| Literature DB >> 33568675 |
Adam B Weiner1, Thiago Vidotto2, Yang Liu3, Adrianna A Mendes2, Daniela C Salles2, Farzana A Faisal4, Sanjana Murali2, Matthew McFarlane5, Eddie L Imada6, Xin Zhao3, Ziwen Li3, Elai Davicioni3, Luigi Marchionni6, Arul M Chinnaiyan7, Stephen J Freedland8,9, Daniel E Spratt5, Jennifer D Wu1,10, Tamara L Lotan2, Edward M Schaeffer11.
Abstract
Black men die more often of prostate cancer yet, interestingly, may derive greater survival benefits from immune-based treatment with sipuleucel-T. Since no signatures of immune-responsiveness exist for prostate cancer, we explored race-based immune-profiles to identify vulnerabilities. Here we show in multiple independent cohorts comprised of over 1,300 patient samples annotated with either self-identified race or genetic ancestry, prostate tumors from Black men or men of African ancestry have increases in plasma cell infiltrate and augmented markers of NK cell activity and IgG expression. These findings are associated with improved recurrence-free survival following surgery and nominate plasma cells as drivers of prostate cancer immune-responsiveness.Entities:
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Year: 2021 PMID： 33568675 PMCID： PMC7876147 DOI： 10.1038/s41467-021-21245-w
Source DB: PubMed Journal: Nat Commun ISSN： 2041-1723 Impact factor: 17.694