| Literature DB >> 3355844 |
O K Tollersrud1, S H Hofmann, N N Aronson.
Abstract
Rat liver glycosylasparaginase (N4-(beta-N-acetyl-D-glucosaminyl)-L-asparagine amidohydrolase (EC 3.5.1.26) was irreversibly inhibited in vitro by the asparagine analogue 5-diazo-4-oxo-L-norvaline (DONV). Following the abolition of this lysosomal hydrolase by DONV in rats, the enzyme activity in liver recovered exponentially. Assuming a zero order rate of protein synthesis, the half-life of the glycosylasparaginase in rat liver was measured to be 2 days.Entities:
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Year: 1988 PMID： 3355844 DOI： 10.1016/0167-4838(88)90044-1
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002