Daniel A Norman1,2, Rosanne Barnes3, Rebecca Pavlos3, Mejbah Bhuiyan3, Kefyalew Addis Alene3,4, Margie Danchin5,6,7, Holly Seale8, Hannah C Moore3, Christopher C Blyth3,2,9,10. 1. Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Western Australia, Australia; daniel.norman@telethonkids.org.au. 2. School of Medicine, University of Western Australia, Western Australia, Australia. 3. Wesfarmers Centre of Vaccines and Infectious Diseases, Telethon Kids Institute, Western Australia, Australia. 4. Faculty of Health Sciences, Curtin University, Western Australia, Australia. 5. Department of General Medicine, The Royal Children's Hospital, Victoria, Australia. 6. Department of Pediatrics, University of Melbourne, Victoria, Australia. 7. Vaccine Hesitancy, Murdoch Children's Research Institute, Victoria, Australia. 8. School of Population Health, University of New South Wales, New South Wales, Australia. 9. Department of Infectious Diseases, Perth Children's Hospital, Western Australia, Australia; and. 10. Department of Microbiology, PathWest Laboratory Medicine, Western Australia, Australia.
Abstract
CONTEXT: Children with medical comorbidities are at greater risk for severe influenza and poorer clinical outcomes. Despite recommendations and funding, influenza vaccine coverage remains inadequate in these children. OBJECTIVE: We aimed to systematically review literature assessing interventions targeting influenza vaccine coverage in children with comorbidities and assess the impact on influenza vaccine coverage. DATA SOURCES: PubMed, Scopus, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database, and Web of Science databases were searched. STUDY SELECTION: Interventions targeting influenza vaccine coverage in children with medical comorbidities. DATA EXTRACTION: Two reviewers independently screened articles, extracting studies' methods, interventions, settings, populations, and results. Four reviewers independently assessed risk of bias. RESULTS: From 961 screened articles, 35 met inclusion criteria. Published studies revealed that influenza vaccine coverage was significantly improved through vaccination reminders and education directed at either patients' parents or providers, as well as by vaccination-related clinic process changes. Interventions improved influenza vaccine coverage by an average 60%, but no significant differences between intervention types were detected. Significant bias and study heterogeneity were also identified, limiting confidence in this effect estimate. LIMITATIONS: A high risk of bias and overall low quality of evidence limited our capacity to assess intervention types and methods. CONCLUSIONS: Interventions were shown to consistently improve influenza vaccine coverage; however, no significant differences in coverage between different intervention types were observed. Future well-designed studies evaluating the effectiveness of different intervention are required to inform future optimal interventions.
CONTEXT: Children with medical comorbidities are at greater risk for severe influenza and poorer clinical outcomes. Despite recommendations and funding, influenza vaccine coverage remains inadequate in these children. OBJECTIVE: We aimed to systematically review literature assessing interventions targeting influenza vaccine coverage in children with comorbidities and assess the impact on influenza vaccine coverage. DATA SOURCES: PubMed, Scopus, Embase, Cumulative Index to Nursing and Allied Health Literature, Cochrane Central Register of Controlled Trials, Allied and Complementary Medicine Database, and Web of Science databases were searched. STUDY SELECTION: Interventions targeting influenza vaccine coverage in children with medical comorbidities. DATA EXTRACTION: Two reviewers independently screened articles, extracting studies' methods, interventions, settings, populations, and results. Four reviewers independently assessed risk of bias. RESULTS: From 961 screened articles, 35 met inclusion criteria. Published studies revealed that influenza vaccine coverage was significantly improved through vaccination reminders and education directed at either patients' parents or providers, as well as by vaccination-related clinic process changes. Interventions improved influenza vaccine coverage by an average 60%, but no significant differences between intervention types were detected. Significant bias and study heterogeneity were also identified, limiting confidence in this effect estimate. LIMITATIONS: A high risk of bias and overall low quality of evidence limited our capacity to assess intervention types and methods. CONCLUSIONS: Interventions were shown to consistently improve influenza vaccine coverage; however, no significant differences in coverage between different intervention types were observed. Future well-designed studies evaluating the effectiveness of different intervention are required to inform future optimal interventions.
Authors: Jane Tuckerman; Kelly Harper; Thomas R Sullivan; Jennifer Fereday; Jennifer Couper; Nicholas Smith; Andrew Tai; Andrew Kelly; Richard Couper; Mark Friswell; Louise Flood; Margaret Danchin; Christopher C Blyth; Helen Marshall Journal: BMJ Open Date: 2022-02-10 Impact factor: 2.692
Authors: Daniel A Norman; Allen C Cheng; Kristine K Macartney; Hannah C Moore; Margie Danchin; Holly Seale; Jocelynne McRae; Julia E Clark; Helen S Marshall; Jim Buttery; Joshua R Francis; Nigel W Crawford; Christopher C Blyth Journal: Influenza Other Respir Viruses Date: 2021-11-16 Impact factor: 4.380
Authors: Hassen Mohammed; Mark McMillan; Prabha H Andraweera; Salenna R Elliott; Helen S Marshall Journal: Hum Vaccin Immunother Date: 2021-10-08 Impact factor: 3.452