Domagoj Kifer1, Dario Bugada2, Judit Villar-Garcia3, Ivan Gudelj4, Cristina Menni5, Carole Sudre5, Frano Vučković4, Ivo Ugrina6, Luca F Lorini2, Margarita Posso3, Silvia Bettinelli2, Nicola Ughi7, Alessandro Maloberti7,8, Oscar Epis7, Cristina Giannattasio7,8, Claudio Rossetti7, Livije Kalogjera9, Jasminka Peršec10,11, Luke Ollivere12, Benjamin J Ollivere12, Huadong Yan13,14, Ting Cai13, Guruprasad P Aithal12, Claire J Steves5, Anu Kantele15, Mikael Kajova15, Olli Vapalahti16,17, Antti Sajantila18,19, Rafal Wojtowicz20, Waldemar Wierzba20, Zbigniew Krol20, Artur Zaczynski20, Katarina Zycinska20,21, Marek Postula22, Ivica Lukšić23, Rok Čivljak24,25,26, Alemka Markotić24, Johannes Brachmann27,28, Andreas Markl27, Christian Mahnkopf27, Benjamin Murray29, Sebastien Ourselin29, Ana M Valdes12, Juan P Horcajada3, Xavier Castells3, Julio Pascual3, Massimo Allegri30, Dragan Primorac27,28,31,32,33,34, Tim D Spector5, Clara Barrios3, Gordan Lauc1,4. 1. Faculty of Pharmacy and Biochemistry, University of Zagreb, Zagreb, Croatia. 2. Emergency and Intensive Care Department, Azienda Socio Sanitaria Territoriale Papa Giovanni XXIII Hospital, Bergamo, Italy. 3. Hospital del Mar-Institut Hospital del Mar d'Investigacions Mèdiques, Barcelona, Spain. 4. Genos Glycoscience Research Laboratory, Zagreb, Croatia. 5. Department of Twin Research and Genetic Epidemiology, King's College London, London, United Kingdom. 6. Faculty of Science, University of Split, Split, Croatia. 7. Azienda Socio Sanitaria Territoriale Grande Ospedale Metropolitano Niguarda, Milan, Italy. 8. School of Medicine and Surgery, Milano-Bicocca University, Milan, Italy. 9. Department of Otolaryngology-Head and Neck Surgery, Zagreb School of Medicine, University Hospital Centre "Sestre milosrdnice", Zagreb, Croatia. 10. Clinical Department of Anesthesiology, Reanimatology and Intensive Care Medicine, University Hospital Dubrava Zagreb, Zagreb, Croatia. 11. University of Zagreb School of Dental Medicine, Zagreb, Croatia. 12. National Institute for Health Research Nottingham Biomedical Research Centre, Nottingham University Hospitals National Health Service Trust and the University of Nottingham, Nottingham, United Kingdom. 13. Key Laboratory of Diagnosis and Treatment of Digestive System Tumors of Zhejiang Province, Department of Infectious Diseases, Hwamei Hospital, University of Chinese Academy of Sciences, Ningbo, China. 14. Ningbo Institute of Life and Health Industry, University of Chinese Academy of Sciences, Ningbo, China. 15. Inflammation Centre, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 16. Department of Virology, Helsingin ja Uudenmaan Sairaanhoitopiiri Diagnostic Center, Helsinki University Hospital, University of Helsinki, Helsinki, Finland. 17. Department of Veterinary Biosciences, University of Helsinki, Helsinki, Finland. 18. Department of Forensic Medicine, University of Helsinki, Helsinki, Finland. 19. Forensic Medicine Unit, Finnish Institute for Health and Welfare, Helsinki, Finland. 20. Central Clinical Hospital of Ministry of the Interior and Administration, Warsaw, Poland. 21. Medical University of Warsaw, Warsaw, Poland. 22. Department of Experimental and Clinical Pharmacology, Center for Preclinical Research and Technology CEPT, Medical University of Warsaw, Warsaw, Poland. 23. University of Zagreb School of Medicine, University Hospital Dubrava, Zagreb, Croatia. 24. University Hospital for Infectious Diseases "Fran Mihaljević", University of Zagreb School of Medicine, Zagreb, Croatia. 25. University Hospital for Infectious Diseases "Fran Mihaljević", Catholic University of Croatia, Zagreb, Croatia. 26. Medical School, University of Rijeka, Rijeka, Croatia. 27. REGIOMED Kliniken, Coburg, Germany. 28. University of Split School of Medicine, Split, Croatia. 29. School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom. 30. Pain Therapy Service Policlinico of Monza Hospital, Monza, Italy. 31. St. Catharine Hospital, Zagreb, Croatia. 32. Eberly College of Science, Penn State University, University Park, PA, United States. 33. University of Osijek School of Medicine, Osijek, Croatia. 34. Faculty of Dental Medicine and Health, University of Rijeka School of Medicine, University of Rijeka, Rijeka, Croatia.
Abstract
Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented. Methods: We examined the disease progression of COVID-19 in 6,914 patients admitted to hospitals in Europe and China. In addition, we evaluated progress of disease symptoms in 37,187 individuals reporting symptoms into the COVID Symptom Study application. Findings: Meta-analysis of the mortality risk in seven European hospitals estimated odds ratios per 1-day increase in the admission date to be 0.981 (0.973-0.988, p < 0.001) and per increase in ambient temperature of 1°C to be 0.854 (0.773-0.944, p = 0.007). Statistically significant decreases of comparable magnitude in median hospital stay, probability of transfer to the intensive care unit, and need for mechanical ventilation were also observed in most, but not all hospitals. The analysis of individually reported symptoms of 37,187 individuals in the UK also showed the decrease in symptom duration and disease severity with time. Interpretation: Severity of COVID-19 in Europe decreased significantly between March and May and the seasonality of COVID-19 is the most likely explanation.
Background: Most respiratory viruses show pronounced seasonality, but for SARS-CoV-2, this still needs to be documented. Methods: We examined the disease progression of COVID-19 in 6,914 patients admitted to hospitals in Europe and China. In addition, we evaluated progress of disease symptoms in 37,187 individuals reporting symptoms into the COVID Symptom Study application. Findings: Meta-analysis of the mortality risk in seven European hospitals estimated odds ratios per 1-day increase in the admission date to be 0.981 (0.973-0.988, p < 0.001) and per increase in ambient temperature of 1°C to be 0.854 (0.773-0.944, p = 0.007). Statistically significant decreases of comparable magnitude in median hospital stay, probability of transfer to the intensive care unit, and need for mechanical ventilation were also observed in most, but not all hospitals. The analysis of individually reported symptoms of 37,187 individuals in the UK also showed the decrease in symptom duration and disease severity with time. Interpretation: Severity of COVID-19 in Europe decreased significantly between March and May and the seasonality of COVID-19 is the most likely explanation.
Authors: Maximillian S Habibi; Ryan S Thwaites; Christopher Chiu; Peter J M Openshaw; Meiping Chang; Agnieszka Jozwik; Allan Paras; Freja Kirsebom; Augusto Varese; Amber Owen; Leah Cuthbertson; Phillip James; Tanushree Tunstall; David Nickle; Trevor T Hansel; Miriam F Moffatt; Cecilia Johansson Journal: Science Date: 2020-10-09 Impact factor: 63.714
Authors: Mahmood Yaseen Hachim; Ibrahim Y Hachim; Kashif Naeem; Haifa Hannawi; Issa Al Salmi; Suad Hannawi Journal: Front Public Health Date: 2021-03-19
Authors: Shi Zhao; Jingzhi Lou; Marc K C Chong; Lirong Cao; Hong Zheng; Zigui Chen; Renee W Y Chan; Benny C Y Zee; Paul K S Chan; Maggie H Wang Journal: Viruses Date: 2021-04-08 Impact factor: 5.048
Authors: Marc Modat; Sebastien Ourselin; Benjamin Murray; Eric Kerfoot; Liyuan Chen; Jie Deng; Mark S Graham; Carole H Sudre; Erika Molteni; Liane S Canas; Michela Antonelli; Kerstin Klaser; Alessia Visconti; Alexander Hammers; Andrew T Chan; Paul W Franks; Richard Davies; Jonathan Wolf; Tim D Spector; Claire J Steves Journal: Sci Data Date: 2021-11-22 Impact factor: 6.444
Authors: Ismaila Emahi; Mimmie Cnc Watts; Samuel Azibere; Joseph F Morrison; Kwabena An Sarpong Journal: Afr Health Sci Date: 2021-12 Impact factor: 0.927