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Literature DB >> 33553964

Cis-interactions Make Immune Checkpoint Blockade More Trans-parent.

Natasha Khatwani^1,2, Asha B Pillai^1,2.

Abstract

PD-L1:CD80 cis-heterodimer formation preferentially blocks CTLA-4 trans-signaling while allowing CD28-mediated effector T cell activation.

Entities: Chemical

Mesh：

Substances：

Year: 2020 PMID： 33553964 PMCID： PMC7861137 DOI： 10.1126/sciimmunol.aba7107

Source DB: PubMed Journal: Sci Immunol ISSN： 2470-9468

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References

1 in total

1. PD-L1:CD80 Cis-Heterodimer Triggers the Co-stimulatory Receptor CD28 While Repressing the Inhibitory PD-1 and CTLA-4 Pathways.

Authors: Yunlong Zhao; Calvin K Lee; Chia-Hao Lin; Rodrigo B Gassen; Xiaozheng Xu; Zhe Huang; Changchun Xiao; Cristina Bonorino; Li-Fan Lu; Jack D Bui; Enfu Hui
Journal: Immunity Date: 2019-11-19 Impact factor: 31.745

1 in total