Literature DB >> 33572282

Photophysical Properties of Protoporphyrin IX, Pyropheophorbide-a and Photofrin® in Different Conditions.

Bauyrzhan Myrzakhmetov1,2, Philippe Arnoux1, Serge Mordon3, Samir Acherar4, Irina Tsoy2, Céline Frochot1.   

Abstract

Photodynamic therapy (PDT) is an innovative treatment of malignant or diseased tissues. The effectiveness of PDT depends on light dosimetry, oxygen availability, and properties of the photosensitizer (PS). Depending on the medium, photophysical properties of the PS can change leading to increase or decrease in fluorescence emission and formation of reactive oxygen species (ROS) especially singlet oxygen (1O2). In this study, the influence of solvent polarity, viscosity, concentration, temperature, and pH medium on the photophysical properties of protoporphyrin IX, pyropheophorbide-a, and Photofrin® were investigated by UV-visible absorption, fluorescence emission, singlet oxygen emission, and time-resolved fluorescence spectroscopies.

Entities:  

Keywords:  Photofrin®; absorption; fluorescence; photodynamic therapy; protoporphyrin IX; pyropheophorbide-a; singlet oxygen

Year:  2021        PMID： 33572282      PMCID： PMC7914864          DOI： 10.3390/ph14020138

Source DB:  PubMed          Journal:  Pharmaceuticals (Basel)        ISSN： 1424-8247


  36 in total

Review 1.  A compilation of singlet oxygen yields from biologically relevant molecules.

Authors:  R W Redmond; J N Gamlin
Journal:  Photochem Photobiol       Date:  1999-10       Impact factor: 3.421

2.  Singlet Oxygen Photophysics in Liquid Solvents: Converging on a Unified Picture.

Authors:  Mikkel Bregnhøj; Michael Westberg; Boris F Minaev; Peter R Ogilby
Journal:  Acc Chem Res       Date:  2017-07-21       Impact factor: 22.384

3.  Time-resolved fluorescence spectroscopy of hematoporphyrin, mesoporphyrin, pheophorbide a and chlorin e6 in ethanol and aqueous solution.

Authors:  B Roeder; H Wabnitz
Journal:  J Photochem Photobiol B       Date:  1987-09       Impact factor: 6.252

4.  Nanoscopic micelle delivery improves the photophysical properties and efficacy of photodynamic therapy of protoporphyrin IX.

Authors:  Huiying Ding; Baran D Sumer; Chase W Kessinger; Ying Dong; Gang Huang; David A Boothman; Jinming Gao
Journal:  J Control Release       Date:  2011-01-10       Impact factor: 9.776

Review 5.  New photosensitizers for photodynamic therapy.

Authors:  Heidi Abrahamse; Michael R Hamblin
Journal:  Biochem J       Date:  2016-02-15       Impact factor: 3.857

6.  Long-term outcomes of the randomized controlled trial comparing 5-aminolaevulinic acid and Photofrin photodynamic therapy for Barrett's oesophagus related neoplasia.

Authors:  Darina Kohoutova; Rehan Haidry; Matthew Banks; Mohammed Adil Butt; Jason Dunn; Sally Thorpe; Laurence Lovat
Journal:  Scand J Gastroenterol       Date:  2017-11-21       Impact factor: 2.423

7.  Effects of the oxygenation level on formation of different reactive oxygen species during photodynamic therapy.

Authors:  Michael Price; Lance Heilbrun; David Kessel
Journal:  Photochem Photobiol       Date:  2013-01-25       Impact factor: 3.421

8.  Physical and chemical properties of pyropheophorbide-a methyl ester in ethanol, phosphate buffer and aqueous dispersion of small unilamellar dimyristoyl-L-alpha-phosphatidylcholine vesicles.

Authors:  Lisiane Delanaye; Mohamed Ali Bahri; Francis Tfibel; Marie-Pierre Fontaine-Aupart; Ange Mouithys-Mickalad; Bélinda Heine; Jacques Piette; Maryse Hoebeke
Journal:  Photochem Photobiol Sci       Date:  2006-01-12       Impact factor: 3.982

Review 9.  Porphyrin photosensitizers in photodynamic therapy and its applications.

Authors:  Jiayuan Kou; Dou Dou; Liming Yang
Journal:  Oncotarget       Date:  2017-08-11

10.  Ultra-small Pyropheophorbide-a Nanodots for Near-infrared Fluorescence/Photoacoustic Imaging-guided Photodynamic Therapy.

Authors:  Kittipan Siwawannapong; Rui Zhang; Huali Lei; Qiutong Jin; Wantao Tang; Ziliang Dong; Rung-Yi Lai; Zhuang Liu; Anyanee Kamkaew; Liang Cheng
Journal:  Theranostics       Date:  2020-01-01       Impact factor: 11.556
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  3 in total

1.  In vitro Assessment of Solar Filters for Erythropoietic Protoporphyria in the Action Spectrum of Protoporphyrin IX.

Authors:  Alvise Sernicola; Elena Cama; Maria Guglielmina Pelizzo; Enrico Tessarolo; Annamaria Nicolli; Giulia Viero; Mauro Alaibac
Journal:  Front Med (Lausanne)       Date:  2021-12-20

Review 2.  Design Principles Governing the Development of Theranostic Anticancer Agents and Their Nanoformulations with Photoacoustic Properties.

Authors:  Stavroula G Kyrkou; Eirinaios I Vrettos; Dimitris Gorpas; Timothy Crook; Nelofer Syed; Andreas G Tzakos
Journal:  Pharmaceutics       Date:  2022-02-04       Impact factor: 6.321

Review 3.  Daylight-PDT: everything under the sun.

Authors:  Dana Beiki; Ian M Eggleston; Charareh Pourzand
Journal:  Biochem Soc Trans       Date:  2022-04-29       Impact factor: 4.919
  3 in total

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