Hefei Tang1,2,3,4, Jiayao Sun5, Yu Wang1,2,3,4, Xu Jie1,2,3,4, Yan Ma6, Anxin Wang1,2,3,4, Yijun Zhang1,2,3,4, Xingao Wang1,2,3,4, Yongjun Wang1,2,3,4. 1. Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China. 2. China National Clinical Research Center for Neurological Diseases, Beijing, China. 3. Center of Stroke, Beijing Institute for Brain Disorders, Beijing, China. 4. Beijing Key Laboratory of Translational Medicine for Cerebrovascular Disease, Beijing, China. 5. Department of Neurology, Zhangjiakou First Hospital, Hebei, China. 6. Division of Cardiology, Department of Internal Medicine, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Abstract
Background and Purpose: QT dispersion (QTd) abnormalities are widely documented in stroke patients. This study aims to investigate the association between QTd and clinical outcomes in IS patients. Methods: IS patients registered in the Blood Pressure and Clinical Outcome in transient ischemic attack (TIA) or IS (BOSS) registry between 2012 and 2014 within 24 h of onset were analyzed. In this prospective observational study, we identified 1,522 IS cases with adequate electrocardiographic evaluations to assess QTd after the index stroke. Patients were classified into four groups based on the quartile of QTd, with the lowest group as the reference. The primary stroke outcome was defined as a modified Rankin Scale score ≥3 at 1-year. Multiple logistic regressions were utilized to investigate the association between QTd and outcome events. Results: The mean QTd across all cases was 57 ms (40-83). Functional dependency or death was documented in 214 (14.98%) cases at 1 year. After adjusting for confounders, the prevalence of death and major disability (mRS ≥ 3) showed significant differences according to the quartile of QTd, with the risk of death and major disability (mRS ≥ 3) at 1 year being significantly higher for patients in Q4 than for those in Q1 (adjusted OR = 1.626, 95% CI:1.033-2.560). However, there were no significant correlation between QTd and the event outcomes at 1 year. Conclusions: QTd was associated with poor functional outcomes at 1 year. QTd is a useful surrogate marker for adverse functional prognosis, which might help to stratify risk in patients with acute IS.
Background and Purpose: QT dispersion (QTd) abnormalities are widely documented in strokepatients. This study aims to investigate the association between QTd and clinical outcomes in IS patients. Methods: IS patients registered in the Blood Pressure and Clinical Outcome in transient ischemic attack (TIA) or IS (BOSS) registry between 2012 and 2014 within 24 h of onset were analyzed. In this prospective observational study, we identified 1,522 IS cases with adequate electrocardiographic evaluations to assess QTd after the index stroke. Patients were classified into four groups based on the quartile of QTd, with the lowest group as the reference. The primary stroke outcome was defined as a modified Rankin Scale score ≥3 at 1-year. Multiple logistic regressions were utilized to investigate the association between QTd and outcome events. Results: The mean QTd across all cases was 57 ms (40-83). Functional dependency or death was documented in 214 (14.98%) cases at 1 year. After adjusting for confounders, the prevalence of death and major disability (mRS ≥ 3) showed significant differences according to the quartile of QTd, with the risk of death and major disability (mRS ≥ 3) at 1 year being significantly higher for patients in Q4 than for those in Q1 (adjusted OR = 1.626, 95% CI:1.033-2.560). However, there were no significant correlation between QTd and the event outcomes at 1 year. Conclusions: QTd was associated with poor functional outcomes at 1 year. QTd is a useful surrogate marker for adverse functional prognosis, which might help to stratify risk in patients with acute IS.
Authors: Jacob Abraham; James O Mudd; Navin K Kapur; Navin Kapur; Kelly Klein; Hunter C Champion; Ilan S Wittstein Journal: J Am Coll Cardiol Date: 2009-04-14 Impact factor: 24.094
Authors: Latha G Stead; Rachel M Gilmore; M Fernanda Bellolio; Lekshmi Vaidyanathan; Amy L Weaver; Wyatt W Decker; Robert D Brown Journal: J Stroke Cerebrovasc Dis Date: 2009 Nov-Dec Impact factor: 2.136
Authors: Bushra S Rana; Margaret M Band; Simon Ogston; Andrew D Morris; Stuart D Pringle; Allan D Struthers Journal: Am J Cardiol Date: 2002-09-01 Impact factor: 2.778