Cristiana Cipriani1, Salvatore Minisola1, John P Bilezikian2, Davide Diacinti3,4, Luciano Colangelo1,3, Valentina Piazzolla1, Maurizio Angelozzi1, Luciano Nieddu5, Jessica Pepe1, Daniele Diacinti6. 1. Department of Clinical, Internal, Anesthesiological and Cardiovascular Sciences, Sapienza University of Rome, Viale del Policlinico, Rome, Italy. 2. Division of Endocrinology, Vagelos College of Physicians and Surgeons, Columbia University, New York, NY, USA. 3. Department of Oral and Maxillo-Facial Sciences, Sapienza University of Rome, Italy. 4. Department of Diagnostic and Molecular Imaging, Radiology and Radiotherapy, University Tor Vergata, Rome, Italy. 5. Faculty of Economics, UNINT University, Via Cristoforo Colombo, Rome, Italy. 6. Department of Radiological Sciences, Oncology and Pathology, Sapienza University of Rome, Viale Regina Elena, Rome, Italy.
Abstract
CONTEXT: Hypoparathyroidism is a rare endocrine disorder whose skeletal features include suppression of bone turnover and greater volume and width of the trabecular compartment. Few and inconsistent data are available on the prevalence of vertebral fractures (VF). OBJECTIVE: To evaluate the prevalence of VF assessed by vertebral fracture assessment (VFA) in postmenopausal women with chronic postsurgical hypoparathyroidism. DESIGN: Cross-sectional study. SETTING: Ambulatory referral center. PATIENTS OR OTHER PARTICIPANTS: Fifty postmenopausal women (mean age 65.4 ± 9 years) with chronic postsurgical hypoparathyroidism and 40 age-matched healthy postmenopausal women (mean age 64.2 ± 8.6). MAIN OUTCOME MEASURES: Lumbar spine, femoral neck, and total hip bone mineral density were measured by dual X-ray absorptiometry (Hologic Inc., USA) in all subjects. Site-matched spine trabecular bone score was calculated by TBS iNsight (Medimaps, Switzerland). Assessment of VF was made by VFA (iDXA, Lunar GE, USA) using the semiquantitative method and the algorithm-based qualitative assessment. RESULTS: All-site BMD values were higher in the hypoparathyroid vs the control group. By VFA, we observed a 16% prevalence of VF in hypoparathyroid women vs 7.5% in control subjects. Among those with hypoparathyroidism who fractured, 5 (62.5%) had grade 1 wedge, 2 (25%) had grade 2 wedge, and 1 (12.5%) had grade 2 wedge and grade 2 biconcave VF. In the hypoparathyroid group, 57% with VFs and 32% without VFs had symptoms of hypoparathyroidism. CONCLUSION: We demonstrate for the first time that in postmenopausal women with chronic postsurgical hypoparathyroidism, VFs are demonstrable by VFA despite normal BMD.
CONTEXT: Hypoparathyroidism is a rare endocrine disorder whose skeletal features include suppression of bone turnover and greater volume and width of the trabecular compartment. Few and inconsistent data are available on the prevalence of vertebral fractures (VF). OBJECTIVE: To evaluate the prevalence of VF assessed by vertebral fracture assessment (VFA) in postmenopausal women with chronic postsurgical hypoparathyroidism. DESIGN: Cross-sectional study. SETTING: Ambulatory referral center. PATIENTS OR OTHER PARTICIPANTS: Fifty postmenopausal women (mean age 65.4 ± 9 years) with chronic postsurgical hypoparathyroidism and 40 age-matched healthy postmenopausal women (mean age 64.2 ± 8.6). MAIN OUTCOME MEASURES: Lumbar spine, femoral neck, and total hip bone mineral density were measured by dual X-ray absorptiometry (Hologic Inc., USA) in all subjects. Site-matched spine trabecular bone score was calculated by TBS iNsight (Medimaps, Switzerland). Assessment of VF was made by VFA (iDXA, Lunar GE, USA) using the semiquantitative method and the algorithm-based qualitative assessment. RESULTS: All-site BMD values were higher in the hypoparathyroid vs the control group. By VFA, we observed a 16% prevalence of VF in hypoparathyroid women vs 7.5% in control subjects. Among those with hypoparathyroidism who fractured, 5 (62.5%) had grade 1 wedge, 2 (25%) had grade 2 wedge, and 1 (12.5%) had grade 2 wedge and grade 2 biconcave VF. In the hypoparathyroid group, 57% with VFs and 32% without VFs had symptoms of hypoparathyroidism. CONCLUSION: We demonstrate for the first time that in postmenopausal women with chronic postsurgical hypoparathyroidism, VFs are demonstrable by VFA despite normal BMD.
Authors: John T Schousboe; Lisa M Lix; Suzanne N Morin; Sheldon Derkatch; Mark Bryanton; Mashael Alhrbi; William D Leslie Journal: J Bone Miner Res Date: 2019-09-10 Impact factor: 6.741
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Authors: Harold N Rosen; Tamara J Vokes; Alan O Malabanan; Chad L Deal; Jimmy D Alele; Thomas P Olenginski; John T Schousboe Journal: J Clin Densitom Date: 2013-09-22 Impact factor: 2.617
Authors: Cristiana Cipriani; Jessica Pepe; Barbara C Silva; Mishaela R Rubin; Natalie E Cusano; Donald J McMahon; Luciano Nieddu; Maurizio Angelozzi; Federica Biamonte; Daniele Diacinti; Didier Hans; Salvatore Minisola; John P Bilezikian Journal: J Bone Miner Res Date: 2018-08-08 Impact factor: 6.741
Authors: N C Harvey; C C Glüer; N Binkley; E V McCloskey; M-L Brandi; C Cooper; D Kendler; O Lamy; A Laslop; B M Camargos; J-Y Reginster; R Rizzoli; J A Kanis Journal: Bone Date: 2015-05-16 Impact factor: 4.398