Eman Mostafa Sanad1,2,3,4, Asmaa Adel El-Fallah1,2,3,4, Ahmed Raad Al-Doori1,2,3,4, Rehab Mohammed Salem1,2,3,4. 1. Dr. Sanad is Professor of Dermatology and Andrology, Faculty of Medicine, at Benha University in Banha, Egypt. 2. Dr. El-fallah is Lecturer of Chemical and Clinical Pathology, Faculty of Medicine, at Benha University in Banha, Egypt. 3. Dr. Al-doori is a dermatology resident at Baghdad University in Baghdad, Iraq. 4. Dr. Salem is Assistant Professor of Dermatology and Andrology, Faculty of Medicine, at Benha University in Banha, Egypt.
Abstract
BACKGROUND: The relation between zinc and the cytokines involved in vitiligo pathogenesis has not been studied well. OBJECTIVE: We aimed to investigate the serum levels of zinc in patients with vitiligo and to assess their relation to serum interleukins (IL)-4, IL-6, and IL-17. PATIENTS AND METHODS: The study included 50 patients with active vitiligo and 100 age-, sex-, and BMI-matched healthy volunteers as a control group. Serum zinc levels, IL-4, IL-6, IL-17 were evaluated in all participants. RESULTS: The mean serum levels of zinc was significantly reduced in patients with vitiligo, while the serum levels of IL-17, IL-4, and IL-6 were significantly elevated in the vitiligo group when compared with the controls (P<0.001). The serum zinc levels showed significant negative correlation with serum IL-6, IL-4. and IL-17 levels (P< 0.05). There was a significant positive correlation between the serum levels of the three studied interleukins (P< 0.001). CONCLUSION: Zinc supplementation could potentially be used as a beneficial treatment for vitiligo, but the required dosage needs to be studied further.
BACKGROUND: The relation between zinc and the cytokines involved in vitiligo pathogenesis has not been studied well. OBJECTIVE: We aimed to investigate the serum levels of zinc in patients with vitiligo and to assess their relation to serum interleukins (IL)-4, IL-6, and IL-17. PATIENTS AND METHODS: The study included 50 patients with active vitiligo and 100 age-, sex-, and BMI-matched healthy volunteers as a control group. Serum zinc levels, IL-4, IL-6, IL-17 were evaluated in all participants. RESULTS: The mean serum levels of zinc was significantly reduced in patients with vitiligo, while the serum levels of IL-17, IL-4, and IL-6 were significantly elevated in the vitiligo group when compared with the controls (P<0.001). The serum zinc levels showed significant negative correlation with serum IL-6, IL-4. and IL-17 levels (P< 0.05). There was a significant positive correlation between the serum levels of the three studied interleukins (P< 0.001). CONCLUSION: Zinc supplementation could potentially be used as a beneficial treatment for vitiligo, but the required dosage needs to be studied further.
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