David O Otuya1, Yogesh Verma1, Romain Luu1, Hamid Farrrokhi1, Guillermo J Tearney1,2,3. 1. Massachusetts General Hospital, Harvard Medical School and the Wellman Center for Photomedicine, Bos, United States. 2. Harvard-MIT Division of Health Sciences and Technology, Cambridge, Massachusetts, United States. 3. Harvard Medical School and Massachusetts General Hospital, Department of Pathology, Boston, Massachu, United States.
Abstract
SIGNIFICANCE: While spectral-domain optical coherence tomography (SD-OCT) is a preferred form of OCT imaging, sensitivity roll-off limits its applicability for certain biomedical imaging applications. AIM: The aim of this work is to extend the imaging range of conventional SD-OCT systems for imaging large luminal organs such as the gastrointestinal tract. APPROACH: We present an SD-OCT system operating at a center wavelength of 1300 nm that uses two delayed reference arms to reduce sensitivity roll-off and an optical switch and a fiber optic delay line to ensure that the interference spectra are acquired from the same sample time window. RESULT: The proposed system was used to image swine colon ex vivo and duodenum in vivo, demonstrating improved image quality due to a ∼14 dB increase in sensitivity at the edges of the ranging depth. CONCLUSION: The proposed system requires modest hardware implementation and is compatible with catheter-based endoscopic helical scanning with enhanced sensitivity for the samples at a distance of ∼6 mm from the zero delay point.
SIGNIFICANCE: While spectral-domain optical coherence tomography (SD-OCT) is a preferred form of OCT imaging, sensitivity roll-off limits its applicability for certain biomedical imaging applications. AIM: The aim of this work is to extend the imaging range of conventional SD-OCT systems for imaging large luminal organs such as the gastrointestinal tract. APPROACH: We present an SD-OCT system operating at a center wavelength of 1300 nm that uses two delayed reference arms to reduce sensitivity roll-off and an optical switch and a fiber optic delay line to ensure that the interference spectra are acquired from the same sample time window. RESULT: The proposed system was used to image swine colon ex vivo and duodenum in vivo, demonstrating improved image quality due to a ∼14 dB increase in sensitivity at the edges of the ranging depth. CONCLUSION: The proposed system requires modest hardware implementation and is compatible with catheter-based endoscopic helical scanning with enhanced sensitivity for the samples at a distance of ∼6 mm from the zero delay point.
Authors: Benjamin J Vakoc; Milen Shishko; Seok H Yun; Wang-Yuhl Oh; Melissa J Suter; Adrien E Desjardins; John A Evans; Norman S Nishioka; Guillermo J Tearney; Brett E Bouma Journal: Gastrointest Endosc Date: 2007-03-26 Impact factor: 9.427
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