C B Mainor1, C Isaacs2. 1. MedStar Georgetown University Hospital. 2. Georgetown University.
Abstract
PURPOSE OF REVIEW: We review the management for unaffected BRCA1/2 mutation carriers and the local management of early stage breast cancer. RECENT FINDINGS: For unaffected BRCA1/2 mutation carriers, surveillance includes annual magnetic resonance imaging (MRI) and mammogram (MG). Novel imaging modalities, including abbreviated protocol MRI, ultrafast/accelerated MRI, and contrast-enhanced digital mammography are being investigated. Risk reducing mastectomy (RRM) should be considered, and nipple-areolar sparing mastectomy (NSM) is now an option. Additionally, risk reducing salpingo-oophorectomy (RRSO) is strongly recommended as it reduces mortality.In BRCA1/2 mutation carriers with breast cancer, BCT is an appropriate treatment option but to reduce risk of second primary, mastectomy and contralateral risk-reducing mastectomy should be considered.
PURPOSE OF REVIEW: We review the management for unaffected BRCA1/2 mutation carriers and the local management of early stage breast cancer. RECENT FINDINGS: For unaffected BRCA1/2 mutation carriers, surveillance includes annual magnetic resonance imaging (MRI) and mammogram (MG). Novel imaging modalities, including abbreviated protocol MRI, ultrafast/accelerated MRI, and contrast-enhanced digital mammography are being investigated. Risk reducing mastectomy (RRM) should be considered, and nipple-areolar sparing mastectomy (NSM) is now an option. Additionally, risk reducing salpingo-oophorectomy (RRSO) is strongly recommended as it reduces mortality.In BRCA1/2 mutation carriers with breast cancer, BCT is an appropriate treatment option but to reduce risk of second primary, mastectomy and contralateral risk-reducing mastectomy should be considered.
Entities:
Keywords:
BRCA1; BRCA2; Breast Cancer; Breast conserving therapy
Authors: Kelly Metcalfe; Henry T Lynch; William D Foulkes; Nadine Tung; Charmaine Kim-Sing; Olufunmilayo I Olopade; Andrea Eisen; Barry Rosen; Carrie Snyder; Shelley Gershman; Ping Sun; Steven A Narod Journal: JAMA Oncol Date: 2015-06 Impact factor: 31.777
Authors: Wendie A Berg; Zheng Zhang; Daniel Lehrer; Roberta A Jong; Etta D Pisano; Richard G Barr; Marcela Böhm-Vélez; Mary C Mahoney; W Phil Evans; Linda H Larsen; Marilyn J Morton; Ellen B Mendelson; Dione M Farria; Jean B Cormack; Helga S Marques; Amanda Adams; Nolin M Yeh; Glenna Gabrielli Journal: JAMA Date: 2012-04-04 Impact factor: 56.272
Authors: Sunil R Lakhani; Marc J Van De Vijver; Jocelyne Jacquemier; Thomas J Anderson; Peter P Osin; Lesley McGuffog; Douglas F Easton Journal: J Clin Oncol Date: 2002-05-01 Impact factor: 44.544
Authors: Alexandra J van den Broek; Marjanka K Schmidt; Laura J van 't Veer; Hester S A Oldenburg; Emiel J Rutgers; Nicola S Russell; Vincent T H B M Smit; Adri C Voogd; Linetta B Koppert; Sabine Siesling; Jan J Jobsen; Pieter J Westenend; Flora E van Leeuwen; Rob A E M Tollenaar Journal: Ann Surg Date: 2019-08 Impact factor: 12.969
Authors: Carlos A Garcia-Etienne; Monica Barile; Oreste D Gentilini; Edoardo Botteri; Nicole Rotmensz; Andrea Sagona; Gabriel Farante; Viviana Galimberti; Alberto Luini; Paolo Veronesi; Bernardo Bonanni Journal: Ann Surg Oncol Date: 2009-12 Impact factor: 5.344
Authors: Martin P Nilsson; Linda Hartman; Ulf Kristoffersson; Oskar T Johannsson; Ake Borg; Karin Henriksson; Elsa Lanke; Håkan Olsson; Niklas Loman Journal: Breast Cancer Res Treat Date: 2014-09-04 Impact factor: 4.872
Authors: Jan Drooger; Delal Akdeniz; Jean-Philippe Pignol; Linetta B Koppert; Danielle McCool; Caroline M Seynaeve; Maartje J Hooning; Agnes Jager Journal: Breast Cancer Res Treat Date: 2015-11 Impact factor: 4.872
Authors: Susan Shanley; Kate McReynolds; Audrey Ardern-Jones; Roger Ahern; Indrajit Fernando; John Yarnold; Gareth Evans; Diana Eccles; Shirley Hodgson; Sue Ashley; Linda Ashcroft; Andrew Tutt; Elizabeth Bancroft; Susan Short; Gerald Gui; Lester Barr; Andrew Baildam; Anthony Howell; Gavin Royle; Lori Pierce; Douglas Easton; Rosalind Eeles Journal: Clin Cancer Res Date: 2006-12-01 Impact factor: 12.531
Authors: Kelly Metcalfe; Shelley Gershman; Parviz Ghadirian; Henry T Lynch; Carrie Snyder; Nadine Tung; Charmaine Kim-Sing; Andrea Eisen; William D Foulkes; Barry Rosen; Ping Sun; Steven A Narod Journal: BMJ Date: 2014-02-11