Literature DB >> 33553600

Targeting drug transporters to prevent chemotherapy-induced peripheral neuropathy.

Kevin M Huang1, Shuiying Hu1.   

Abstract

Chemotherapy-induced peripheral neuropathy is a debilitating toxicity that adversely affects patient quality and course of treatment. Recent findings have demonstrated that the etiology of peripheral neuropathy is dependent on transporter-mediated accumulation in dorsal root ganglia, and targeting this mechanism can afford neurological protection without compromising therapeutic efficacy.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  Chemotherapy; oxaliplatin; paclitaxel; peripheral neuropathy; solute carriers

Year:  2020        PMID： 33553600      PMCID： PMC7849748          DOI： 10.1080/23723556.2020.1838863

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  5 in total

Review 1.  Identification of Endogenous Biomarkers to Predict the Propensity of Drug Candidates to Cause Hepatic or Renal Transporter-Mediated Drug-Drug Interactions.

Authors:  Xiaoyan Chu; Grace Hoyee Chan; Raymond Evers
Journal:  J Pharm Sci       Date:  2017-04-14       Impact factor: 3.534

2.  Neuronal uptake transporters contribute to oxaliplatin neurotoxicity in mice.

Authors:  Kevin M Huang; Alix F Leblanc; Muhammad Erfan Uddin; Ji Young Kim; Mingqing Chen; Eric D Eisenmann; Alice A Gibson; Yang Li; Kristen W Hong; Duncan DiGiacomo; Sherry H Xia; Paola Alberti; Alessia Chiorazzi; Stephen N Housley; Timothy C Cope; Jason A Sprowl; Jing Wang; Charles L Loprinzi; Anne Noonan; Maryam B Lustberg; Guido Cavaletti; Navjot Pabla; Shuiying Hu; Alex Sparreboom
Journal:  J Clin Invest       Date:  2020-09-01       Impact factor: 14.808

3.  Pantoprazole, an Inhibitor of the Organic Cation Transporter 2, Does Not Ameliorate Cisplatin-Related Ototoxicity or Nephrotoxicity in Children and Adolescents with Newly Diagnosed Osteosarcoma Treated with Methotrexate, Doxorubicin, and Cisplatin.

Authors:  Elizabeth Fox; Kristin Levin; Yan Zhu; Blair Segers; Naomi Balamuth; Richard Womer; Rochelle Bagatell; Frank Balis
Journal:  Oncologist       Date:  2018-02-14

4.  OATP1B2 deficiency protects against paclitaxel-induced neurotoxicity.

Authors:  Alix F Leblanc; Jason A Sprowl; Paola Alberti; Alessia Chiorazzi; W David Arnold; Alice A Gibson; Kristen W Hong; Marissa S Pioso; Mingqing Chen; Kevin M Huang; Vamsi Chodisetty; Olivia Costa; Tatiana Florea; Peter de Bruijn; Ron H Mathijssen; Raquel E Reinbolt; Maryam B Lustberg; Lara E Sucheston-Campbell; Guido Cavaletti; Alex Sparreboom; Shuiying Hu
Journal:  J Clin Invest       Date:  2018-01-16       Impact factor: 14.808

5.  Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates.

Authors:  Kristina Hacker; Renke Maas; Johannes Kornhuber; Martin F Fromm; Oliver Zolk
Journal:  PLoS One       Date:  2015-09-01       Impact factor: 3.240
  5 in total
  1 in total

Review 1.  Boosting the oral bioavailability of anticancer drugs through intentional drug-drug interactions.

Authors:  Eric D Eisenmann; Zahra Talebi; Alex Sparreboom; Sharyn D Baker
Journal:  Basic Clin Pharmacol Toxicol       Date:  2021-06-28       Impact factor: 4.080
  1 in total

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