| Literature DB >> 33562648 |
Hee Jae Shin1,2, Cao Van Anh1,2, Duk-Yeon Cho3, Dong-Kug Choi3, Jong Soon Kang4, Phan Thi Hoai Trinh5, Byeoung-Kyu Choi1, Hwa-Sun Lee1.
Abstract
Three new polyene compounds, talacyanols A-C (1-3), along with two known compounds, ramulosin (4) and eurothiocin A (5), were isolated from the marine fungus Talaromyces cyanescens derived from a seaweed Caulerpa sp. Structures of 1-5 were established by one-dimensional and two-dimensional (1D/2D) NMR, HR-ESIMS, and the modified Mosher's methods, as well as comparison with previously reported literature data. All the compounds (1-5) were tested for their in vitro cytotoxic and anti-neuroinflammatory activities. Among them, 1 showed moderate cytotoxic activity against a panel of cancer cell lines (HCT-15, NUGC-3, NCI-H23, ACHN, PC-3, and MDA-MB-231) with GI50 values ranging from 44.4 to 91.6 μM, whereas compounds 2 and 5 exhibited anti-neuroinflammatory effect without cytotoxicity against all the tested cell lines.Entities:
Keywords: Talaromyces cyanescens; anti-neuroinflammatory; cytotoxicity; marine-derived fungus; polyenes
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Year: 2021 PMID： 33562648 PMCID： PMC7915668 DOI： 10.3390/molecules26040836
Source DB: PubMed Journal: Molecules ISSN： 1420-3049 Impact factor: 4.411