Short-Term Effects of COVID-19-Related Deferral of Intravitreal Injection Visits.

PURPOSE: To determine secondary effects of the mandated COVID-19 pandemic closure period for elective treatment on non-elective, injection-based retina care and outcomes. PATIENTS AND METHODS: In this cross-sectional, retrospective analysis of a single-provider outpatient clinic across multiple satellites, consecutive patients returning for intravitreal injections (IVIs) of anti-vascular endothelial growth factor or corticosteroids were identified as "delayed" or "undelayed" during a six-week study interval during the COVID-19 pandemic that closely following a mandated period of prohibited elective encounters. A "delayed" encounter was defined as having a follow-up interval exceeding 33% of the recommended cycle. Patients seen for IVIs during the corresponding six-week interval a year previously were identified for study as pre-COVID-19 controls. Main outcome measures included best-corrected visual acuity (BCVA) and optical coherence tomography (OCT) assessment based on findings of intraretinal or subretinal fluid consistent with new or recurrent neovascular events.
RESULTS: The study included 183 eyes of 144 patients who underwent IVI-based care from June 18, 2020, through August 7, 2020, compared to 193 eyes of 154 patients injected during the corresponding interval 1 year before. There were 62 eyes of 46 patients seen in the study period later than scheduled (among 144 patients of 183 eyes in total), which represented a larger proportion of delayed patients compared to the previous year (31.9% vs. 14.9%, p<0.0005). Considering the patterns from the control group, the attributed delay due to COVID-19 was 15.0% of patients. The delayed return eyes had a greater decline in BCVA (3 letters), higher rates of worsened OCT results (48%), and prompted reduction in previously prescribed injection intervals (p<0.02).
CONCLUSION: The unintended consequence of delayed care of patients on established care regimens should be anticipated, and mitigate strategies considered if similar restrictions are mandated in the future.

Plain Language Summary

The purpose of this investigation was to determine the short-term impact of COVID-19 pandemic shutdown mandates on patients returning for previously established injection-based retinal treatment regimens.

Consecutive patients returning for intravitreal injections (IVIs) of anti-vascular endothelial growth factor or corticosteroids during a six-week study interval during the COVID-19 pandemic that closely following a mandated period of prohibited elective encounters. This included IVI patients returning later than scheduled and returning as scheduled. Patients seen for IVI from the corresponding interval a year previously were identified for study as pre-COVID-19 controls.

The results of this single-provider, cross-sectional study demonstrated more frequent delayed appointments, resulting in higher rates of declined visual acuity, worsened OCT results, and reduced prescribed injection intervals, when compared to those who continued their scheduled intervals.

Many patients suffering from retinal vascular diseases were adversely impacted by a delay in their regular intravitreal injections as a result of the initial pandemic shutdown. This unintended consequence should be anticipated with attempts to mitigate if similar restrictions are mandated in the future or in considering any external disruption of care.

Introduction

COVID-19 was first identified as a public health hazard in late December 20191 and was accorded pandemic status on March 11, 2020.2 The national task force recommended, as part of its response to mitigate spread, a temporary nationwide halt on non-urgent procedures in the United States.2,3 Consequently, an executive order by the Florida governor authorized only urgent encounters beginning on March 17, 2020 and ending on May 11, 2020.4

The American Academy of Ophthalmology and the American Society of Retinal Specialists formulated guidelines defining urgent conditions to offer guidance.5,6 Vision-threatening conditions were authorized for visits including intravitreal injections (IVIs) for various prevalent retinal vascular conditions.6 Despite administrative efforts to maintain urgent appointments, some patients thought the clinic was completely closed or elected to defer their appointments due to personal concerns.

We studied the characteristics and results of patients undergoing IVIs who re-established care during a six-week interval shortly following the restricted period.

Methods

All studies were conducted after approval of Human Subjects Committee of the University of Miami which granted a waiver of study consent due to the low risk to the patient and the retrospective nature of the study, and in accordance with the Declarations of Helsinki. We reviewed a six-week study interval (from 6/18/2020 to 8/7/2020), a month after rescission which was chosen to allow for a transition to “new normal” operations. Inclusion criteria included adults ages 18 and over who had been engaged in active IVI treatment (defined as having had at least 3 prior visits) for a diagnosis of macular edema or neovascular complications. Exclusions included repeated injections within the study interval and eyes that had not been seen 3 times or within the previous 12 months.

One retina specialist saw all patients during the study interval across four practice sites using the same electronic record. Standard protocols were enacted to maximize patient safety, including universal masks, social distancing through restrictions of visitors, use of plastic barriers at desks, and compulsive hand-washing. The previous three visits were reviewed to identify a delayed encounter which was defined as when the delay exceeded 33% of the previously scheduled follow-up cycle (eg, returning at >8 weeks instead of 6 weeks). A pre-COVID-19 control group was assembled from encounters during the corresponding interval in 2019. The treating physician typically (but not using a standard protocol) asked the patient why their visit was delayed, taking care not to compound their anxieties of missing the appointment.

Clinical information analyzed is listed in . Outcome measures included BCVA (logMAR) change, OCT status (better, stable, worse), switch of intravitreal agent, and change in previously established follow-up interval. The OCT was judged to be worse when there was an increase in subretinal or intraretinal fluid; all changes were not subtle.

Statistical analyses were performed using the SPSS 26.0 (SPSS Inc, Chicago, IL) software package. Analyses were performed using Pearson χ2 analysis, Fisher exact test, and t-test, when appropriate. A p-value of 0.05 or lower was considered statistically significant.

Results

The number of IVIs in the 2020 study interval was 9.9% (219 vs. 243) lower than for the corresponding 2019 pre-COVID-19 control group (Table 1). After exclusions, 183 eyes of 144 patients were identified during the study interval (study group), and 193 eyes of 154 patients during the corresponding pre-COVID-19 interval (control group).

Table 1

Detailed Counts of Included and Excluded Intravitreal Injections (IVI) and Study Patients of the 2019 and 2020 Cohorts

Study Period	Patients	Eyes
2020 Total	175	219
Excluded	31	36
Second encounter	16	20
>12 months since last visit	6	6
<3 injection visits	9	10
Study Group 2020	144	183
Delayed	46	62
Not Delayed	98	121
2019 Total	200	243
Excluded	46	50
Second encounter	16	19
>12 months since last visit	17	17
<3 injection visits	13	14
Control Group 2019	154	193
Delayed	23	26
Not Delayed	131	167

The study group included 62/183 (33.9%) eyes of 46/144 (31.9%) patients whose visit was delayed and 121/183 (66.1%) eyes of 98/144 (68.1%) patients whose visit was not delayed. In contrast, in the 2019 control group 26/193 (13.5%) eyes of 23/154 (14.9%) patients had been delayed and 167/193 (86.5%) eyes of 131/154 (85.1%) patients were not delayed (both p<0.0005). Thus, the number of delayed visits attributable to the COVID-19 closure was 20.4% of eyes and 15.0% of patients.

The mean delay in the study group was 3.08 (SD 5.70) weeks, compared to 1.50 (SD 7.29) weeks in the 2019 cohort (p=0.021). Delayed encounters in the study group were attributable to patient concern for COVID-19 in 20/46 (43.5%) patients, other personal reasons in 10 (6.6%) patients, unspecified in 15/46 (32.6%) patients, and illness during the closure period in 1/46 (2.2%). One patient each in the delayed and not delayed group indicated having had COVID-19 infection.

The delayed subgroup had a larger proportion with at least a 0.05 logMAR (3 letters) loss in BCVA, poorer OCT results (50%), and more often was switched to different IVI agents compared to those not delayed (p<0.03) (Table 2). There were no statistically significant factors across the subgroups associated with worsening at re-presentation. However, eyes with wAMD were less frequently delayed compared to pseudophakic cystoid macular edema (5/6, 83.3%) and diabetic macular edema (21/45, 46.7%) (p=0.009) ().

Table 2

Outcome Measures for Delayed and Not Delayed Groups

	Delayed n (%N), N=62	Not Delayed n (%N), N=121	p-valueb
Visual Acuity Change (ΔlogMAR)	–	–	0.006*
≤0.05 (Snellen equivalent, <3 letter loss, or gain)	30 (48.4)	84 (69.4)	–
>0.05 (Snellen equivalent, >3 letter loss)	32 (51.6)	37 (30.6)
Visual Acuity (Snellen) at Study Visit	–	–	0.322*
≥20/40	15 (24.2)	42 (34.7)	–
20/50-20/200	38 (61.3)	66 (54.5)	–
<20/200	9 (14.5)	13 (10.7)	–
Optical Coherence Tomography Status	–	–	<0.001*
Better	6 (9.7)	31 (25.6)	–
Stable	26 (38.8)	78 (64.5)	–
Worse	30 (48.4)	12 (9.9)	–
Change in Intravitreal Agent	4 (6.5)	2 (1.7)	0.084*
Recommended Follow-Up Interval, Mean (SD)	–	–	–
Difference in follow-up interval (weeks)	−1.94 (18.07)	−0.08 (2.86)	0.011a

Notes: *Pearson χ2 analysis, Fisher exact test; aPaired Student’s t-test; bA bolded p-value indicates that it has reached the authors’ standards for statistical significance (p<0.05).

Abbreviations: SD, standard deviation.

Discussion

This retrospective study showed 32% of patients returning for established IVIs were delayed in their follow-up during a six-week study interval shortly following the restricted interval; half of the delays were attributable to COVID-19 concerns. The magnitude of the disruption might be even larger, since nearly 10% fewer incident IVI patients were seen compared to a corresponding control group. Moreover, the consequences of delay included worse BCVA loss and more frequent worsening in the OCT features. This is one of the first studies to show worse visual acuities and OCT findings in eyes whose IVIs were delayed due the COVID-19 pandemic and is unique in that it surveyed results of those re-presenting rather than just those not presenting.

Delayed IVI care is not unique to the constraints of the pandemic closure and has been shown by others to be associated with inferior outcomes in retinal vascular diseases.7–9 Relatedly, we acknowledge that alterations in the management plan (changing agents, shortening of subsequent follow-up intervals) were subjective, based on the recommendations and potential biases of the treating physician.

Obeid et al studied 9007 wet AMD patients in which 22% were lost to follow up for over 12 months after IVI. Risk factors for failure to return included lack of VA improvement, female gender, non-Caucasian, distance residing from the office, and unilateral versus bilateral treatment.10 Gao et al reported 25% of 3400 patients with retinal vein occlusion with macular edema were lost to follow-up over 12 months. Risk factors included non-Caucasian, <65 years, and poorer baseline vision.11 The current study did not demonstrate these risk factors, but was substantially smaller and was conducted under a different setting.

Lange et al estimated that by May 2020, nearly 41% of adults had delayed medical care due to fear of the pandemic, corresponding to marked reductions in both routine and emergency encounters for life-threatening conditions.12 Recent studies show that the 2020 pandemic closure resulted in a 53–75% reduction in IVIs when compared to 2019.4,13,14 Our study demonstrates a relatively lower, but significant, 10% overall decrease in IVI volume in 2020 after the severest of restrictions were rescinded compared to the same period in 2019, with over 2.5 times as many delayed intravitreal injection treatment encounters. At least 42% of these delayed IVIs were directly related to pandemic-related constraints.

Reports from other countries have suggested a similar experience as is related in the current manuscript. Saleh et al reported that intravitreal injections were safely delivered, without any know Covid-19 case transmission in a tertiary care clinic in Jordan, but clinical volumes were diminished due to patient fears regarding contracting the virus.15 Moreover, those who did seek care had poorer presenting visual acuity. Two studies from Milan, Italy also documented decreased clinical (up to 71%) and injection (54–58%) volumes.13,16 There was a higher rate of submacular hemorrhage among wAMD patient reported16 and a higher rate of absence among elderly and wAMD compared to other diagnostic categories.13

Diabetics and the elderly wARMD represent groups that are at higher risk of complications from COVID-19 infection. Understandably, those patients frequently chose not to risk coming to their appointments. A dependence on travel arrangements to appointments, the need to quarantine for those in assisted living facilities, inaccurate information regarding their healthcare appointments, and illness were also likely was also additional factors in reduced compliance with IVI-based follow up during the COVID-19 pandemic period.

The current study captured cases that re-presented after a delay, rather than ascertaining the cohort that did not present as previously scheduled. The retrospective study design did not permit us to collect the reason for the delayed return in a standardized fashion.

In conclusion, the potentially deleterious effects of the pandemic closure period require careful consideration if future healthcare constraints are imposed. Clear messaging to define and to distinguish urgent and non-urgent categories of medical disease is essential. The degree of recovery after reestablishing care merits further investigation.