BACKGROUND: Guidelines for stopping coronavirus disease 2019 patient isolation are mainly symptom-based, with isolation for 10 to 20 days depending on their condition. METHODS: In this study, we describe 3 deeply immunocompromised patients, each with different clinical evolutions. We observed (1) the patients' epidemiological, clinical, and serological data, (2) infectiousness using viral culture, and (3) viral mutations accumulated over time. RESULTS: Asymptomatic carriage, symptom resolution, or superinfection with a second severe acute respiratory syndrome coronavirus 2 strain were observed, all leading to prolonged infectious viral shedding for several months. CONCLUSIONS: Understanding underlying mechanisms and frequency of prolonged infectiousness is crucial to adapt current guidelines and strengthen the use of systematic polymerase chain reaction testing before stopping isolation in immunocompromised populations.
BACKGROUND: Guidelines for stopping coronavirus disease 2019 patient isolation are mainly symptom-based, with isolation for 10 to 20 days depending on their condition. METHODS: In this study, we describe 3 deeply immunocompromised patients, each with different clinical evolutions. We observed (1) the patients' epidemiological, clinical, and serological data, (2) infectiousness using viral culture, and (3) viral mutations accumulated over time. RESULTS: Asymptomatic carriage, symptom resolution, or superinfection with a second severe acute respiratory syndrome coronavirus 2 strain were observed, all leading to prolonged infectious viral shedding for several months. CONCLUSIONS: Understanding underlying mechanisms and frequency of prolonged infectiousness is crucial to adapt current guidelines and strengthen the use of systematic polymerase chain reaction testing before stopping isolation in immunocompromised populations.
Authors: Joel O Wertheim; Jade C Wang; Mindy Leelawong; Darren P Martin; Jennifer L Havens; Moinuddin A Chowdhury; Jonathan E Pekar; Helly Amin; Anthony Arroyo; Gordon A Awandare; Hoi Yan Chow; Edimarlyn Gonzalez; Elizabeth Luoma; Collins M Morang'a; Anton Nekrutenko; Stephen D Shank; Stefan Silver; Peter K Quashie; Jennifer L Rakeman; Victoria Ruiz; Lucia V Torian; Tetyana I Vasylyeva; Sergei L Kosakovsky Pond; Scott Hughes Journal: Nat Commun Date: 2022-06-25 Impact factor: 17.694
Authors: Nathan M Markarian; Gaël Galli; Dhanesh Patel; Mark Hemmings; Priya Nagpal; Albert M Berghuis; Levon Abrahamyan; Silvia M Vidal Journal: Front Microbiol Date: 2022-07-01 Impact factor: 6.064
Authors: Hui Chen; Zhao Li; Sheng Feng; Melissa Richard-Greenblatt; Emily Hutson; Stefen Andrianus; Laurel J Glaser; Kyle G Rodino; Jianing Qian; Dinesh Jayaraman; Ronald G Collman; Abigail Glascock; Frederic D Bushman; Jae Seung Lee; Sara Cherry; Alejandra Fausto; Susan R Weiss; Hyun Koo; Patricia M Corby; Alfonso Oceguera; Una O'Doherty; Alfred L Garfall; Dan T Vogl; Edward A Stadtmauer; Ping Wang Journal: Clin Chem Date: 2021-12-30 Impact factor: 8.327
Authors: Manish C Choudhary; Charles R Crain; Xueting Qiu; William Hanage; Jonathan Z Li Journal: Clin Infect Dis Date: 2022-01-29 Impact factor: 9.079
Authors: Abeer N Alshukairi; Sherif A El-Kafrawy; Ashraf Dada; Mohamed Yasir; Amani H Yamani; Mohammed F Saeedi; Ahmed Aljohaney; Naif I AlJohani; Husam A Bahaudden; Intikhab Alam; Takashi Gojobori; Aleksandar Radovanovic; Thamir A Alandijany; Norah A Othman; Tagreed L Alsubhi; Ahmed M Hassan; Ahmed M Tolah; Jaffar A Al-Tawfiq; Alimuddin Zumla; Esam I Azhar Journal: Int J Infect Dis Date: 2021-07-18 Impact factor: 3.623