| Literature DB >> 33554240 |
Tunay Kökten1, Franck Hansmannel1, Ndeye Coumba Ndiaye1, Anne-Charlotte Heba1, Didier Quilliot1,2, Natacha Dreumont1, Djésia Arnone1, Laurent Peyrin-Biroulet1,3.
Abstract
Immoderate calorie intake coupled with a sedentary lifestyle are major determinants of health issues and inflammatory diseases in modern society. The balance between energy consumption and energy expenditure is critical for longevity. Excessive energy intake and adiposity cause systemic inflammation, whereas calorie restriction (CR) without malnutrition, exerts a potent anti-inflammatory effect. The objective of this review was to provide an overview of different strategies used to reduce calorie intake, discuss physiological mechanisms by which CR might lead to improved health outcomes, and summarize the present knowledge about inflammatory diseases. We discuss emerging data of observational studies and randomized clinical trials on CR that have been shown to reduce inflammation and improve human health.Entities:
Keywords: autophagy; caloric restriction; endoplasmic reticulum stress; fasting; gut microbiota; inflammatory disease; metabolic switch
Mesh：
Year: 2021 PMID： 33554240 PMCID： PMC8321869 DOI： 10.1093/advances/nmaa179
Source DB: PubMed Journal: Adv Nutr ISSN： 2161-8313 Impact factor: 8.701