Charlotte Lens1,2,3,4, Jelle Demeestere1,2,3, Kris Vanhaecht4,5, Robin Lemmens1,2,3. 1. Department of Neurology, University Hospitals Leuven, Leuven, Belgium. 2. Department of Neurosciences, Experimental Neurology, KU Leuven - University of Leuven, Leuven, Belgium. 3. Center for Brain & Disease Research, Laboratory of Neurobiology, VIB, Leuven, Belgium. 4. Leuven Institute for Healthcare Policy - Department of Public Health, KU Leuven - University of Leuven, Leuven, Belgium. 5. Department of Quality Management, University Hospitals Leuven, Leuven, Belgium.
Abstract
Introduction: The modified Rankin Scale (mRS) after 90 days documents outcome in stroke patients, but focusses only on activities of daily living. Here we studied stroke outcome beyond these activities by the Dutch-Flemish version of the Patient Reported Outcomes Measurement Information System (PROMIS) questionnaire. Patients and Methods: We documented the mRS at day 90 in stroke patients who filled out a questionnaire on pain intensity and seven PROMIS domains: physical function, ability to participate in social roles, anxiety, fatigue, depression, sleep disturbance, pain interference. In a subgroup of patients this questionnaire was reduced to one overall question per PROMIS domain. We correlated these findings with the mRS. Results: We received 102 questionnaires and identified physical function as the most affected PROMIS domain. The strongest correlation with mRS was found for the health domains of physical function (ρs = 0.70, p < 0.001) and ability to participate in social roles (ρs = 0.61, p < 0.001). The other domains with substantial proportions of patients with worse scores compared to the general population (19-44%) correlated weakly with the mRS. We identified a strong correlation between the single question per health domain and the overall score per PROMIS domain. Discussion and Conclusion: PROMIS better reflects the overall health status of stroke patients beyond functional outcome as measured by the mRS. Simplification of the questionnaire with a single question per PROMIS domain could potentially replace the full questionnaire, but needs further validation.
Introduction: The modified Rankin Scale (mRS) after 90 days documents outcome in strokepatients, but focusses only on activities of daily living. Here we studied stroke outcome beyond these activities by the Dutch-Flemish version of the Patient Reported Outcomes Measurement Information System (PROMIS) questionnaire. Patients and Methods: We documented the mRS at day 90 in strokepatients who filled out a questionnaire on pain intensity and seven PROMIS domains: physical function, ability to participate in social roles, anxiety, fatigue, depression, sleep disturbance, pain interference. In a subgroup of patients this questionnaire was reduced to one overall question per PROMIS domain. We correlated these findings with the mRS. Results: We received 102 questionnaires and identified physical function as the most affected PROMIS domain. The strongest correlation with mRS was found for the health domains of physical function (ρs = 0.70, p < 0.001) and ability to participate in social roles (ρs = 0.61, p < 0.001). The other domains with substantial proportions of patients with worse scores compared to the general population (19-44%) correlated weakly with the mRS. We identified a strong correlation between the single question per health domain and the overall score per PROMIS domain. Discussion and Conclusion: PROMIS better reflects the overall health status of strokepatients beyond functional outcome as measured by the mRS. Simplification of the questionnaire with a single question per PROMIS domain could potentially replace the full questionnaire, but needs further validation.
Authors: Tharshanah Thayabaranathan; Nadine E Andrew; Monique F Kilkenny; Rene Stolwyk; Amanda G Thrift; Rohan Grimley; Trisha Johnston; Vijaya Sundararajan; Natasha A Lannin; Dominique A Cadilhac Journal: Qual Life Res Date: 2018-08-04 Impact factor: 4.147
Authors: Henk J Arwert; Daniella M Oosterveer; Jan W Schoones; Caroline B Terwee; Thea P M Vliet Vlieland Journal: Arch Rehabil Res Clin Transl Date: 2022-03-25