Justin J Park1, Chrysovalantis Stafylis1, Daniel D Pearce, Jeff Taylor2, Susan J Little3, Noah Kojima1, Aleksandr M Gorin1, Jeffrey D Klausner4. 1. From the Department of Medicine at the David Geffen School of Medicine at University of California, Los Angeles, Los Angeles. 2. HIV + Aging Research Project-Palm Springs, Palm Springs. 3. Department of Medicine at the University of California, San Diego School of Medicine, La Jolla. 4. Department of Preventive Medicine at the Keck School of Medicine of USC, Los Angeles, CA.
Abstract
BACKGROUND: Prophylactic administration of doxycycline is regarded as a potential new public health strategy to combat the rising rates of Chlamydia trachomatis infections and syphilis among men who have sex with men. We conducted a survey-based study to evaluate how community members and health care providers in Southern California would perceive doxycycline preexposure/postexposure prophylaxis (PrEP/PEP) to predict its acceptability and identify potential areas of concern. METHODS: We conducted an online cross-sectional survey among community members who identify as men who have sex with men and health care providers with prescribing authority in Southern California to investigate the current attitudes toward doxycycline PrEP/PEP, including their willingness to accept. We analyzed the data using descriptive statistics and binary logistic regression. RESULTS: Among 212 enrolled community member participants, 67.5% indicated they would take doxycycline PrEP/PEP if offered by their provider. Higher acceptability was significantly associated with several characteristics, including recent history of bacterial sexually transmitted infection diagnosis and current use of HIV PrEP. For health care providers, 89.5% of 76 enrolled participants expressed willingness to prescribe doxycycline PrEP/PEP to their patients if recommended by the Centers for Disease Control and Prevention, but only 43.4% were willing if not. Both community members and health care providers demonstrated high levels of concern toward possible drug resistance. CONCLUSIONS: Doxycycline PrEP/PEP as a preventive strategy against chlamydial infections and syphilis would likely be accepted among community members and health care providers. Clear guidelines from public health officials and further clarification on the strategy's potential impact on developing drug resistance may be necessary to ensure successful implementation.
BACKGROUND: Prophylactic administration of doxycycline is regarded as a potential new public health strategy to combat the rising rates of Chlamydia trachomatis infections and syphilis among men who have sex with men. We conducted a survey-based study to evaluate how community members and health care providers in Southern California would perceive doxycycline preexposure/postexposure prophylaxis (PrEP/PEP) to predict its acceptability and identify potential areas of concern. METHODS: We conducted an online cross-sectional survey among community members who identify as men who have sex with men and health care providers with prescribing authority in Southern California to investigate the current attitudes toward doxycycline PrEP/PEP, including their willingness to accept. We analyzed the data using descriptive statistics and binary logistic regression. RESULTS: Among 212 enrolled community member participants, 67.5% indicated they would take doxycycline PrEP/PEP if offered by their provider. Higher acceptability was significantly associated with several characteristics, including recent history of bacterial sexually transmitted infection diagnosis and current use of HIV PrEP. For health care providers, 89.5% of 76 enrolled participants expressed willingness to prescribe doxycycline PrEP/PEP to their patients if recommended by the Centers for Disease Control and Prevention, but only 43.4% were willing if not. Both community members and health care providers demonstrated high levels of concern toward possible drug resistance. CONCLUSIONS: Doxycycline PrEP/PEP as a preventive strategy against chlamydial infections and syphilis would likely be accepted among community members and health care providers. Clear guidelines from public health officials and further clarification on the strategy's potential impact on developing drug resistance may be necessary to ensure successful implementation.
Authors: Michalina A Montaño; Julia C Dombrowski; Sayan Dasgupta; Matthew R Golden; Ann Duerr; Lisa E Manhart; Lindley A Barbee; Christine M Khosropour Journal: AIDS Behav Date: 2019-02
Authors: David P Wilson; Garrett P Prestage; Richard T Gray; Alexander Hoare; Pol McCann; Ian Down; Rebecca J Guy; Fraser Drummond; Jeffrey D Klausner; Basil Donovan; John M Kaldor Journal: Sex Transm Dis Date: 2011-07 Impact factor: 2.830
Authors: Michael W Traeger; Sophia E Schroeder; Edwina J Wright; Margaret E Hellard; Vincent J Cornelisse; Joseph S Doyle; Mark A Stoové Journal: Clin Infect Dis Date: 2018-08-16 Impact factor: 9.079
Authors: Matthew A Spinelli; Hyman M Scott; Eric Vittinghoff; Albert Y Liu; Kenneth Coleman; Susan P Buchbinder Journal: Sex Transm Dis Date: 2019-04 Impact factor: 2.830
Authors: Juliana S Grant; Chrysovalantis Stafylis; Connie Celum; Troy Grennan; Bridget Haire; John Kaldor; Anne F Luetkemeyer; John M Saunders; Jean-Michel Molina; Jeffrey D Klausner Journal: Clin Infect Dis Date: 2020-03-03 Impact factor: 9.079