Martin C Nwadiugwu1. 1. Faculty of Health and Sports, University of Stirling, Stirling, United Kingdom.
Abstract
Background: Diabetes is a long-term condition that can be treated and controlled but do not yet have a cure; it could be induced by inflammation and the goal of managing it is to prevent additional co-morbidities and reduce glycemic fluctuations. There is a need to examine inflammatory activities in diabetes-related angiopathies and explore interventions that could reduce the risk for future outcome or ameliorate its effects to provide insights for improved care and management strategies. Method: The study was conducted in Embase (1946-2020), Ovid Medline (1950-2020), and PubMed databases (1960-2020) using the PICO framework. Primary studies (randomized controlled trials) on type 2 diabetes mellitus and inflammatory activities in diabetes-related angiopathies were included. Terms for the review were retrieved from the Cochrane library and from PROSPERO using its MeSH thesaurus qualifiers. Nine articles out of 454 total hits met the eligibility criteria. The quality assessment for the selected study was done using the Center for Evidence-Based Medicine Critical Appraisal Sheet. Results: Data analysis showed that elevated CRP, TNF-α, and IL-6 were the most commonly found inflammatory indicator in diabetes-related angiopathies, while increased IL-10 and soluble RAGE was an indicator for better outcome. Use of drugs such as salsalate, pioglitazone, simvastatin, and fenofibrate but not glimepiride or benfotiamine reported a significant decrease in inflammatory events. Regular exercise and consumption of dietary supplements such as ginger, hesperidin which have anti-inflammatory properties, and those containing prebiotic fibers (e.g., raspberries) revealed a consistent significant (p < 0.05) reduction in inflammatory activities. Conclusion: Inflammatory activities are implicated in diabetes-related angiopathies; regular exercise, the intake of healthy dietary supplements, and medications with anti-inflammatory properties could result in improved protective risk outcome for diabetes patients by suppressing inflammatory activities and elevating anti-inflammatory events.
Background: Diabetes is a long-term condition that can be treated and controlled but do not yet have a cure; it could be induced by inflammation and the goal of managing it is to prevent additional co-morbidities and reduce glycemic fluctuations. There is a need to examine inflammatory activities in diabetes-related angiopathies and explore interventions that could reduce the risk for future outcome or ameliorate its effects to provide insights for improved care and management strategies. Method: The study was conducted in Embase (1946-2020), Ovid Medline (1950-2020), and PubMed databases (1960-2020) using the PICO framework. Primary studies (randomized controlled trials) on type 2 diabetes mellitus and inflammatory activities in diabetes-related angiopathies were included. Terms for the review were retrieved from the Cochrane library and from PROSPERO using its MeSH thesaurus qualifiers. Nine articles out of 454 total hits met the eligibility criteria. The quality assessment for the selected study was done using the Center for Evidence-Based Medicine Critical Appraisal Sheet. Results: Data analysis showed that elevated CRP, TNF-α, and IL-6 were the most commonly found inflammatory indicator in diabetes-related angiopathies, while increased IL-10 and soluble RAGE was an indicator for better outcome. Use of drugs such as salsalate, pioglitazone, simvastatin, and fenofibrate but not glimepiride or benfotiamine reported a significant decrease in inflammatory events. Regular exercise and consumption of dietary supplements such as ginger, hesperidin which have anti-inflammatory properties, and those containing prebiotic fibers (e.g., raspberries) revealed a consistent significant (p < 0.05) reduction in inflammatory activities. Conclusion: Inflammatory activities are implicated in diabetes-related angiopathies; regular exercise, the intake of healthy dietary supplements, and medications with anti-inflammatory properties could result in improved protective risk outcome for diabetespatients by suppressing inflammatory activities and elevating anti-inflammatory events.
Authors: Georgios K Chalikias; Dimitrios N Tziakas; Juan Carlos Kaski; Eleni I Hatzinikolaou; Dimitrios A Stakos; Ioannis K Tentes; Alexandros Kortsaris; Dimitrios I Hatseras Journal: Atherosclerosis Date: 2005-02-26 Impact factor: 5.162
Authors: Frank M Sacks; Michel P Hermans; Paola Fioretto; Paul Valensi; Timothy Davis; Edward Horton; Christoph Wanner; Khalid Al-Rubeaan; Ronnie Aronson; Isabella Barzon; Louise Bishop; Enzo Bonora; Pongamorn Bunnag; Lee-Ming Chuang; Chaicharn Deerochanawong; Ronald Goldenberg; Benjamin Harshfield; Cristina Hernández; Susan Herzlinger-Botein; Hiroshi Itoh; Weiping Jia; Yi-Der Jiang; Takashi Kadowaki; Nancy Laranjo; Lawrence Leiter; Takashi Miwa; Masato Odawara; Ken Ohashi; Atsushi Ohno; Changyu Pan; Jiemin Pan; Juan Pedro-Botet; Zeljko Reiner; Carlo Maria Rotella; Rafael Simo; Masami Tanaka; Eugenia Tedeschi-Reiner; David Twum-Barima; Giacomo Zoppini; Vincent J Carey Journal: Circulation Date: 2013-12-18 Impact factor: 29.690