Literature DB >> 33553599

Mutual inactivation of two RING-finger-type E3 ubiquitin ligases during cell cycle progression.

Shizhen Zhang1, Yi Sun1.   

Abstract

CRL and APC/C belong to the RING-finger-type E3 ligases, and both play important roles in cell cycle regulation. Recently, we found that SAG, a RING component of CRL, acts as an endogenous inhibitor of APC/C by competing with APC2 for E2s binding; while APC/CCDH1 targets SAG for ubiquitylation and degradation at G1 phase. The negative crosstalk between these two E3s ensures the orderly cell cycle progression.
© 2020 Taylor & Francis Group, LLC.

Entities:  

Keywords:  APC/C; SAG; UBE2C; UBE2S; cell cycle

Year:  2020        PMID： 33553599      PMCID： PMC7849741          DOI： 10.1080/23723556.2020.1837582

Source DB:  PubMed          Journal:  Mol Cell Oncol        ISSN： 2372-3556


  9 in total

Review 1.  Mitosis and apoptosis: how is the balance set?

Authors:  Caroline H Topham; Stephen S Taylor
Journal:  Curr Opin Cell Biol       Date:  2013-07-23       Impact factor: 8.382

2.  SAG, a novel zinc RING finger protein that protects cells from apoptosis induced by redox agents.

Authors:  H Duan; Y Wang; M Aviram; M Swaroop; J A Loo; J Bian; Y Tian; T Mueller; C L Bisgaier; Y Sun
Journal:  Mol Cell Biol       Date:  1999-04       Impact factor: 4.272

3.  Neddylation E2 UBE2F Promotes the Survival of Lung Cancer Cells by Activating CRL5 to Degrade NOXA via the K11 Linkage.

Authors:  Weihua Zhou; Jie Xu; Haomin Li; Ming Xu; Zhijian J Chen; Wenyi Wei; Zhenqiang Pan; Yi Sun
Journal:  Clin Cancer Res       Date:  2016-09-02       Impact factor: 12.531

4.  Yeast homolog of human SAG/ROC2/Rbx2/Hrt2 is essential for cell growth, but not for germination: chip profiling implicates its role in cell cycle regulation.

Authors:  M Swaroop; Y Wang; P Miller; H Duan; T Jatkoe; S J Madore; Y Sun
Journal:  Oncogene       Date:  2000-06-01       Impact factor: 9.867

Review 5.  K11-linked ubiquitin chains as novel regulators of cell division.

Authors:  Katherine E Wickliffe; Adam Williamson; Hermann-Josef Meyer; Aileen Kelly; Michael Rape
Journal:  Trends Cell Biol       Date:  2011-10-04       Impact factor: 20.808

6.  SAG/RBX2 E3 ligase complexes with UBCH10 and UBE2S E2s to ubiquitylate β-TrCP1 via K11-linkage for degradation.

Authors:  Peng Kuang; Mingjia Tan; Weihua Zhou; Qiang Zhang; Yi Sun
Journal:  Sci Rep       Date:  2016-12-02       Impact factor: 4.379

7.  The Negative Cross-Talk between SAG/RBX2/ROC2 and APC/C E3 Ligases in Regulation of Cell Cycle Progression and Drug Resistance.

Authors:  Shizhen Zhang; Yanwen Shen; Hua Li; Chao Bi; Yilun Sun; Xiufang Xiong; Wenyi Wei; Yi Sun
Journal:  Cell Rep       Date:  2020-09-08       Impact factor: 9.423

Review 8.  The ubiquitin proteasome system - implications for cell cycle control and the targeted treatment of cancer.

Authors:  Florian Bassermann; Ruth Eichner; Michele Pagano
Journal:  Biochim Biophys Acta       Date:  2013-03-01

Review 9.  Regulation of cell cycle drivers by Cullin-RING ubiquitin ligases.

Authors:  Sang-Min Jang; Christophe E Redon; Bhushan L Thakur; Meriam K Bahta; Mirit I Aladjem
Journal:  Exp Mol Med       Date:  2020-10-02       Impact factor: 8.718
  9 in total

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