Literature DB >> 3355610

Flordipine, a calcium channel blocker, which does not influence lipidemia or atherosclerosis in cholesterol-fed rabbits.

D Kritchevsky1, S A Tepper, D M Klurfeld.   

Abstract

Data relating to the effects of calcium channel blockers on experimental atherosclerosis in rabbits are inconsistent with most studies finding no effect on either serum lipids or atherosclerosis. We have administered flordipine (5, 15 or 45 mg/kg/day) for 10 weeks to rabbits fed 1% cholesterol and 4% corn oil. At no level of treatment was there an effect on serum or liver lipids or on aortic sudanophilia.

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Year:  1988        PMID： 3355610     DOI： 10.1016/0021-9150(88)90292-4

Source DB:  PubMed          Journal:  Atherosclerosis        ISSN： 0021-9150            Impact factor:   5.162


  4 in total

1.  Quantitative analysis of antiatherosclerotic effect of nifedipine in cholesterol-fed rabbits.

Authors:  Y Ohta; N Higuchi; S Emura; T Takashima; K Oogushi; H Kato; K Ohmori; T Sunaga
Journal:  Cardiovasc Drugs Ther       Date:  1990-08       Impact factor: 3.727

2.  Differential effects of AT1 receptor and Ca2+ channel blockade on atherosclerosis, inflammatory gene expression, and production of reactive oxygen species.

Authors:  Derek E Doran; Daiana Weiss; Yong Zhang; Kathy K Griendling; W Robert Taylor
Journal:  Atherosclerosis       Date:  2007-01-16       Impact factor: 5.162

3.  Differential and interactive effects of calcium channel blockers and cholesterol content of the diet on jejunal uptake of lipids in rabbits.

Authors:  D A Hyson; A B Thomson; C T Kappagoda
Journal:  Lipids       Date:  1994-04       Impact factor: 1.880

Review 4.  Concept of an antiatherosclerotic efficacy of calcium entry blockers. INTACT Investigators.

Authors:  S Jost; W Rafflenbeul; J Deckers; B Wiese; H Hecker; P Nikutta; P Lippolt; P Lichtlen
Journal:  Eur J Epidemiol       Date:  1992-05       Impact factor: 8.082
  4 in total

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