| Literature DB >> 33565352 |
Xin-Yue Suo1, Meng-Jiao Shi1, Jun Dang2, Hui-Lan Yue2, Yan-Duo Tao2, Bo Zhen1, Jia-Jia Wang1, Xue Wang1, Hao-Ran Sun1, Hua Sun1, Gui-Fen Qiang1, Teng-Fei Ji1,2, Bo Liu3.
Abstract
Polycyclic polyprenylated acylphloroglucinols (PPAPs) were mainly obtained from the plants of Hypericum genus of Guttiferae family, and possessed intriguing chemical structures and appealing biological activities. Two new PPAPs derivatives, hyperacmosin C (1) and hyperacmosin D (2) were isolated from H. acmosepalum. Their structures were established by NMR, HREIMS, and experimental electronic circular dichroism spectra. Besides, compound 1 showed significant hepatoprotective activity at 10 µM against paracetamol-induced HepG2 cell damage and compound 2 could moderately increase the relative glucose consumption.Entities:
Keywords: ECD; Hypericum acmosepalum; PPAPs; hepatoprotective activity; relative glucose consumption
Year: 2021 PMID： 33565352 DOI： 10.1080/10286020.2021.1880395
Source DB: PubMed Journal: J Asian Nat Prod Res ISSN： 1028-6020 Impact factor: 1.569