Literature DB >> 3355604

Action of the nonsteroidal anti-inflammatory agent, flufenamic acid, on calcium movements in isolated mitochondria.

P McDougall1, A Markham, I Cameron, A J Sweetman.   

Abstract

The anti-inflammatory agent flufenamic acid was found to inhibit calcium uptake in isolated mitochondria at low concentrations (IC50 = 7.2 microM). Similar concentrations were required to promote the release of calcium from mitochondria preloaded with the cation (EC50 = 3.5 microM). Identical actions were found with diflunisal, mefenanamic acid and 2,4-dinitrophenol. It was concluded that flufenamic acid was affecting calcium movements across the mitochondrial membrane by virtue of its ability to uncouple oxidative phosphorylation.

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Year:  1988        PMID： 3355604     DOI： 10.1016/0006-2952(88)90790-3

Source DB:  PubMed          Journal:  Biochem Pharmacol        ISSN： 0006-2952            Impact factor:   5.858


  6 in total

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2.  Flufenamic acid as an inducer of mitochondrial permeability transition.

Authors:  M C Jordani; A C Santos; I M Prado; S A Uyemura; C Curti
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Authors:  Rebecca Rachael Foster; Gavin I Welsh; Simon C Satchell; Robin D Marlow; Mathew D Wherlock; Debora Pons; Peter W Mathieson; David O Bates; Moin A Saleem
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  6 in total

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