Literature DB >> 33553601

Ca2+ transfer to mitochondria: a spark of life in unexpected conditions.

Eduardo Silva-Pavez1,2, Ulises Ahumada-Castro1,2, Alenka Lovy1,2,3, Julio Cesar Cárdenas1,2,4,5.   

Abstract

The inositol 1,4,5-triphosphate receptor (InsP3R)-mediated calcium (Ca2+) transfer to mitochondria is important to maintain mitochondrial respiration and bioenergetics in normal and cancer cells, even though cancer cells have defective oxidative phosphorylation (OXPHOS). Here, we discuss how tumor mitochondria could become a feasible therapeutic target to treat tumors that depend on reductive carboxylation.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Calcium; OXPHOS; autophagy; cancer; cell survival

Year:  2020        PMID： 33553601      PMCID： PMC7849767          DOI： 10.1080/23723556.2020.1839341

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  10 in total

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Authors:  O WARBURG
Journal:  Science       Date:  1956-02-24       Impact factor: 47.728

2.  Oxidation of alpha-ketoglutarate is required for reductive carboxylation in cancer cells with mitochondrial defects.

Authors:  Andrew R Mullen; Zeping Hu; Xiaolei Shi; Lei Jiang; Lindsey K Boroughs; Zoltan Kovacs; Richard Boriack; Dinesh Rakheja; Lucas B Sullivan; W Marston Linehan; Navdeep S Chandel; Ralph J DeBerardinis
Journal:  Cell Rep       Date:  2014-05-22       Impact factor: 9.423

Review 3.  Mitochondria and Cancer.

Authors:  Sejal Vyas; Elma Zaganjor; Marcia C Haigis
Journal:  Cell       Date:  2016-07-28       Impact factor: 41.582

4.  Essential regulation of cell bioenergetics by constitutive InsP3 receptor Ca2+ transfer to mitochondria.

Authors:  César Cárdenas; Russell A Miller; Ian Smith; Thi Bui; Jordi Molgó; Marioly Müller; Horia Vais; King-Ho Cheung; Jun Yang; Ian Parker; Craig B Thompson; Morris J Birnbaum; Kenneth R Hallows; J Kevin Foskett
Journal:  Cell       Date:  2010-07-23       Impact factor: 41.582

5.  Selective Vulnerability of Cancer Cells by Inhibition of Ca(2+) Transfer from Endoplasmic Reticulum to Mitochondria.

Authors:  César Cárdenas; Marioly Müller; Andrew McNeal; Alenka Lovy; Fabian Jaňa; Galdo Bustos; Felix Urra; Natalia Smith; Jordi Molgó; J Alan Diehl; Todd W Ridky; J Kevin Foskett
Journal:  Cell Rep       Date:  2016-03-03       Impact factor: 9.423

6.  Decoding of cytosolic calcium oscillations in the mitochondria.

Authors:  G Hajnóczky; L D Robb-Gaspers; M B Seitz; A P Thomas
Journal:  Cell       Date:  1995-08-11       Impact factor: 41.582

Review 7.  Hallmarks of cancer: the next generation.

Authors:  Douglas Hanahan; Robert A Weinberg
Journal:  Cell       Date:  2011-03-04       Impact factor: 41.582

8.  Cancer cells with defective oxidative phosphorylation require endoplasmic reticulum-to-mitochondria Ca2+ transfer for survival.

Authors:  Cesar Cardenas; Alenka Lovy; Eduardo Silva-Pavez; Felix Urra; Craig Mizzoni; Ulises Ahumada-Castro; Galdo Bustos; Fabian Jaňa; Pablo Cruz; Paula Farias; Elizabeth Mendoza; Hernan Huerta; Paola Murgas; Martin Hunter; Melany Rios; Oscar Cerda; Irene Georgakoudi; Armen Zakarian; Jordi Molgó; J Kevin Foskett
Journal:  Sci Signal       Date:  2020-07-14       Impact factor: 9.517

9.  Mitochondrial Respiration Controls Lysosomal Function during Inflammatory T Cell Responses.

Authors:  Francesc Baixauli; Rebeca Acín-Pérez; Carolina Villarroya-Beltrí; Carla Mazzeo; Norman Nuñez-Andrade; Enrique Gabandé-Rodriguez; Maria Dolores Ledesma; Alberto Blázquez; Miguel Angel Martin; Juan Manuel Falcón-Pérez; Juan Miguel Redondo; Jose Antonio Enríquez; Maria Mittelbrunn
Journal:  Cell Metab       Date:  2015-08-20       Impact factor: 27.287

Review 10.  Mitochondrial metabolic remodeling in response to genetic and environmental perturbations.

Authors:  Kate E R Hollinshead; Daniel A Tennant
Journal:  Wiley Interdiscip Rev Syst Biol Med       Date:  2016-05-19
  10 in total
  1 in total

Review 1.  ER-mitochondria contact sites; a multifaceted factory for Ca2+ signaling and lipid transport.

Authors:  Maria Livia Sassano; Blanca Felipe-Abrio; Patrizia Agostinis
Journal:  Front Cell Dev Biol       Date:  2022-08-16
  1 in total

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