Chia-Wen Lu1,2, Chih-Hsien Wang1,3, Yu-Li Lin1,3, Chiu-Huang Kuo1,4, Yu-Hsien Lai1,3, Bang-Gee Hsu1,2,3, Jen-Pi Tsai3,5. 1. Division of Nephrology, Hualien Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Hualien, Taiwan. 2. Institute of Medical Sciences, Tzu Chi University, Hualien, Taiwan. 3. School of Medicine, Tzu Chi University, Hualien, Taiwan. 4. School of Post-Baccalaureate Chinese Medicine, Tzu Chi University, Hualien, Taiwan. 5. Division of Nephrology, Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical Foundation, Chiayi, Taiwan.
Abstract
BACKGROUND: Irisin is a circulating hormone-like myokine that plays an important role in bone metabolism. We performed a cross-sectional study to investigate whether serum irisin levels correlated with bone mineral density (BMD) in patients on maintenance hemodialysis (MHD). METHODS: Blood samples were obtained from 80 patients on MHD, and serum irisin concentrations were determined using a commercially available enzyme-linked immunosorbent assay. BMD was measured by dual-energy X-ray absorptiometry of the L2-L4 vertebrae. RESULTS: In the study cohort, 10 (12.5%) and 19 (23.8%) patients had osteoporosis and osteopenia, respectively, and 51 (63.75%) patients had normal BMD. Lumbar T-score was negatively associated with body height (P=0.010), body weight (P=0.002), body mass index (BMI, P=0.010), and serum irisin (P < 0.001) and was positively associated with advanced age (P=0.031), female sex (P=0.001), alkaline phosphatase (ALP, P=0.010), urea reduction rate (P=0.018), and fractional clearance index for urea (P=0.020). Multivariable forward stepwise linear regression analysis revealed that high serum logarithmically transformed irisin (log-irisin, β = 0.450, adjusted R 2 change = 0.258; P < 0.001), female sex (β = -0.353, adjusted R 2 change = 0.134; P < 0.001), and serum ALP level (β = -0.176, adjusted R 2 change = 0.022; P=0.049) were significantly and independently associated with lumbar BMD in patients on MHD. CONCLUSIONS: In addition to female sex and serum ALP level, serum irisin level was positively associated with lumbar BMD in patients on MHD.
BACKGROUND: Irisin is a circulating hormone-like myokine that plays an important role in bone metabolism. We performed a cross-sectional study to investigate whether serum irisin levels correlated with bone mineral density (BMD) in patients on maintenance hemodialysis (MHD). METHODS: Blood samples were obtained from 80 patients on MHD, and serum irisin concentrations were determined using a commercially available enzyme-linked immunosorbent assay. BMD was measured by dual-energy X-ray absorptiometry of the L2-L4 vertebrae. RESULTS: In the study cohort, 10 (12.5%) and 19 (23.8%) patients had osteoporosis and osteopenia, respectively, and 51 (63.75%) patients had normal BMD. Lumbar T-score was negatively associated with body height (P=0.010), body weight (P=0.002), body mass index (BMI, P=0.010), and serum irisin (P < 0.001) and was positively associated with advanced age (P=0.031), female sex (P=0.001), alkaline phosphatase (ALP, P=0.010), urea reduction rate (P=0.018), and fractional clearance index for urea (P=0.020). Multivariable forward stepwise linear regression analysis revealed that high serum logarithmically transformed irisin (log-irisin, β = 0.450, adjusted R 2 change = 0.258; P < 0.001), female sex (β = -0.353, adjusted R 2 change = 0.134; P < 0.001), and serum ALP level (β = -0.176, adjusted R 2 change = 0.022; P=0.049) were significantly and independently associated with lumbar BMD in patients on MHD. CONCLUSIONS: In addition to female sex and serum ALP level, serum irisin level was positively associated with lumbar BMD in patients on MHD.
Authors: Sarah L West; Charmaine E Lok; Lisa Langsetmo; Angela M Cheung; Eva Szabo; Dawn Pearce; Maria Fusaro; Ron Wald; Jordan Weinstein; Sophie A Jamal Journal: J Bone Miner Res Date: 2015-05 Impact factor: 6.741
Authors: G Colaianni; A Notarnicola; S Colucci; M Grano; L Sanesi; G Brunetti; L Lippo; M Celi; L Moretti; V Pesce; G Vicenti; B Moretti Journal: J Biol Regul Homeost Agents Date: 2017 Oct-Dec, Impact factor: 1.711