Literature DB >> 33571246

Transmission of the atypical/Nor98 scrapie agent to Suffolk sheep with VRQ/ARQ, ARQ/ARQ, and ARQ/ARR genotypes.

Eric D Cassmann1, Najiba Mammadova1, S Jo Moore1, Sylvie Benestad2, Justin J Greenlee1.   

Abstract

Scrapie is a transmissible spongiform encephalopathy that occurs in sheep. Atypical/Nor98 scrapie occurs in sheep that tend to be resistant to classical scrapie and it is thought to occur spontaneously. The purpose of this study was to test the transmission of the Atypical/Nor98 scrapie agent in three genotypes of Suffolk sheep and characterize the distribution of misfolded prion protein (PrPSc). Ten sheep were intracranially inoculated with brain homogenate from a sheep with Atypical/Nor98 scrapie. All sheep with the ARQ/ARQ and ARQ/ARR genotypes developed Atypical/Nor98 scrapie confirmed by immunohistochemistry, and one sheep with the VRQ/ARQ genotype had detectable PrPSc consistent with Atypical/Nor98 scrapie at the experimental endpoint of 8 years. Sheep with mild early accumulations of PrPSc in the cerebellum had concomitant retinal PrPSc. Accordingly, large amounts of retinal PrPSc were identified in clinically affected sheep and sheep with dense accumulations of PrPSc in the cerebellum.

Entities:  

Mesh：

Substances：

Year:  2021        PMID： 33571246      PMCID： PMC7877616          DOI： 10.1371/journal.pone.0246503

Source DB:  PubMed          Journal:  PLoS One        ISSN： 1932-6203            Impact factor:   3.240


  31 in total

1.  Estimation of the relative risk of developing clinical scrapie: the role of prion protein (PrP) genotype and selection bias.

Authors:  S C Tongue; D U Pfeiffer; R Warner; H Elliott; V Del Rio Vilas
Journal:  Vet Rec       Date:  2006-01-14       Impact factor: 2.695

2.  Validation of monoclonal antibody F99/97.6.1 for immunohistochemical staining of brain and tonsil in mule deer (Odocoileus hemionus) with chronic wasting disease.

Authors:  T R Spraker; K I O'Rourke; A Balachandran; R R Zink; B A Cummings; M W Miller; B E Powers
Journal:  J Vet Diagn Invest       Date:  2002-01       Impact factor: 1.279

3.  PrP genotype contributes to determining survival times of sheep with natural scrapie.

Authors:  A Bossers; B E Schreuder; I H Muileman; P B Belt; M A Smits
Journal:  J Gen Virol       Date:  1996-10       Impact factor: 3.891

4.  Epidemiological and genetical differences between classical and atypical scrapie cases.

Authors:  Gesine Lühken; Anne Buschmann; Horst Brandt; Martin Eiden; Martin H Groschup; Georg Erhardt
Journal:  Vet Res       Date:  2006-12-08       Impact factor: 3.683

5.  Identification of five allelic variants of the sheep PrP gene and their association with natural scrapie.

Authors:  P B Belt; I H Muileman; B E Schreuder; J Bos-de Ruijter; A L Gielkens; M A Smits
Journal:  J Gen Virol       Date:  1995-03       Impact factor: 3.891

6.  Oral inoculation of neonatal Suffolk sheep with the agent of classical scrapie results in PrP(Sc) accumulation in sheep with the PRNP ARQ/ARQ but not the ARQ/ARR genotype.

Authors:  Justin J Greenlee; Jodi D Smith; Amir N Hamir
Journal:  Res Vet Sci       Date:  2016-02-24       Impact factor: 2.534

Review 7.  Review: Update on Classical and Atypical Scrapie in Sheep and Goats.

Authors:  Justin J Greenlee
Journal:  Vet Pathol       Date:  2018-09-10       Impact factor: 2.221

8.  Experimental oral transmission of atypical scrapie to sheep.

Authors:  Marion M Simmons; S Jo Moore; Timm Konold; Lisa Thurston; Linda A Terry; Leigh Thorne; Richard Lockey; Chris Vickery; Stephen A C Hawkins; Melanie J Chaplin; John Spiropoulos
Journal:  Emerg Infect Dis       Date:  2011-05       Impact factor: 6.883

9.  First case of atypical scrapie in a goat in Japan.

Authors:  Yuichi Matsuura; Kohtaro Miyazawa; Morikazu Imamura; Takashi Yokoyama; Yoshifumi Iwamaru
Journal:  J Vet Med Sci       Date:  2019-05-15       Impact factor: 1.267

10.  Atypical scrapie in sheep from a UK research flock which is free from classical scrapie.

Authors:  Hugh A Simmons; Marion M Simmons; Yvonne I Spencer; Melanie J Chaplin; Gill Povey; Andrew Davis; Angel Ortiz-Pelaez; Nora Hunter; Danny Matthews; Anthony E Wrathall
Journal:  BMC Vet Res       Date:  2009-02-10       Impact factor: 2.741
View more
  6 in total

1.  A single amino acid residue in bank vole prion protein drives permissiveness to Nor98/atypical scrapie and the emergence of multiple strain variants.

Authors:  Laura Pirisinu; Michele Angelo Di Bari; Claudia D'Agostino; Ilaria Vanni; Geraldina Riccardi; Stefano Marcon; Gabriele Vaccari; Barbara Chiappini; Sylvie L Benestad; Umberto Agrimi; Romolo Nonno
Journal:  PLoS Pathog       Date:  2022-06-22       Impact factor: 7.464

Review 2.  Chronic Wasting Disease (CWD) in Cervids and the Consequences of a Mutable Protein Conformation.

Authors:  Christopher J Silva
Journal:  ACS Omega       Date:  2022-04-04

Review 3.  Differential Accumulation of Misfolded Prion Strains in Natural Hosts of Prion Diseases.

Authors:  Zoe J Lambert; Justin J Greenlee; Eric D Cassmann; M Heather West Greenlee
Journal:  Viruses       Date:  2021-12-07       Impact factor: 5.048

Review 4.  Classical and Atypical Scrapie in Sheep and Goats. Review on the Etiology, Genetic Factors, Pathogenesis, Diagnosis, and Control Measures of Both Diseases.

Authors:  Cristina Acín; Rosa Bolea; Marta Monzón; Eva Monleón; Bernardino Moreno; Hicham Filali; Belén Marín; Diego Sola; Marina Betancor; Isabel M Guijarro; Mirta García; Antonia Vargas; Juan José Badiola
Journal:  Animals (Basel)       Date:  2021-03-04       Impact factor: 2.752

5.  PrPres in placental tissue following experimental transmission of atypical scrapie in ARR/ARR sheep is not infectious by Tg338 mouse bioassay.

Authors:  Robert B Piel; Valerie R McElliott; James B Stanton; Dongyue Zhuang; Sally A Madsen-Bouterse; Linda K Hamburg; Robert D Harrington; David A Schneider
Journal:  PLoS One       Date:  2022-01-21       Impact factor: 3.240

6.  Prediction of Genetic Resistance for Scrapie in Ungenotyped Sheep Using a Linear Animal Model.

Authors:  Mohammed Boareki; Flavio Schenkel; Delma Kennedy; Angela Cánovas
Journal:  Genes (Basel)       Date:  2021-09-17       Impact factor: 4.096
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.