Yasumori Sobue1,2, Toshihisa Kojima1, Hiromu Ito3, Keiichiro Nishida4, Isao Matsushita5, Yuko Kaneko6, Mitsumasa Kishimoto7, Masataka Kohno8, Takahiko Sugihara9, Yohei Seto10, Eiichi Tanaka11, Takeo Nakayama12, Shintaro Hirata13, Atsuko Murashima14, Akio Morinobu15, Masaaki Mori9, Masayo Kojima16, Yutaka Kawahito8, Masayoshi Harigai11. 1. Department of Orthopedic Surgery, Nagoya University Graduate School of Medicine, Nagoya, Japan. 2. Department of Orthopedic Surgery, Japanese Red Cross Nagoya Daiichi Hospital, Nagoya, Japan. 3. Department of Advanced Medicine for Rheumatic Diseases and Orthopedic Surgery, Kyoto University Graduate School of Medicine, Kyoto, Japan. 4. Department of Orthopaedic Surgery, Okayama University Graduate School of Medicine, Density and Pharmaceutical Sciences, Okayama, Japan. 5. Department of Rehabilitation Medicine, Kanazawa Medical University, Uchinada, Japan. 6. Department of Internal Medicine, Division of Rheumatology, Keio University School of Medicine, Tokyo, Japan. 7. Department of Nephrology and Rheumatology, Kyorin University School of Medicine, Tokyo, Japan. 8. Inflammation and Immunology, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan. 9. Department of Lifetime Clinical Immunology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, Tokyo, Japan. 10. Department of Rheumatology, Yachiyo Medical Center, Tokyo Women's Medical University, Chiba, Japan. 11. Department of Rheumatology, Tokyo Women's Medical University School of Medicine, Tokyo, Japan. 12. Department of Health Informatics, Kyoto University School of Public Health, Kyoto, Japan. 13. Department of Clinical Immunology and Rheumatology, Hiroshima University Hospital, Hiroshima, Japan. 14. Center for Maternal-Fetal, Neonatal and Reproductive Medicine/Japan Drug Information Institute in Pregnancy, National Center for Child Health and Development, Tokyo, Japan. 15. Department of Rheumatology and Clinical Immunology, Kobe University Graduate School of Medicine, Kobe, Japan. 16. Center for Gerontology and Social Science, National Center for Geriatrics and Gerontology, Obu, Japan.
Abstract
OBJECTIVES: This study aimed to evaluate the impact of exercise therapy on patient-reported outcomes (PROs) in rheumatoid arthritis (RA) as part of the process of updating the 2020 Japanese guidelines for the management of RA according to the Grading of Recommendations, Assessment, Development, and Evaluation system. METHODS: We searched PubMed, Japana Centra Revuo Medicina Web, and the Cochrane Library (from 2009 to 2018) to identify articles that evaluated PROs of exercise therapy and RA disease activity. RESULTS: A total of 662 articles were identified, including nine RCTs, and meta-analyses were performed on six RCTs on systemic exercise therapy and three RCTs on upper extremity exercise therapy. Analyzed exercise therapies were diverse, differing in target population, intervention method, and duration. Significant improvements were observed in the Health Assessment Questionnaire Disability Index (mean difference -0.35, 95% confidence interval (CI): -0.60 to -0.10), pain (standardized mean difference -2.04, 95% CI: -3.77 to -0.32), and SF-36. For upper extremity exercise therapy, significant improvements in PROs (Disabilities of the Arm, Shoulder, and Hand Questionnaire, Michigan Hand Outcome Questionnaire) were observed. CONCLUSION: Exercise therapy in RA treatment improves patient subjective assessment of pain, physical function, and quality of life.
OBJECTIVES: This study aimed to evaluate the impact of exercise therapy on patient-reported outcomes (PROs) in rheumatoid arthritis (RA) as part of the process of updating the 2020 Japanese guidelines for the management of RA according to the Grading of Recommendations, Assessment, Development, and Evaluation system. METHODS: We searched PubMed, Japana Centra Revuo Medicina Web, and the Cochrane Library (from 2009 to 2018) to identify articles that evaluated PROs of exercise therapy and RA disease activity. RESULTS: A total of 662 articles were identified, including nine RCTs, and meta-analyses were performed on six RCTs on systemic exercise therapy and three RCTs on upper extremity exercise therapy. Analyzed exercise therapies were diverse, differing in target population, intervention method, and duration. Significant improvements were observed in the Health Assessment Questionnaire Disability Index (mean difference -0.35, 95% confidence interval (CI): -0.60 to -0.10), pain (standardized mean difference -2.04, 95% CI: -3.77 to -0.32), and SF-36. For upper extremity exercise therapy, significant improvements in PROs (Disabilities of the Arm, Shoulder, and Hand Questionnaire, Michigan Hand Outcome Questionnaire) were observed. CONCLUSION: Exercise therapy in RA treatment improves patient subjective assessment of pain, physical function, and quality of life.
Authors: Pablo Rodríguez Sánchez-Laulhé; Luis Gabriel Luque-Romero; Francisco José Barrero-García; Ángela Biscarri-Carbonero; Jesús Blanquero; Alejandro Suero-Pineda; Alberto Marcos Heredia-Rizo Journal: JMIR Mhealth Uhealth Date: 2022-04-07 Impact factor: 4.947