Reza Fadaei1, Roya Safari-Faramani1, Hossein Hosseini2, Mehdi Koushki3, Reza Ahmadi4, Masoumeh Rostampour1, Habibolah Khazaie5. 1. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. 2. Department of Biochemistry, Faculty of Medicine, Tehran University of Medical Sciences, Tehran, Iran. 3. Department of Biochemistry, School of Medicine, Zanjan University of Medical Sciences, Zanjan, Iran. 4. Clinical Biochemistry Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran. 5. Sleep Disorders Research Center, Kermanshah University of Medical Sciences, Kermanshah, Iran. hakhazaie@gmail.com.
Abstract
PURPOSE: Obstructive sleep apnea (OSA) is a prevalent sleep disorder associated with increased risk of cardiovascular disease. Several studies have demonstrated elevated oxidative stress in patients with OSA. This oxidative stress is a direct inducer of lipid peroxidation. Malondialdehyde (MDA), a robust marker of lipid peroxidation, has been evaluated in patients with OSA but results have been inconsistent. The present systematic review and meta-analysis was performed to quantify the circulating levels of MDA in patients with OSA compared to controls. METHODS: Search was performed in data bases of PubMed, Scopus, EMBASE, Web of Science, and Cochrane library, to find out those studies that measured MDA in patients with OSA compared to controls. RESULTS: The search produced 563 records and after removing duplicates, 383 records remained. Screening by title and abstract and the evaluation of the full text resulted in the selection of 14 articles, which were included in the meta-analysis. Pooled analysis demonstrated higher levels of MDA in the patients compared to the controls (SMD (95% CI): 1.18 (0.68, 1.68), p < 0.0001). CONCLUSION: The results of this meta-analysis demonstrated considerable elevation of MDA in patients with OSA compared to controls. The meta-analysis also indicated a positive association of MDA levels with the degree of severity of OSA. These results suggest a state of increased lipid peroxidation in patients with OSA.
PURPOSE: Obstructive sleep apnea (OSA) is a prevalent sleep disorder associated with increased risk of cardiovascular disease. Several studies have demonstrated elevated oxidative stress in patients with OSA. This oxidative stress is a direct inducer of lipid peroxidation. Malondialdehyde (MDA), a robust marker of lipid peroxidation, has been evaluated in patients with OSA but results have been inconsistent. The present systematic review and meta-analysis was performed to quantify the circulating levels of MDA in patients with OSA compared to controls. METHODS: Search was performed in data bases of PubMed, Scopus, EMBASE, Web of Science, and Cochrane library, to find out those studies that measured MDA in patients with OSA compared to controls. RESULTS: The search produced 563 records and after removing duplicates, 383 records remained. Screening by title and abstract and the evaluation of the full text resulted in the selection of 14 articles, which were included in the meta-analysis. Pooled analysis demonstrated higher levels of MDA in the patients compared to the controls (SMD (95% CI): 1.18 (0.68, 1.68), p < 0.0001). CONCLUSION: The results of this meta-analysis demonstrated considerable elevation of MDA in patients with OSA compared to controls. The meta-analysis also indicated a positive association of MDA levels with the degree of severity of OSA. These results suggest a state of increased lipid peroxidation in patients with OSA.
Authors: Habibolah Khazaie; Farid Najafi; Leeba Rezaie; Masoud Tahmasian; Amir Ali Sepehry; Felix J F Herth Journal: Arch Iran Med Date: 2011-09 Impact factor: 1.354
Authors: Maria Carmina Pau; Elisabetta Zinellu; Sara S Fois; Barbara Piras; Gianfranco Pintus; Ciriaco Carru; Arduino A Mangoni; Alessandro G Fois; Angelo Zinellu; Pietro Pirina Journal: Antioxidants (Basel) Date: 2021-06-29