Literature DB >> 33558431

How Postdoctoral Research in Paul Greengard's Laboratory Shaped My Scientific Career, Although I Never Did Another Phosphorylation Assay.

Annette C Dolphin1.   

Abstract

In this short review, I describe from personal experience how every step in the career of any scientist, no matter how disjointed and pragmatic each might seem at the time, will almost inevitably meld together, to help us all tackle novel projects. My postdoctoral research in Paul Greengard's laboratory, where I investigated neurotransmitter-mediated phosphorylation of Synapsin I, was instrumental in my career progression, and Paul's support was instrumental in my ability to make a leap into independent research.
Copyright © 2021 the authors.

Entities:  

Year:  2021        PMID: 33558431      PMCID: PMC8018760          DOI: 10.1523/JNEUROSCI.3002-20.2021

Source DB:  PubMed          Journal:  J Neurosci        ISSN: 0270-6474            Impact factor:   6.167


  72 in total

Review 1.  Multiplicity of mechanisms of serotonin receptor signal transduction.

Authors:  J R Raymond; Y V Mukhin; A Gelasco; J Turner; G Collinsworth; T W Gettys; J S Grewal; M N Garnovskaya
Journal:  Pharmacol Ther       Date:  2001 Nov-Dec       Impact factor: 12.310

2.  Synaptic vesicle mobilization is regulated by distinct synapsin I phosphorylation pathways at different frequencies.

Authors:  Ping Chi; Paul Greengard; Timothy A Ryan
Journal:  Neuron       Date:  2003-04-10       Impact factor: 17.173

3.  Interaction via a key tryptophan in the I-II linker of N-type calcium channels is required for beta1 but not for palmitoylated beta2, implicating an additional binding site in the regulation of channel voltage-dependent properties.

Authors:  Jérôme Leroy; Mark W Richards; Mark S Richards; Adrian J Butcher; Manuela Nieto-Rostro; Wendy S Pratt; Anthony Davies; Annette C Dolphin
Journal:  J Neurosci       Date:  2005-07-27       Impact factor: 6.167

4.  Three types of neuronal calcium channel with different calcium agonist sensitivity.

Authors:  M C Nowycky; A P Fox; R W Tsien
Journal:  Nature       Date:  1985 Aug 1-7       Impact factor: 49.962

5.  Primary structure of the receptor for calcium channel blockers from skeletal muscle.

Authors:  T Tanabe; H Takeshima; A Mikami; V Flockerzi; H Takahashi; K Kangawa; M Kojima; H Matsuo; T Hirose; S Numa
Journal:  Nature       Date:  1987 Jul 23-29       Impact factor: 49.962

6.  Neurotransmitters decrease the calcium ocmponent of sensory neurone action potentials.

Authors:  K Dunlap; G D Fischbach
Journal:  Nature       Date:  1978 Dec 21-28       Impact factor: 49.962

7.  Differential phosphorylation of multiple sites in purified protein I by cyclic AMP-dependent and calcium-dependent protein kinases.

Authors:  W B Huttner; L J DeGennaro; P Greengard
Journal:  J Biol Chem       Date:  1981-02-10       Impact factor: 5.157

8.  The novel anticonvulsant drug, gabapentin (Neurontin), binds to the alpha2delta subunit of a calcium channel.

Authors:  N S Gee; J P Brown; V U Dissanayake; J Offord; R Thurlow; G N Woodruff
Journal:  J Biol Chem       Date:  1996-03-08       Impact factor: 5.157

Review 9.  DARPP-32: an integrator of neurotransmission.

Authors:  Per Svenningsson; Akinori Nishi; Gilberto Fisone; Jean-Antoine Girault; Angus C Nairn; Paul Greengard
Journal:  Annu Rev Pharmacol Toxicol       Date:  2004       Impact factor: 13.820

10.  α2δ expression sets presynaptic calcium channel abundance and release probability.

Authors:  Michael B Hoppa; Beatrice Lana; Wojciech Margas; Annette C Dolphin; Timothy A Ryan
Journal:  Nature       Date:  2012-05-13       Impact factor: 49.962

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