Literature DB >> 33552483

Insights Into Metabolic Mechanisms and Their Application in the Treatment of NASH.

Phillip J White1, Manal F Abdelmalek2.   

Abstract

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© 2021 by the American Association for the Study of Liver Diseases.

Year:  2021        PMID： 33552483      PMCID： PMC7849290          DOI： 10.1002/cld.1062

Source DB:  PubMed          Journal:  Clin Liver Dis (Hoboken)        ISSN： 2046-2484


  11 in total

1.  Plasma BCAA Changes in Patients With NAFLD Are Sex Dependent.

Authors:  Guillaume Grzych; Luisa Vonghia; Marie-Adélaïde Bout; Jonas Weyler; An Verrijken; Eveline Dirinck; Marie Joncquel Chevalier Curt; Luc Van Gaal; Réjane Paumelle; Sven Francque; Anne Tailleux; Joel T Haas; Bart Staels
Journal:  J Clin Endocrinol Metab       Date:  2020-07-01       Impact factor: 5.958

2.  Increased de novo lipogenesis is a distinct characteristic of individuals with nonalcoholic fatty liver disease.

Authors:  Jennifer E Lambert; Maria A Ramos-Roman; Jeffrey D Browning; Elizabeth J Parks
Journal:  Gastroenterology       Date:  2013-12-04       Impact factor: 22.682

3.  Acetyl CoA Carboxylase Inhibition Reduces Hepatic Steatosis but Elevates Plasma Triglycerides in Mice and Humans: A Bedside to Bench Investigation.

Authors:  Chai-Wan Kim; Carol Addy; Jun Kusunoki; Norma N Anderson; Stanislaw Deja; Xiaorong Fu; Shawn C Burgess; Cai Li; Marcie Ruddy; Manu Chakravarthy; Steve Previs; Stuart Milstein; Kevin Fitzgerald; David E Kelley; Jay D Horton
Journal:  Cell Metab       Date:  2017-08-01       Impact factor: 27.287

4.  Acetyl-CoA carboxylase inhibition disrupts metabolic reprogramming during hepatic stellate cell activation.

Authors:  Jamie Bates; Archana Vijayakumar; Sarani Ghoshal; Bruno Marchand; Saili Yi; Dmytro Kornyeyev; Anna Zagorska; David Hollenback; Katie Walker; Kathy Liu; Swetha Pendem; David Newstrom; Robert Brockett; Igor Mikaelian; Saritha Kusam; Ricardo Ramirez; David Lopez; Li Li; Bryan C Fuchs; David G Breckenridge
Journal:  J Hepatol       Date:  2020-05-04       Impact factor: 25.083

Review 5.  Mechanisms of NAFLD development and therapeutic strategies.

Authors:  Scott L Friedman; Brent A Neuschwander-Tetri; Mary Rinella; Arun J Sanyal
Journal:  Nat Med       Date:  2018-07-02       Impact factor: 53.440

6.  Accumulation of PNPLA3 on lipid droplets is the basis of associated hepatic steatosis.

Authors:  Soumik BasuRay; Yang Wang; Eriks Smagris; Jonathan C Cohen; Helen H Hobbs
Journal:  Proc Natl Acad Sci U S A       Date:  2019-04-24       Impact factor: 11.205

7.  The BCKDH Kinase and Phosphatase Integrate BCAA and Lipid Metabolism via Regulation of ATP-Citrate Lyase.

Authors:  Phillip J White; Robert W McGarrah; Paul A Grimsrud; Shih-Chia Tso; Wen-Hsuan Yang; Jonathan M Haldeman; Thomas Grenier-Larouche; Jie An; Amanda L Lapworth; Inna Astapova; Sarah A Hannou; Tabitha George; Michelle Arlotto; Lyra B Olson; Michelle Lai; Guo-Fang Zhang; Olga Ilkayeva; Mark A Herman; R Max Wynn; David T Chuang; Christopher B Newgard
Journal:  Cell Metab       Date:  2018-05-17       Impact factor: 31.373

8.  Genetic variation in PNPLA3 confers susceptibility to nonalcoholic fatty liver disease.

Authors:  Stefano Romeo; Julia Kozlitina; Chao Xing; Alexander Pertsemlidis; David Cox; Len A Pennacchio; Eric Boerwinkle; Jonathan C Cohen; Helen H Hobbs
Journal:  Nat Genet       Date:  2008-09-25       Impact factor: 38.330

9.  Single phosphorylation sites in Acc1 and Acc2 regulate lipid homeostasis and the insulin-sensitizing effects of metformin.

Authors:  Morgan D Fullerton; Sandra Galic; Katarina Marcinko; Sarah Sikkema; Thomas Pulinilkunnil; Zhi-Ping Chen; Hayley M O'Neill; Rebecca J Ford; Rengasamy Palanivel; Matthew O'Brien; D Grahame Hardie; S Lance Macaulay; Jonathan D Schertzer; Jason R B Dyck; Bryce J van Denderen; Bruce E Kemp; Gregory R Steinberg
Journal:  Nat Med       Date:  2013-11-03       Impact factor: 53.440

10.  Dynamic interactions of ABHD5 with PNPLA3 regulate triacylglycerol metabolism in brown adipocytes.

Authors:  Alexander Yang; Emilio P Mottillo; Ljiljana Mladenovic-Lucas; Li Zhou; James G Granneman
Journal:  Nat Metab       Date:  2019-05-06
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  2 in total

1.  Novel Thienopyrimidines as Acetyl-CoA Carboxylase Inhibitors for Treating Liver Diseases.

Authors:  Ram W Sabnis
Journal:  ACS Med Chem Lett       Date:  2021-04-27       Impact factor: 4.345

2.  Altered branched-chain α-keto acid metabolism is a feature of NAFLD in individuals with severe obesity.

Authors:  Thomas Grenier-Larouche; Lydia Coulter Kwee; Yann Deleye; Paola Leon-Mimila; Jacquelyn M Walejko; Robert W McGarrah; Simon Marceau; Sylvain Trahan; Christine Racine; André C Carpentier; Aldons J Lusis; Olga Ilkayeva; Marie-Claude Vohl; Adriana Huertas-Vazquez; André Tchernof; Svati H Shah; Christopher B Newgard; Phillip J White
Journal:  JCI Insight       Date:  2022-08-08
  2 in total

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