Bijan Movahedian1, Mansour Rismanchian2, Hooman Navaei3, Saeid Tavanafar4, Soheil Koushaei5. 1. Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. 2. Department of Prosthodontics, Dental Implants Research Center, School of Dentistry, Isfahan University of Medical Sciences, Isfahan, Iran. 3. Department of Oral and Maxillofacial Surgery, School of Dentistry, Isfahan University of Medical Sciences, Esfahan, Iran. 4. Department of Oral and Maxillofacial Surgery, School of Dentistry, Shiraz University of Medical Sciences, Shiraz, Iran. s.tavanafar@gmail.com. 5. Department of Oral and Maxillofacial Surgery, School of Dentistry, Qazvin University of Medical Sciences, Qazvin, Iran.
Abstract
BACKGROUND: Nicotine can have detrimental effects on dental implant osseointegration. This study aimed to evaluate the influence of systemic L-arginine supplement on the osseointegration of dental implants in nicotine consumer dogs. METHODS: Twelve 1-year Labrador Retriever dogs had their right and left third and fourth mandibular premolars removed, and the sockets were left to heal for 6 months. Dogs were randomly divided into three groups (n = 16): group 1-0.2 mg/kg nicotine was injected twice daily; group 2-0.2 mg/kg nicotine was injected twice daily in addition to 200 mg/kg L-arginine capsules taken orally; and group 3-placebo. Forty-eight dental implants were inserted into the healed sockets of the dog's mandible and were assessed by implant stability quotient (ISQ) using resonance frequency analysis (RFA) during 4 weeks and insertion and removal torque value analysis. RESULTS: No implant failure occurred during the study period. The change in torque value between insertion and removal was similar in the placebo and nicotine+arginine consumer dogs (p = 0.276), which shows a positive effect of arginine supplementation in nicotine consumers. There was a significant difference in torque value change between nicotine+arginine vs. nicotine consumers (p = 0.049) and placebo vs. nicotine (p = 0.003). After 4 weeks, the placebo had the most significant improvement in torque value (47.0 ± 16.9), followed by nicotine+arginine (25.1 ± 37.8), and the worst torque value was for the nicotine group (- 5.7 ± 24.0) pound per inch. The results show that except in the first week, there are significant differences in ISQ between the groups in different periods. ISQ in all of the groups has reduced at first but then increased over time. At the time of implant placement, insertion torque was significantly higher in the nicotine consumer group than the nicotine+arginine consumer group and placebo group (p = 0.020). CONCLUSION: Arginine supplementation promotes bone healing and implant primary stability by improving dental implant osseointegration biomechanical characteristics.
BACKGROUND:Nicotine can have detrimental effects on dental implant osseointegration. This study aimed to evaluate the influence of systemic L-arginine supplement on the osseointegration of dental implants in nicotine consumer dogs. METHODS: Twelve 1-year Labrador Retriever dogs had their right and left third and fourth mandibular premolars removed, and the sockets were left to heal for 6 months. Dogs were randomly divided into three groups (n = 16): group 1-0.2 mg/kg nicotine was injected twice daily; group 2-0.2 mg/kg nicotine was injected twice daily in addition to 200 mg/kg L-arginine capsules taken orally; and group 3-placebo. Forty-eight dental implants were inserted into the healed sockets of the dog's mandible and were assessed by implant stability quotient (ISQ) using resonance frequency analysis (RFA) during 4 weeks and insertion and removal torque value analysis. RESULTS: No implant failure occurred during the study period. The change in torque value between insertion and removal was similar in the placebo and nicotine+arginine consumer dogs (p = 0.276), which shows a positive effect of arginine supplementation in nicotine consumers. There was a significant difference in torque value change between nicotine+arginine vs. nicotine consumers (p = 0.049) and placebo vs. nicotine (p = 0.003). After 4 weeks, the placebo had the most significant improvement in torque value (47.0 ± 16.9), followed by nicotine+arginine (25.1 ± 37.8), and the worst torque value was for the nicotine group (- 5.7 ± 24.0) pound per inch. The results show that except in the first week, there are significant differences in ISQ between the groups in different periods. ISQ in all of the groups has reduced at first but then increased over time. At the time of implant placement, insertion torque was significantly higher in the nicotine consumer group than the nicotine+arginine consumer group and placebo group (p = 0.020). CONCLUSION:Arginine supplementation promotes bone healing and implant primary stability by improving dental implant osseointegration biomechanical characteristics.
Authors: Adriano Piattelli; Luciano Artese; Enrico Penitente; Flavia Iaculli; Marco Degidi; Carlo Mangano; Jamil Awad Shibli; Paulo G Coelho; Vittoria Perrotti; Giovanna Iezzi Journal: J Biomed Mater Res B Appl Biomater Date: 2013-09-16 Impact factor: 3.368
Authors: Seiichi Yamano; Joel A Berley; Winston P Kuo; German O Gallucci; Hans-Peter Weber; Cortino Sukotjo Journal: Clin Oral Implants Res Date: 2010-12 Impact factor: 5.977
Authors: Guoyao Wu; Fuller W Bazer; Teresa A Davis; Sung Woo Kim; Peng Li; J Marc Rhoads; M Carey Satterfield; Stephen B Smith; Thomas E Spencer; Yulong Yin Journal: Amino Acids Date: 2008-11-23 Impact factor: 3.520