Seongho Seo1, Ye-Ha Jung2, Dasom Lee2, Won Joon Lee3, Joon Hwan Jang2,4, Jae-Yeon Lee2, Soo-Hee Choi5, Jee Youn Moon6, Jae Sung Lee7,8,9, Gi Jeong Cheon8,9, Do-Hyung Kang10. 1. Department of Electronic Engineering, Pai Chai University, Daejeon, Republic of Korea. 2. Department of Psychiatry, Seoul National University Hospital, Seoul, Republic of Korea. 3. Department of Psychiatry, Kangdong Sacred Heart Hospital, Seoul, Republic of Korea. 4. Department of Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. 5. Department of Psychiatry, Seoul National University College of Medicine and Institute of Human Behavioral Medicine, SNU-MRC, Seoul, Republic of Korea. 6. Department of Anesthesiology and Pain Medicine, Seoul National University Hospital, Seoul, Republic of Korea. 7. Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul, Republic of Korea. 8. Institute of Radiation Medicine, Medical Research Center, Seoul National University, Seoul, Republic of Korea. 9. Department of Nuclear Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea. 10. Emotional Information and Communication Technology Association, Seoul, Republic of Korea.
Abstract
PURPOSE: Fibromyalgia (FM) and complex regional pain syndrome (CRPS) share many pathological mechanisms related to chronic pain and neuroinflammation, which may contribute to the multifactorial pathological mechanisms in both FM and CRPS. The aim of this study was to assess neuroinflammation in FM patients compared with that in patients with CRPS and healthy controls. METHODS: Neuroinflammation was measured as the distribution volume ratio (DVR) of [11C]-(R)-PK11195 positron emission tomography (PET) in 12 FM patients, 11 patients with CRPS and 15 healthy controls. RESULTS: Neuroinflammation in FM patients was significantly higher in the left pre (primary motor cortex) and post (primary somatosensory cortex) central gyri (p < 0.001), right postcentral gyrus (p < 0.005), left superior parietal and superior frontal gyri (p < 0.005), left precuneus (p < 0.01), and left medial frontal gyrus (p = 0.036) compared with healthy controls. Furthermore, the DVR of [11C]-(R)-PK11195 in FM patients demonstrated decreased neuroinflammation in the medulla (p < 0.005), left superior temporal gyrus (p < 0.005), and left amygdala (p = 0.020) compared with healthy controls. CONCLUSIONS: To the authors' knowledge, this report is the first to describe abnormal neuroinflammation levels in the brains of FM patients compared with that in patients with CRPS using [11C]-(R)-PK11195 PET. The results suggested that abnormal neuroinflammation can be an important pathological factor in FM. In addition, the identification of common and different critical regions related to abnormal neuroinflammation in FM, compared with patients with CRPS and healthy controls, may contribute to improved diagnosis and the development of effective medical treatment for patients with FM.
PURPOSE:Fibromyalgia (FM) and complex regional pain syndrome (CRPS) share many pathological mechanisms related to chronic pain and neuroinflammation, which may contribute to the multifactorial pathological mechanisms in both FM and CRPS. The aim of this study was to assess neuroinflammation in FMpatients compared with that in patients with CRPS and healthy controls. METHODS: Neuroinflammation was measured as the distribution volume ratio (DVR) of [11C]-(R)-PK11195 positron emission tomography (PET) in 12 FMpatients, 11 patients with CRPS and 15 healthy controls. RESULTS: Neuroinflammation in FMpatients was significantly higher in the left pre (primary motor cortex) and post (primary somatosensory cortex) central gyri (p < 0.001), right postcentral gyrus (p < 0.005), left superior parietal and superior frontal gyri (p < 0.005), left precuneus (p < 0.01), and left medial frontal gyrus (p = 0.036) compared with healthy controls. Furthermore, the DVR of [11C]-(R)-PK11195 in FMpatients demonstrated decreased neuroinflammation in the medulla (p < 0.005), left superior temporal gyrus (p < 0.005), and left amygdala (p = 0.020) compared with healthy controls. CONCLUSIONS: To the authors' knowledge, this report is the first to describe abnormal neuroinflammation levels in the brains of FMpatients compared with that in patients with CRPS using [11C]-(R)-PK11195 PET. The results suggested that abnormal neuroinflammation can be an important pathological factor in FM. In addition, the identification of common and different critical regions related to abnormal neuroinflammation in FM, compared with patients with CRPS and healthy controls, may contribute to improved diagnosis and the development of effective medical treatment for patients with FM.
Authors: Markus Burgmer; Markus Gaubitz; Carsten Konrad; Marco Wrenger; Sebastian Hilgart; Gereon Heuft; Bettina Pfleiderer Journal: Psychosom Med Date: 2009-05-04 Impact factor: 4.312
Authors: Kornelis S M van der Geest; Maria Sandovici; Pieter H Nienhuis; Riemer H J A Slart; Peter Heeringa; Elisabeth Brouwer; William F Jiemy Journal: Front Med (Lausanne) Date: 2022-06-06