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Literature DB >> 3356968

Extracellular killing of Leishmania promastigotes and amastigotes by macrophage precursors derived from bone marrow cultures.

M Baccarini¹, S Hockertz, A F Kiderlen, M L Lohmann-Matthes.

Abstract

Flagellates of the genus Leishmania are obligate intracellular parasites of vertebrates including man. The microorganisms reside and multiply inside the phagolysosomes of cells of the mononuclear phagocyte lineage. We here report on the spontaneous leishmanicidal activity exerted extracellularly by immature cells of the mononuclear phagocyte lineage. Highly purified, bone marrow-derived macrophage precursor cells displayed a strong spontaneous leishmanicidal activity already at very low effector/target rations (3:1, 6:1). This leishmanicidal activity was effective against both promastigotes and amastigotes as targets. The cytotoxic effect was evident within 4 h and maximal after 12 h of effector-target organism cocultivation, as determined by a radiolabel-release assay. An intimate cell-cell contact seemed necessary for the parasites to be killed.

Entities: Disease Species

Mesh：

Year: 1988 PMID： 3356968 PMCID： PMC2188919 DOI： 10.1084/jem.167.4.1486

Source DB: PubMed Journal: J Exp Med ISSN： 0022-1007 Impact factor: 14.307

13 in total

1. Organ-associated macrophage precursor activity: isolation of candidacidal and tumoricidal effectors from the spleens of cyclophosphamide-treated mice.

Authors: M Baccarini; F Bistoni; M L Lohmann-Matthes
Journal: J Immunol Date: 1986-02-01 Impact factor: 5.422

2. Antibody-dependent cellular cytotoxicity against tumor cells. II. The promonocyte identified as effector cell.

Authors: W Domzig; M L Lohmann-Matthes
Journal: Eur J Immunol Date: 1979-04 Impact factor: 5.532

3. In vitro reactivity of natural killer (NK) cells against Cryptococcus neoformans.

Authors: J W Murphy; D O McDaniel
Journal: J Immunol Date: 1982-04 Impact factor: 5.422

4. Natural cell-mediated cytotoxicity against Trichomonas vaginalis in the mouse. I. Tissue, strain, age distribution, and some characteristics of the effector cells.

Authors: S Landolfo; M G Martinotti; P Martinetto; G Forni
Journal: J Immunol Date: 1980-02 Impact factor: 5.422

3. Cooperative effects of colony-stimulating factor 1 and recombinant interleukin 2 on proliferation and induction of cytotoxicity of macrophage precursors generated from mouse bone marrow cell cultures.

Authors: H Li; R Schwinzer; M Baccarini; M L Lohmann-Matthes
Journal: J Exp Med Date: 1989-03-01 Impact factor: 14.307

3 in total

Extracellular killing of Leishmania promastigotes and amastigotes by macrophage precursors derived from bone marrow cultures.

1. Organ-associated macrophage precursor activity: isolation of candidacidal and tumoricidal effectors from the spleens of cyclophosphamide-treated mice.

2. Antibody-dependent cellular cytotoxicity against tumor cells. II. The promonocyte identified as effector cell.

3. In vitro reactivity of natural killer (NK) cells against Cryptococcus neoformans.

4. Natural cell-mediated cytotoxicity against Trichomonas vaginalis in the mouse. I. Tissue, strain, age distribution, and some characteristics of the effector cells.

5. Promonocytes have the functional characteristics of natural killer cells.

6. Morphological characterization of a cell population responsible for natural killer activity.

7. Destruction of Trypanosoma cruzi by Natural killer cells.

8. Functional heterogeneity of murine macrophage precursor cells from spleen and bone marrow.

9. In vitro natural cell-mediated cytotoxicity against Candida albicans: macrophage precursors as effector cells.

10. Participation of natural killer cells in the recovery of mice from visceral leishmaniasis.

1. Cytokine activation of murine macrophages for in vitro killing of Entamoeba histolytica trophozoites.

2. Sex differences in host resistance to Mycobacterium marinum infection in mice.

3. Cooperative effects of colony-stimulating factor 1 and recombinant interleukin 2 on proliferation and induction of cytotoxicity of macrophage precursors generated from mouse bone marrow cell cultures.