Fotios Dimitriadis1, Evangelos N Symeonidis1, Panagiota Tsounapi2, Aris Kaltsas3, Georgios Hatzichristodoulou4, Ioannis Sokolakis4, Athanasios Zachariou3, Atsushi Takenaka2, Nikolaos Sofikitis3.
Abstract
BACKGROUND &
OBJECTIVE: Significant advances in the field of male infertility have been witnessed during the last years. Given the well-known detrimental effects of reactive oxygen species (ROS), the administration of antioxidants has emerged as a promising solution for oxidative stress (OS)-induced male infertility. Nevertheless, this perception seems largely oversimplified, and the existing literature fails to recognize a notable superiority of the excessive use of these widely available nutritional compounds. Taking into consideration that several trials have shed light on the so-called "antioxidant paradox" phenomenon, we recognize that over-the-counter consumption of such supplements might be harmful.
METHOD: The relevant studies indexed in PubMed, Google Scholar and Scopus databases, published until September 2019 were identified and reported.
CONCLUSION: In this setting, we acknowledge that there is an eminent need for more elaborate studies in the future which will efficiently elucidate the risks and benefits of antioxidants on semen parameters and their impact on fertility potential. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
BACKGROUND &
OBJECTIVE: Significant advances in the field of male infertility have been witnessed during the last years. Given the well-known detrimental effects of reactive oxygen species (ROS), the administration of antioxidants has emerged as a promising solution for oxidative stress (OS)-induced male infertility. Nevertheless, this perception seems largely oversimplified, and the existing literature fails to recognize a notable superiority of the excessive use of these widely available nutritional compounds. Taking into consideration that several trials have shed light on the so-called "antioxidant paradox" phenomenon, we recognize that over-the-counter consumption of such supplements might be harmful.
METHOD: The relevant studies indexed in PubMed, Google Scholar and Scopus databases, published until September 2019 were identified and reported.
CONCLUSION: In this setting, we acknowledge that there is an eminent need for more elaborate studies in the future which will efficiently elucidate the risks and benefits of antioxidants on semen parameters and their impact on fertility potential. Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.
Entities:
Keywords:
antioxidant paradox; antioxidants; male infertility; oxidative stress.; reactive oxygen species; reductive stress
Year: 2021
PMID： 33563149 DOI： 10.2174/1381612827666210204160248
Source DB: PubMed Journal: Curr Pharm Des ISSN： 1381-6128 Impact factor: 3.116