Literature DB >> 33553146

Subchondral Bone Remodeling: A Therapeutic Target for Osteoarthritis.

Xiaobo Zhu1,2, Yau Tsz Chan1,3, Patrick S H Yung1,2, Rocky S Tuan1,3, Yangzi Jiang1,3.   

Abstract

There is emerging awareness that subchondral bone remodeling plays an important role in the development of osteoarthritis (OA). This review presents recent investigations on the cellular and molecular mechanism of subchondral bone remodeling, and summarizes the current interventions and potential therapeutic targets related to OA subchondral bone remodeling. The first part of this review covers key cells and molecular mediators involved in subchondral bone remodeling (osteoclasts, osteoblasts, osteocytes, bone extracellular matrix, vascularization, nerve innervation, and related signaling pathways). The second part of this review describes candidate treatments for OA subchondral bone remodeling, including the use of bone-acting reagents and the application of regenerative therapies. Currently available clinical OA therapies and known responses in subchondral bone remodeling are summarized as a basis for the investigation of potential therapeutic mediators.
Copyright © 2021 Zhu, Chan, Yung, Tuan and Jiang.

Entities:  

Keywords:  cellular and molecular targets; osteoarthritis; regenerative therapy; stem cells; subchondral bone; subchondral bone remodeling

Year:  2021        PMID： 33553146      PMCID： PMC7859330          DOI： 10.3389/fcell.2020.607764

Source DB:  PubMed          Journal:  Front Cell Dev Biol        ISSN： 2296-634X


  157 in total

Review 1.  Normal bone anatomy and physiology.

Authors:  Bart Clarke
Journal:  Clin J Am Soc Nephrol       Date:  2008-11       Impact factor: 8.237

Review 2.  Co-culture systems of osteoblasts and osteoclasts: Simulating in vitro bone remodeling in regenerative approaches.

Authors:  Giorgia Borciani; Giorgia Montalbano; Nicola Baldini; Giorgia Cerqueni; Chiara Vitale-Brovarone; Gabriela Ciapetti
Journal:  Acta Biomater       Date:  2020-04-03       Impact factor: 8.947

3.  Alendronate protects against articular cartilage erosion by inhibiting subchondral bone loss in ovariectomized rats.

Authors:  Songsong Zhu; Kan Chen; Yu Lan; Nan Zhang; Rulang Jiang; Jing Hu
Journal:  Bone       Date:  2013-01-02       Impact factor: 4.398

4.  Positive-Feedback Regulation of Subchondral H-Type Vessel Formation by Chondrocyte Promotes Osteoarthritis Development in Mice.

Authors:  Jiansen Lu; Haiyan Zhang; Daozhang Cai; Chun Zeng; Pinglin Lai; Yan Shao; Hang Fang; Delong Li; Jiayao Ouyang; Chang Zhao; Denghui Xie; Bin Huang; Jian Yang; Yu Jiang; Xiaochun Bai
Journal:  J Bone Miner Res       Date:  2018-03-24       Impact factor: 6.741

5.  Similarities and discrepancies in subchondral bone structure in two differently induced canine models of osteoarthritis.

Authors:  Femke Intema; Yvonne H Sniekers; Harrie Weinans; Marieke E Vianen; Sue A Yocum; Anne-Marie M Zuurmond; Jeroen DeGroot; Floris P Lafeber; Simon C Mastbergen
Journal:  J Bone Miner Res       Date:  2010-07       Impact factor: 6.741

6.  Age-Dependent Subchondral Bone Remodeling and Cartilage Repair in a Minipig Defect Model.

Authors:  Christian G Pfeifer; Matthew B Fisher; Vishal Saxena; Minwook Kim; Elizabeth A Henning; David A Steinberg; George R Dodge; Robert L Mauck
Journal:  Tissue Eng Part C Methods       Date:  2017-10-27       Impact factor: 3.056

7.  Spatial and temporal changes of subchondral bone proceed to microscopic articular cartilage degeneration in guinea pigs with spontaneous osteoarthritis.

Authors:  T Wang; C-Y Wen; C-H Yan; W-W Lu; K-Y Chiu
Journal:  Osteoarthritis Cartilage       Date:  2013-01-09       Impact factor: 6.576

8.  Protective effects of a cathepsin K inhibitor, SB-553484, in the canine partial medial meniscectomy model of osteoarthritis.

Authors:  J R Connor; C LePage; B A Swift; D Yamashita; A M Bendele; D Maul; S Kumar
Journal:  Osteoarthritis Cartilage       Date:  2009-04-05       Impact factor: 6.576

9.  Visualizing mineral binding and uptake of bisphosphonate by osteoclasts and non-resorbing cells.

Authors:  Fraser P Coxon; Keith Thompson; Anke J Roelofs; F Hal Ebetino; Michael J Rogers
Journal:  Bone       Date:  2008-01-26       Impact factor: 4.398

10.  Osteocyte dysfunction promotes osteoarthritis through MMP13-dependent suppression of subchondral bone homeostasis.

Authors:  Courtney M Mazur; Jonathon J Woo; Cristal S Yee; Aaron J Fields; Claire Acevedo; Karsyn N Bailey; Serra Kaya; Tristan W Fowler; Jeffrey C Lotz; Alexis Dang; Alfred C Kuo; Thomas P Vail; Tamara Alliston
Journal:  Bone Res       Date:  2019-11-05       Impact factor: 13.567
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  15 in total

1.  18F-NaF simultaneous PET/MRI in osteoarthritis: Initial observations with case illustration.

Authors:  Amarnath Jena; Nidhi Goyal; Raju Vaishya
Journal:  J Clin Orthop Trauma       Date:  2021-08-26

2.  Carnosine Alleviates Knee Osteoarthritis and Promotes Synoviocyte Protection via Activating the Nrf2/HO-1 Signaling Pathway: An In-Vivo and In-Vitro Study.

Authors:  Prabhakar Busa; Sing-Ong Lee; Niancih Huang; Yaswanth Kuthati; Chih-Shung Wong
Journal:  Antioxidants (Basel)       Date:  2022-06-20

3.  PTHrP promotes subchondral bone formation in TMJ-OA.

Authors:  Jun Zhang; Caixia Pi; Chen Cui; Yang Zhou; Bo Liu; Juan Liu; Xin Xu; Xuedong Zhou; Liwei Zheng
Journal:  Int J Oral Sci       Date:  2022-07-19       Impact factor: 24.897

Review 4.  Osteoarthritis Pathophysiology: Therapeutic Target Discovery may Require a Multifaceted Approach.

Authors:  Tonia L Vincent; Tamara Alliston; Mohit Kapoor; Richard F Loeser; Linda Troeberg; Christopher B Little
Journal:  Clin Geriatr Med       Date:  2022-05       Impact factor: 3.529

5.  Identification of Key Genes and Pathways in Osteoarthritis via Bioinformatic Tools: An Updated Analysis.

Authors:  Yijian Zhang; Tianfeng Zhu; Fan He; Angela Carley Chen; Huilin Yang; Xuesong Zhu
Journal:  Cartilage       Date:  2021-04-15       Impact factor: 3.117

6.  Differential proteomic analysis of tibial subchondral bone from male and female guinea pigs with spontaneous osteoarthritis.

Authors:  Ying Wang; Chengai Wu; Jianfeng Tao; Danhui Zhao; Xu Jiang; Wei Tian
Journal:  Exp Ther Med       Date:  2021-04-15       Impact factor: 2.447

7.  Vindoline Attenuates Osteoarthritis Progression Through Suppressing the NF-κB and ERK Pathways in Both Chondrocytes and Subchondral Osteoclasts.

Authors:  Meisong Zhu; Qiang Xu; Xinmin Yang; Haibo Zhan; Bin Zhang; Xuqiang Liu; Min Dai
Journal:  Front Pharmacol       Date:  2022-01-12       Impact factor: 5.810

8.  Dihydroartemisinin attenuates osteoclast formation and bone resorption via inhibiting the NF‑κB, MAPK and NFATc1 signaling pathways and alleviates osteoarthritis.

Authors:  Dong Ding; Jiangbo Yan; Gangning Feng; Yong Zhou; Long Ma; Qunhua Jin
Journal:  Int J Mol Med       Date:  2021-11-05       Impact factor: 4.101

9.  IκB-ζ signaling promotes chondrocyte inflammatory phenotype, senescence, and erosive joint pathology.

Authors:  Manoj Arra; Gaurav Swarnkar; Yael Alippe; Gabriel Mbalaviele; Yousef Abu-Amer
Journal:  Bone Res       Date:  2022-02-11       Impact factor: 13.567

Review 10.  The Development of Disease-Modifying Therapies for Osteoarthritis (DMOADs): The Evidence to Date.

Authors:  Win Min Oo; Christopher Little; Vicky Duong; David J Hunter
Journal:  Drug Des Devel Ther       Date:  2021-07-06       Impact factor: 4.162
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