| Literature DB >> 33558003 |
Frances M K Williams1, Maxim B Freidin1, Massimo Mangino1,2, Simon Couvreur1, Alessia Visconti1, Ruth C E Bowyer1, Caroline I Le Roy1, Mario Falchi1, Olatz Mompeó1, Carole Sudre3, Richard Davies4, Christopher Hammond1, Cristina Menni1, Claire J Steves1, Tim D Spector1.
Abstract
Susceptibility to infection such as SARS-CoV-2 may be influenced by host genotype. TwinsUK volunteers (n = 3261) completing the C-19 COVID-19 symptom tracker app allowed classical twin studies of COVID-19 symptoms, including predicted COVID-19, a symptom-based algorithm to predict true infection, derived from app users tested for SARS-CoV-2. We found heritability of 49% (32-64%) for delirium; 34% (20-47%) for diarrhea; 31% (8-52%) for fatigue; 19% (0-38%) for anosmia; 46% (31-60%) for skipped meals and 31% (11-48%) for predicted COVID-19. Heritability estimates were not affected by cohabiting or by social deprivation. The results suggest the importance of host genetics in the risk of clinical manifestations of COVID-19 and provide grounds for planning genome-wide association studies to establish specific genes involved in viral infectivity and the host immune response.Entities:
Keywords: COVID-19; SARS-CoV-2; anosmia; heritability; twins
Year: 2020 PMID： 33558003 DOI： 10.1017/thg.2020.85
Source DB: PubMed Journal: Twin Res Hum Genet ISSN： 1832-4274 Impact factor: 1.587