Kim Tapang; Ron Linden; Monique Y Rennie
Journal:  J Wound Care       Date:  2019-12-02       Impact factor: 2.072

10.  Effect of wavelength and beam width on penetration in light-tissue interaction using computational methods.

Authors:  Caerwyn Ash; Michael Dubec; Kelvin Donne; Tim Bashford
Journal:  Lasers Med Sci       Date:  2017-09-12       Impact factor: 3.161

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  3 in total

Review 1.  Resistance Is Not Futile: The Role of Quorum Sensing Plasticity in Pseudomonas aeruginosa Infections and Its Link to Intrinsic Mechanisms of Antibiotic Resistance.

Authors:  Kayla A Simanek; Jon E Paczkowski
Journal:  Microorganisms       Date:  2022-06-18

2.  Diagnosis and treatment of the invasive extension of bacteria (cellulitis) from chronic wounds utilising point-of-care fluorescence imaging.

Authors:  Charles A Andersen; Katherine McLeod; Rowena Steffan
Journal:  Int Wound J       Date:  2021-10-05       Impact factor: 3.099

3.  The Co-Culture of Staphylococcal Biofilm and Fibroblast Cell Line: The Correlation of Biological Phenomena with Metabolic NMR1 Footprint.

Authors:  Joanna Czajkowska; Adam Junka; Jakub Hoppe; Monika Toporkiewicz; Andrzej Pawlak; Paweł Migdał; Monika Oleksy-Wawrzyniak; Karol Fijałkowski; Marcin Śmiglak; Agata Markowska-Szczupak
Journal:  Int J Mol Sci       Date:  2021-05-29       Impact factor: 5.923

  3 in total

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