Ronald Gavidia1, Galit Levi Dunietz1, Louise O'Brien1, Carol Shannon2, Sonja Schuetz1, Matthew Spector3, Paul Swiecicki4, Ronald D Chervin1. 1. Division of Sleep Medicine, Department of Neurology, University of Michigan, Ann Arbor, Michigan. 2. Taubman Health Sciences Library, University of Michigan, Ann Arbor, Michigan. 3. Department of Otolaryngology and Head and Neck Surgery, University of Michigan, Ann Arbor, Michigan. 4. Division of Hematology and Oncology, Department of Internal Medicine, University of Michigan, Ann Arbor, Michigan.
Abstract
STUDY OBJECTIVES: Head and neck cancers (HNCs) may modify the upper airway anatomy and thereby increase the risk for obstructive sleep apnea (OSA). If untreated, OSA is associated with adverse outcomes. Identification of risk factors for OSA in patients with HNC is essential to promote proper evaluation, treatment, and improvement of sleep-related outcomes. In this review, we assessed associations between tumor stage, cancer treatment, and OSA in the population with HNC. METHODS: A systematic search of PubMed, EMBASE (Embase.com), Cochrane Library (Cochranelibrary.com), Scopus, and Web of Science was conducted to identify articles related to OSA in patients with HNC. A total of 215 articles were identified, of which 14 were included in the qualitative synthesis. These studies included 387 participants. RESULTS: The most common cancer type, tumor location, and cancer therapy were squamous cell carcinoma, oropharynx, and surgery, respectively. Three of six articles reported an association between surgical treatment and OSA. Conversely, associations between tumor stage, radiotherapy, and OSA were found in only a minority of studies (15%). The prevalence of OSA was between 57% and 76% pre-cancer therapy and 12% and 96% afterward. CONCLUSIONS: This review suggests a potential association between HNC surgery and OSA. An association between tumor stage, radiotherapy to the head and neck, and OSA is inconclusive. Further research is needed to examine the relationship between HNC and OSA.
STUDY OBJECTIVES: Head and neck cancers (HNCs) may modify the upper airway anatomy and thereby increase the risk for obstructive sleep apnea (OSA). If untreated, OSA is associated with adverse outcomes. Identification of risk factors for OSA in patients with HNC is essential to promote proper evaluation, treatment, and improvement of sleep-related outcomes. In this review, we assessed associations between tumor stage, cancer treatment, and OSA in the population with HNC. METHODS: A systematic search of PubMed, EMBASE (Embase.com), Cochrane Library (Cochranelibrary.com), Scopus, and Web of Science was conducted to identify articles related to OSA in patients with HNC. A total of 215 articles were identified, of which 14 were included in the qualitative synthesis. These studies included 387 participants. RESULTS: The most common cancer type, tumor location, and cancer therapy were squamous cell carcinoma, oropharynx, and surgery, respectively. Three of six articles reported an association between surgical treatment and OSA. Conversely, associations between tumor stage, radiotherapy, and OSA were found in only a minority of studies (15%). The prevalence of OSA was between 57% and 76% pre-cancer therapy and 12% and 96% afterward. CONCLUSIONS: This review suggests a potential association between HNC surgery and OSA. An association between tumor stage, radiotherapy to the head and neck, and OSA is inconclusive. Further research is needed to examine the relationship between HNC and OSA.
Authors: Chamara V Senaratna; Jennifer L Perret; Caroline J Lodge; Adrian J Lowe; Brittany E Campbell; Melanie C Matheson; Garun S Hamilton; Shyamali C Dharmage Journal: Sleep Med Rev Date: 2016-07-18 Impact factor: 11.609
Authors: Ronald Gavidia; Galit Levi Dunietz; Louise M O'Brien; Sonja G Schütz; Matthew E Spector; Paul L Swiecicki; Ronald D Chervin Journal: J Clin Sleep Med Date: 2022-06-01 Impact factor: 4.324